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4
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Indiscernible benefit of high-resolution HLA typing in improving long-term clinical outcome of unrelated umbilical cord blood transplant
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A retrospective analysis demonstrating that high-resolution typing does not improve outcomes in unrelated UCBT
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Liao C, Wu JY, Xu ZP, et al. Indiscernible benefit of high-resolution HLA typing in improving long-term clinical outcome of unrelated umbilical cord blood transplant. Bone Marrow Transplant 2007; 40:201-208. A retrospective analysis demonstrating that high-resolution typing does not improve outcomes in unrelated UCBT.
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Liao, C.1
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Takahashi S, Ooi J, Tomonari A, et al. Comparative single-institute analysis of cord blood transplantation from unrelated donors with bone marrow or peripheral blood stem-cell transplants from related donors in adult patients with hematologic malignancies after myeloablative conditioning regimen. Blood 2007; 109:1322-1330. A single-institution study demonstrating comparable outcomes in patients with hematologic malignancies (primarily AML) receiving cord blood transplants from URDs versus those receiving transplants with bone marrow or peripheral blood from related donors.
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Takahashi S, Ooi J, Tomonari A, et al. Comparative single-institute analysis of cord blood transplantation from unrelated donors with bone marrow or peripheral blood stem-cell transplants from related donors in adult patients with hematologic malignancies after myeloablative conditioning regimen. Blood 2007; 109:1322-1330. A single-institution study demonstrating comparable outcomes in patients with hematologic malignancies (primarily AML) receiving cord blood transplants from URDs versus those receiving transplants with bone marrow or peripheral blood from related donors.
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8
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Unrelated cord blood transplantation for adult patients with de novo acute myeloid leukemia
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Ooi J, Iseki T, Takahashi S, et al. Unrelated cord blood transplantation for adult patients with de novo acute myeloid leukemia. Blood 2004; 103:489-491.
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Ooi, J.1
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1 and demonstrated comparable outcomes in the two groups; thus, demonstrating the safety and efficacy of this approach for patients without a MRD.
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1 and demonstrated comparable outcomes in the two groups; thus, demonstrating the safety and efficacy of this approach for patients without a MRD.
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10
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Hematopoietic cell transplantation (HCT)-specific comorbidity index: A new tool for risk assessment before allogeneic HCT
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Sorror ML, Maris MB, Storb R, et al. Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT. Blood 2005; 106:2912-2919.
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Barker JN, Weisdorf DJ, Wagner JE. Creation of a double chimera after the transplantation of umbilical-cord blood from two partially matched unrelated donors. N Engl J Med 2001; 344:1870-1871.
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Wagner, J.E.3
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- NK cells in the peripheral blood of cord blood transplant recipients: A unique subset of NK cells possibly associated with graft-versus-leukemia effect
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- NK cells in the peripheral blood of cord blood transplant recipients with AML, thereby suggesting that NK cells may play an important role in the GVL effect after UCBT
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- NK cells in the peripheral blood of cord blood transplant recipients with AML, thereby suggesting that NK cells may play an important role in the GVL effect after UCBT.
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Eur J Haematol
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Lu, X.1
Kondo, Y.2
Takmatsu, H.3
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13
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A large retrospective study demonstrating improved outcomes to GVHD treatment in UCB recipients versus URD recipients
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Arora M, Nagaraj S, Wagner JE, et al. Chronic graft-versus-host disease (cGVHD) following unrelated donor hematopoietic stem cell transplantation: higher response rates in recipients of unrelated donor (URD) umbilical cord blood (UCB). Biol Blood and Marrow Transplant 2007; 13:1145-1152. A large retrospective study demonstrating improved outcomes to GVHD treatment in UCB recipients versus URD recipients.
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Arora, M.1
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14
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Komanduri KV, St John LS, de Lima M, et al. Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T cell skewing. Blood 2007; 110:4543-4551. The first robust prospective study evaluating changes in the immune system, including impaired thymopoiesis and late memory T-cell skewing, after UCBT.
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Komanduri KV, St John LS, de Lima M, et al. Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T cell skewing. Blood 2007; 110:4543-4551. The first robust prospective study evaluating changes in the immune system, including impaired thymopoiesis and late memory T-cell skewing, after UCBT.
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15
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Ex vivo expansion of umbilical cord blood stem cells for transplantation: Growing knowledge from the hematopoietic niche
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Hofmeister CC, Zhang J, Knight KL, et al. Ex vivo expansion of umbilical cord blood stem cells for transplantation: growing knowledge from the hematopoietic niche. Bone Marrow Transplant 2007; 39:11-23.
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Hofmeister, C.C.1
Zhang, J.2
Knight, K.L.3
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Optimization of expansion of cord blood T cells with anti-CD3/anti-CD28 coated beads
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Rieber AG, Parmar S, Robinson SN, et al. Optimization of expansion of cord blood T cells with anti-CD3/anti-CD28 coated beads, Biol Blood Marrow Transplant 2006; 12 (2 Suppl 1):81-82.
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Biol Blood Marrow Transplant
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Rieber, A.G.1
Parmar, S.2
Robinson, S.N.3
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In vitro priming and expansion of cytomegalovirus-specific Th1 and Tc1 T cells from naive cord blood lymphocytes
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Park KD, Marti L, Kurtzberg J, et al. In vitro priming and expansion of cytomegalovirus-specific Th1 and Tc1 T cells from naive cord blood lymphocytes. Blood 2006; 108:1770-1773.
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Park, K.D.1
Marti, L.2
Kurtzberg, J.3
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Factors associated with outcomes of unrelated cord blood transplant: Guidelines for donor choice
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Gluckman E, Rocha V, Arcese W, et al. Factors associated with outcomes of unrelated cord blood transplant: guidelines for donor choice. Exp Hematol 2004; 32:397-407.
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Gluckman, E.1
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+ cell doses
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A large study demonstrating the importance of cell dose in UCBT on clinical outcomes
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+ cell doses. Biol of Blood and Marrow Transplant 2007; 13:822-830. A large study demonstrating the importance of cell dose in UCBT on clinical outcomes.
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Biol of Blood and Marrow Transplant
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Terakura, S.1
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Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy
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Barker JN, Weisdorf DJ, DeFor TE, et al. Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood 2005; 105:1343-1347.
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Barker, J.N.1
Weisdorf, D.J.2
DeFor, T.E.3
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22
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Risk of relapse (REL) after umbilical cord blood transplantation (UCBT) in patients with acute leukemia: Marked reduction in recipients of two units [abstract]
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Verneris MR, Brunstein C, DeFor TE, et al. Risk of relapse (REL) after umbilical cord blood transplantation (UCBT) in patients with acute leukemia: marked reduction in recipients of two units [abstract]. Blood 2005; 106:93a.
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Ballen KK, Spitzer TR, Yeap B, et al. Excellent disease-free survival after double cord blood transplantation using a reduced intensity chemotherapy only conditioning regimen in a diverse adult population [abstract #2048]. ASH Annu Meeting Abstr 2005; 106:.
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Multiple unit HLA-unmatched sexmismatched umbilical cord blood transplantation for advanced hematological malignancy
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Rosenzwajg M, Giarratana MC, Gluckman JC, et al. Incidence of ex vivo expansion on the capacity of cord blood graft to generate immune cells: rational for co-infusion of expanded and non expanded fractions? [Abstract #407], Blood 2004; 104:.
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Rosenzwajg M, Giarratana MC, Gluckman JC, et al. Incidence of ex vivo expansion on the capacity of cord blood graft to generate immune cells: rational for co-infusion of expanded and non expanded fractions? [Abstract #407], Blood 2004; 104:.
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Superior ex vivo cord blood expansion following co-culture with bone marrow-derived mesenchymal stem cells
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Robinson SN, Ng J, Niu T, et al. Superior ex vivo cord blood expansion following co-culture with bone marrow-derived mesenchymal stem cells. Bone Marrow Transplant 2006; 37:359-366.
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