The C-terminal domain of Plasmodium falciparum merozoite surface protein 3 self-assembles into α-helical coiled coil tetramer

Molecular and Biochemical Parasitology

Volumn 165, Issue 2, 2009, Pages 153-161

  Gondeau, Claire ^a   Corradin, Giampietro ^b   Heitz, Frédéric ^a   Le Peuch, Christian ^a   Balbo, Andrea ^c   Schuck, Peter ^c   Kajava, Andrey V ^a  

^a Centre National de la Recherche Scientifique   (France)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

Author keywords

Helical coiled coil; Oligomerization; Plasmodium falciparum; Protein structure

Indexed keywords

ANTIBODY; MEMBRANE PROTEIN; MEROZOITE SURFACE PROTEIN 3; PARASITE ANTIGEN; TETRAMER; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; BIOINFORMATICS; BIOPHYSICS; CARBOXY TERMINAL SEQUENCE; HOST; MALARIA; NONHUMAN; OLIGOMERIZATION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN FUNCTION; PROTEIN STRUCTURE;

ANIMALS; ANTIGENS, PROTOZOAN; MODELS, MOLECULAR; PLASMODIUM FALCIPARUM; POLYMERS; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTOZOAN PROTEINS; ULTRACENTRIFUGATION;

PLASMODIUM FALCIPARUM;

EID: 62249099133     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2009.01.015     Document Type: Article

References (43)

1. Richie T.L., and Saul A. Progress and challenges for malaria vaccines. Nature 415 (2002) 694-701
2. Meraldi V., Nebie I., Tiono A.B., et al. Natural antibody response to Plasmodium falciparum Exp-1, MSP-3 and GLURP long synthetic peptides and association with protection. Parasite Immunol 26 (2004) 265-272
3. Gaur D., Mayer D.C., and Miller L.H. Parasite ligand-host receptor interactions during invasion of erythrocytes by Plasmodium merozoites. Int J Parasitol 34 (2004) 1413-1429
4. Gerold P., Schofield L., Blackman M.J., Holder A.A., and Schwarz R.T. Structural analysis of the glycosyl-phosphatidylinositol membrane anchor of the merozoite surface proteins-1 and -2 of Plasmodium falciparum. Mol Biochem Parasitol 75 (1996) 131-143
5. Marshall V.M., Silva A., Foley M., et al. A second merozoite surface protein (MSP-4) of Plasmodium falciparum that contains an epidermal growth factor-like domain. Infect Immun 65 (1997) 4460-4467
6. Black C.G., Wang L., Wu T., and Coppel R.L. Apical location of a novel EGF-like domain-containing protein of Plasmodium falciparum. Mol Biochem Parasitol 127 (2003) 59-68
7. Stahl H.D., Bianco A.E., Crewther P.E., et al. Sorting large numbers of clones expressing Plasmodium falciparum antigens in Escherichia coli by differential antibody screening. Mol Biol Med 3 (1986) 351-368
8. Pachebat J.A., Ling I.T., Grainger M., et al. The 22 kDa component of the protein complex on the surface of Plasmodium falciparum merozoites is derived from a larger precursor, merozoite surface protein 7. Mol Biochem Parasitol 117 (2001) 83-89
9. Trucco C., Fernandez-Reyes D., Howell S., et al. The merozoite surface protein 6 gene codes for a 36 kDa protein associated with the Plasmodium falciparum merozoite surface protein-1 complex. Mol Biochem Parasitol 112 (2001) 91-101
10. Weber J.L., Lyon J.A., Wolff R.H., Hall T., Lowell G.H., and Chulay J.D. Primary structure of a Plasmodium falciparum malaria antigen located at the merozoite surface and within the parasitophorous vacuole. J Biol Chem 263 (1988) 11421-11425
11. McColl D.J., and Anders R.F. Conservation of structural motifs and antigenic diversity in the Plasmodium falciparum merozoite surface protein-3 (MSP-3). Mol Biochem Parasitol 90 (1997) 21-31
12. Singh S., Soe S., Mejia J.P., et al. Identification of a conserved region of Plasmodium falciparum MSP3 targeted by biologically active antibodies to improve vaccine design. J Infect Dis 190 (2004) 1010-1018
13. Oeuvray C., Bouharoun-Tayoun H., Gras-Masse H., et al. Merozoite surface protein-3: a malaria protein inducing antibodies that promote Plasmodium falciparum killing by cooperation with blood monocytes. Blood 84 (1994) 1594-1602
14. McColl D.J., Silva A., Foley M., et al. Molecular variation in a novel polymorphic antigen associated with Plasmodium falciparum merozoites. Mol Biochem Parasitol 68 (1994) 53-67
15. Pearce J.A., Hodder A.N., and Anders R.F. The alanine-rich heptad repeats are intact in the processed form of Plasmodium falciparum MSP3. Exp Parasitol 108 (2004) 186-189
16. Burgess B.R., Schuck P., and Garboczi D.N. Dissection of merozoite surface protein 3, a representative of a family of Plasmodium falciparum surface proteins, reveals an oligomeric and highly elongated molecule. J Biol Chem 280 (2005) 37236-37245
17. Altschul S.F., Madden T.L., Schaffer A.A., et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25 (1997) 3389-3402
18. Bucher P., Karplus K., Moeri N., and Hofmann K. A flexible motif search technique based on generalized profiles. Comput Chem 20 (1996) 3-23
19. Hofmann K., and Bucher P. The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors. Trends Biochem Sci 20 (1995) 347-349
20. Schuck P. Sedimentation equilibrium analysis of interference optical data by systematic noise decomposition. Anal Biochem 272 (1999) 199-208
21. Schuck P. Size distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and Lamm equation modeling. Biophys. J. 78 (2000) 1606-1619
22. Vistica J., Dam J., Balbo A., et al. Sedimentation equilibrium analysis of protein interactions with global implicit mass conservation constraints and systematic noise decomposition. Anal. Biochem. 326 (2004) 234-256
23. Schuck P. On the analysis of protein self-association by sedimentation velocity analytical ultracentrifugation. Anal. Biochem. 320 (2003) 104-124
24. Laue T.M., Shah B.D., Ridgeway T.M., and Pelletier S.L. Computer-aided interpretation of analytical sedimentation data for proteins. Anal Ultracentrif Biochem Polym Sci (1992) 90-125
25. Garcia de la Torre J., Huertas M.L., and Carrasco B. Calculation of hydrodynamic properties of globular proteins from their atomic-level structure. Biophys J 78 (2000) 719-730
26. Pearce J.A., Mills K., Triglia T., Cowman A.F., and Anders R.F. Characterisation of two novel proteins from the asexual stage of Plasmodium falciparum, H101 and H103. Mol Biochem Parasitol 139 (2005) 141-151
27. Villard V., Agak G.W., Frank G., et al. Rapid identification of malaria vaccine candidates based on alpha-helical coiled coil protein motif. PLoS ONE 2 (2007) e645
28. Johnson W.C. Analyzing protein circular dichroism spectra for accurate secondary structures. Proteins 35 (1999) 307-312
29. Lau S.Y., Taneja A.K., and Hodges R.S. Synthesis of a model protein of defined secondary and quaternary structure. Effect of chain length on the stabilization and formation of two-stranded alpha-helical coiled-coils. J Biol Chem 259 (1984) 13253-13261
30. Lu S.M., and Hodges R.S. Defining the minimum size of a hydrophobic cluster in two-stranded alpha-helical coiled-coils: effects on protein stability. Protein Sci 13 (2004) 714-726
31. Privalov P.L., and Potekhin S.A. Scanning microcalorimetry in studying temperature-induced changes in proteins. Methods Enzymol 131 (1986) 4-51
32. Yikilmaz E., Rouault T.A., and Schuck P. Self-association and ligand-induced conformational changes of iron regulatory proteins 1 and 2. Biochemistry 44 (2005) 8470-8478
33. Brown P.H., Balbo A., and Schuck P. Characterizing protein-protein interactions by sedimentation velocity analytical ultracentrifugation. Curr Protoc Immunol (2008) [Chapter 18:Unit 18 15]
34. Harbury P.B., Zhang T., Kim P.S., and Alber T. A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutants. Science 262 (1993) 1401-1407
35. Deng Y., Zheng Q., Liu J., Cheng C.S., Kallenbach N.R., and Lu M. Self-assembly of coiled-coil tetramers in the 1.40 Å structure of a leucine-zipper mutant. Protein Sci 16 (2007) 323-328
36. Dayring H.E., Tramonato A., Sprang S.R., and Fletterick R.J. Interactive program for visualization and modelling of proteins, nucleic acids and small molecules. J. Mol. Graphics 4 (1986) 82-87
37. Akey D.L., Malashkevich V.N., and Kim P.S. Buried polar residues in coiled-coil interfaces. Biochemistry 40 (2001) 6352-6360
38. Giraldo L.E., Grab D.J., and Wiser M.F. Molecular characterization of a Plasmodium chabaudi erythrocyte membrane-associated protein with glutamate-rich tandem repeats. J Eukaryot Microbiol 45 (1998) 528-534
39. Terskikh A.V., Le Doussal J.M., Crameri R., Fisch I., Mach J.P., and Kajava A.V. "Peptabody": a new type of high avidity binding protein. Proc Natl Acad Sci USA 94 (1997) 1663-1668
40. Mills K.E., Pearce J.A., Crabb B.S., and Cowman A.F. Truncation of merozoite surface protein 3 disrupts its trafficking and that of acidic-basic repeat protein to the surface of Plasmodium falciparum merozoites. Mol Microbiol 43 (2002) 1401-1411
41. Singh S., Soe S., Roussilhon C., Corradin G., and Druilhe P. Plasmodium falciparum merozoite surface protein 6 displays multiple targets for naturally occurring antibodies that mediate monocyte-dependent parasite killing. Infect Immun 73 (2005) 1235-1238
42. Wiser M.F., Sartorelli A.C., and Patton C.L. Association of Plasmodium berghei proteins with the host erythrocyte membrane: binding to inside-out vesicles. Mol Biochem Parasitol 38 (1990) 121-134
43. Rodriguez L.E., Curtidor H., Ocampo M., et al. Identifying Plasmodium falciparum merozoite surface antigen 3 (MSP3) protein peptides that bind specifically to erythrocytes and inhibit merozoite invasion. Protein Sci 14 (2005) 1778-1786