Optimizing melphalan pharmacokinetics in regional melanoma therapy: Does correcting for ideal body weight alter regional response or toxicity?

Annals of Surgical Oncology

Volumn 16, Issue 4, 2009, Pages 953-961

  McMahon, N ^a   Cheng, T Y ^b   Beasley, G M ^a   Spasojevic, I ^a   Petros, W ^c   Augustine, C K ^a,d   Zipfel, P ^a,d   Padussis, J C ^a,d   Sanders, G ^a   Tyler, Douglas S ^a,d  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c WEST VIRGINIA UNIVERSITY   (United States)

^d DURHAM VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MELPHALAN;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; BODY WEIGHT; CLINICAL ARTICLE; COMPARTMENT SYNDROME; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; FEMALE; HUMAN; MALE; MELANOMA; SIDE EFFECT;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS, ALKYLATING; BODY WEIGHT; CHEMOTHERAPY, CANCER, REGIONAL PERFUSION; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTREMITIES; FEMALE; HUMANS; MALE; MELANOMA; MELPHALAN; MIDDLE AGED; SKIN NEOPLASMS;

EID: 62149140209     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-008-0288-1     Document Type: Article

References (27)

1. JF Thompson PC Kam RC Waugh CR Harman 1998 Isolated limb infusion with cytotoxic agents: a simple alternative to isolated limb perfusion Semin Surg Oncol 14 238 47
2. JF Thompson RC Waugh RPM Saw PCA Kam 1994 Isolated limb infusion with melphalan for recurrent limb melanoma: a simple alternative to isolated limb perfusion Reg Cancer Treat 7 188 92
3. GM Beasley RP Petersen J Yoo N McMahon T Aloia W Petros 2008 Isolated limb infusion for in-transit malignant melanoma of the extremity: a well tolerated but less effective alternative to hyperthermic isolated limb perfusion Ann Surg Oncol 15 2195 205
4. MS Brady K Brown A Patel C Fisher W Marx 2006 A phase II trial of isolated limb infusion with melphalan and dactinomycin for regional melanoma and soft tissue sarcoma of the extremity Ann Surg Oncol 13 1123 29
5. P Lindner A Doubrovsky PC Kam JF Thompson 2002 Prognostic factors after isolated limb infusion with cytotoxic agents for melanoma Ann Surg Oncol 9 127 36
6. TY Cheng E Grubbs O Abdul-Wahab SY Leu CF Hung W Petros 2003 Marked variability of melphalan plasma drug levels during regional hyperthermic isolated limb perfusion Am J Surg 186 460 7
7. H Ehrsson S Eksborg A Lindfors 1986 Quantitative determination of melphalan in plasma by liquid chromatography after derivatization with N-acetylcysteine J Chromatogr Biomed Appl 380 222 8
8. J Wieberdink C Benckhuysen RP Braat EA van Slooten GA Olthuis 1982 Dosimetry in isolation perfusion of the limbs by assessment of perfused tissue volume and grading of toxic tissue reactions Eur J Cancer Clin Oncol 18 905 10
9. Fraker DL. Hyperthermic regional perfusion for melanoma of the limbs. In: Balch CM, Houghton AN, Sober AJ, Soong S, editors. Cutaneous Melanoma. St. Louis, MO: Quality Medical, 1998;281-300.
10. AW Boddie H Briele F Krementz 1992 A phase I study of melphalan in 40 C isolated limb perfusion using packed red blood cells and lactated ringers perfusate Proc ASCO 11 351
11. ET Krementz RD Carter CM Sutherlan JH Muchmore RF Ryan O Creech Jr 1994 Regional chemotherapy for melanoma: a 35-year experience Ann Surg 220 520 35
12. MS Roberts ZY Wu GA Siebert JF Thompson BM Smithers 2001 Saturable dose-response relationships for melphalan in melanoma treatment by isolated limb infusion in the nude rat Melanoma Res 11 611 8
13. HM Kroon M Moncrieff PC Kam JF Thompson 2008 Outcomes following isolated limb infusion for melanoma: a 14-year experience Ann Surg Oncol 15 3003 13
14. Beasley GM, Caudle A, Peterson RP, McMahon, N, Mosca P, Zager J, et al. A multi-institutional experience of isolated limb infusion: defining response and toxicity in the United States. Presented in part at the Southern Surgical Association's Annual Meeting, West Palm Beach, FL, 2008.
15. OI Abdel-Wahab E Grubbs B Viglianti TY Cheng T Ueno S Ko 2004 The role of hyperthermia in regional alkylating agent chemotherapy Clin Cancer Res 10 5919 29
16. B Hildebrandt P Wust O Ahlers A Dieing G Sreenivasa T Kerner 2002 The cellular and molecular basis of hyperthermia Crit Rev Oncol Hematol 43 33 56
17. JS Stehlin 1969 Hyperthermic perfusion with chemotherapy for cancers of the extremity Surg Gynecol Obstet 129 305 8
18. AL Skene AS Bulman TF Williams JM Thomas G Westbury 1990 Hyperthermic isolated limb perfusion with melphalan in the treatment of advanced malignant melanoma of the lower limb Br J Surg 77 765
19. FK Storm DL Morton 1985 Value of therapeutic hyperthermic limb perfusion in advanced recurrent melanoma of the lower extremity Am J Surg 150 32 35
20. DR Minor RE Allen D Alberts YM Peng G Tardelli J Hutchinson 1985 A clinical and pharmacokinetic study of isolated limb perfusion with heat and melphalan for melanoma Cancer 55 2638 44
21. Beasley GM, McMahon N, Sanders G, Zipfel P, Augustine C, Petros W, et al. A Phase I study of systemic ADH-1 in combination with melphalan via isolated limb infusion in patients with locally advanced in-transit malignant melanoma. ASCO abstract June 2008, 9013, 486.
22. EM Noorda BC Vrouenraets OE Nieweg JM Klaase J van der Zee BB Kroon 2003 Long-term results of a double perfusion schedule using high dose hyperthermia and melphalan sequentially in extensive melanoma of the lower limb Melanoma Res 13 395 9
23. WM Klop BC Vrouenraets BN van Geel AM Eggermont JM Klaase OE Nieweg 1996 Repeat isolated limb perfusion with melphalan for recurrent melanoma of the limbs J Am Coll Surg 182 467 72
24. JM Klaase BB Kroon AN Van Geel AM Eggermont HR Franklin JA van Dongen 1994 Is there an indication for a double perfusion schedule with melphalan for patients with recurrent melanoma of the limbs? Melanoma Res 4 13 6
25. JM Klaase BB Kroon AN van Geel AM Eggermont HR Franklin JA van Dongen 1993 A retrospective comparative study evaluating the results of a single-perfusion versus double-perfusion schedule with melphalan in patients with recurrent melanoma of the lower limb Cancer 71 2990 4
26. BB Kroon JM Klaase BN van Geel AM Eggermont HR Franklin JA van Dongen 1993 Results of a double perfusion schedule with melphalan in patients with melanoma of the lower limb Eur J Cancer 29A 325 8
27. P Lindner JF Thompson JHW De Wilt M Colman PC Kam 2004 Double isolated limb infusion for recurrent and metastatic limb melanoma Eur J Surg Oncol 30 433 9