Stimulation of κ-opioid receptor reduces isoprenaline-induced cardiac hypertrophy and fibrosis

European Journal of Pharmacology

Volumn 607, Issue 1-3, 2009, Pages 135-142

  Yin, Wen ^a   Zhang, Peng ^a   Huang, Jing Hui ^b   Zhang, Quan Yu ^b   Fan, Rong ^b   Li, Juan ^b   Zhou, Jing Jun ^b   Hu, Yu Zhen ^b   Guo, Hai Tao ^b   Zhang, Shu Miao ^b   Wang, Yue Min ^b   Kaye, Alan David ^c   Gu, Chun Hu ^a   Liu, Jin Cheng ^a   Cheng, Liang ^a   Cui, Qin ^a   Yi, Ding Hua ^a   Pei, Jian Ming ^a,b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

opioid receptor; Cardiac fibrosis; Cardiac hypertrophy; U50,488H

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; BETA ADRENERGIC RECEPTOR; CALCIUM; CALCIUM CHANNEL L TYPE; COLLAGEN TYPE 1; COLLAGEN TYPE 3; FIBRONECTIN; ISOPRENALINE; KAPPA OPIATE RECEPTOR; NORBINALTORPHIMINE; PROLINE; THYMIDINE;

AMINO ACID METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CALCIUM CELL LEVEL; CELL GROWTH; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; FIBROBLAST; HEART MUSCLE; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; HEART WEIGHT; MORPHOLOGY; NEWBORN; NONHUMAN; OPTICAL DENSITY; PRIORITY JOURNAL; RAT; TRANSMISSION ELECTRON MICROSCOPY;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ANIMALS; ANTIHYPERTENSIVE AGENTS; CALCIUM; CALCIUM CHANNELS, L-TYPE; CARDIOMEGALY; COLLAGEN TYPE I; COLLAGEN TYPE III; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBRONECTINS; FIBROSIS; HEART VENTRICLES; ISOPROTERENOL; MYOCYTES, CARDIAC; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, KAPPA;

EID: 62149127823     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.01.050     Document Type: Article

References (23)

1. Brouri F., Hanoun N., Mediani O., Saurini F., Hamon M., Vanhoutte P.M., and Lechat P. Blockade of beta 1- and desensitization of beta 2-adrenoceptors reduce isoprenaline-induced cardiac fibrosis. Eur. J. Pharmacol. 485 (2004) 227-234
2. Dhawan B.N., Cesselin F., Raghubir R., Reisine T., Bradley P.B., Portoghese P.S., and Hamon M. International Union of Pharmacology: XII. Classification of opioid receptors. Pharmacol. Rev. 48 (1996) 567-592
3. Eschehagen T., Mende U., Nose M., Schmitz W., Scholz H., Warnholtz A., and Wüstel J.M. Isoprenaline-induced increase in mRNA levels of inhibitory G-proteion alpha-subunits in rat heart. Naunyn-Schmiedebergs Arch. Pharmacol. 343 (1991) 609-615
4. Kuzmin A.V., Semenova S., Gerrits M.A., Zvartau E.E., and Van Ree J.M. Kappa-opioid receptor agonist U50,488H modulates cocaine and morphine self-administration in drug-naive rats and mice. Eur. J. Pharmacol. 321 (1997) 265-271
5. McLaughlin P.J. Regulation of DNA synthesis of myocardial and epicardial cells in developing rat heart by [Met5] enkephalin. Am. J. Physiol. 271 (1996) R122-R129
6. Pei J.M., Wang Y.M., Zhu Y.L., Chen M., and Wong T.M. Signaling pathway mediated by κ-opioid receptor is impaired in cardiac hypertrophy. Acta Pharmacol. Sin. 22 (2001) 887-895
7. Pepe S., Van den Brink O.W., Lakatta E.G., and Xiao R.P. Cross-talk of opioid peptide receptor and beta-adrenergic receptor signalling in the heart. Cardiovasc. Res. 63 (2004) 414-422
8. Sandoshima J., and Isumo S. The cellular and molecular response of cardiac myocyte to mechanical stress. Annu. Rev. Physiol. 59 (1997) 551-571
9. Sethi R., Saini H.K., Guo X., Wang X., Elimban V., and Dhalla N.S. Dependence of changes in beta-adrenoceptor signal transduction on type and stage of cardiac hypertrophy. J. Appl. Physiol. 102 (2007) 978-984
10. 1-adrenoceptor stimulation in the rat. Eur. J. Pharmacol. 555 (2007) 100-105
11. Sun X., Ma S., Zang Y.M., Lu S.Y., Guo H.T., Bi H., Wang Y.M., Ma H., Ma X.L., and Pei J.M. Vasorelaxing effect of U50,488H in pulmonary artery and underlying mechanism in rats. Life Sci. 78 (2006) 2516-2522
12. Ventura C., Guarnieri C., Vaona I., Campana G., Pintus G., and Spampinato S. Dynorphin gene expression and release in the myocardial cell. J. Biol. Chem. 269 (1994) 5384-5386
13. Ventura C., Pintus G., and Tadolini B. Opioid peptide gene expression in the myocardial cell. Trends Cardiovasc. Med. 8 (1998) 102-110
14. Wang G., Wang H., Yang Y., and Wong T.M. Kappa-opioid receptor stimulation inhibits growth of neonatal rat ventricular myocytes. Eur. J. Pharmacol. 498 (2004) 53-58
15. 2+ exchanger during the first minutes of reperfusion results in continued myocardial stunning. Eur. J. Pharmacol. 572 (2007) 1-11
16. Weil J., Benndorf R., Fredersdorf S., Griese D.P., and Eschenhagen T. Norepinephrine upregulates vascular endothelial growth factor in rat cardiac myocytes by a paracrine mechanism. Angiogenesis 6 (2003) 303-309
17. Weil J., Zolk O., Griepentrog J., Wenzel U., Zimmermann W.H., and Eschenhagen T. Alterations of the preproenkephalin system in cardiac hypertrophy and its role in atrioventricular conduction. Cardiovasc. Res. 69 (2006) 412-422
18. Wilson S.P., Klein R.L., Chang K.J., Gasparis M.S., Viveros O.H., and Yang W.H. Are opioid peptides co-transmitters in noradrenergic vesicles of sympathetic nerves?. Nature 288 (1980) 707-709
19. Wu G., Wang H., Yang J., Yang Y., Liu C., Jing L., and Wong T.M. Kappa-opioid receptor stimulation inhibits augmentation of Ca(2+) transient and hypertrophy induced by isoprenaline in neonatal rat ventricular myocytes-role of CaMKIIdelta(B). Eur. J. Pharmacol. 595 (2008) 52-57
20. Yu S.M., Tsai S.Y., Guh J.H., Ko F.N., Teng C.M., and Ou J.T. Mechanism of catecholamine-induced proliferation of vascular smooth muscle cells. Circulation 94 (1996) 547-554
21. Yu X.C., Diao T.M., Pei J.M., Zhang W.M., Wong N.S., and Wong T.M. Kappa-opioid receptor agonist inhibits the cholera toxin-sensitive G protein in the heart. J. Cardiovasc. Pharmacol. 38 (2001) 232-239
22. Zhang Y.G., Li Y.G., Liu B.G., Wei R.H., Wang D.M., Tan X.R., Bu D.F., Pang Y.Z., and Tang C.S. Urotensin II accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol. Acta Pharmacol. Sin. 28 (2007) 36-43
23. Zheng M., Han Q.D., and Xiao R.P. Distinct adrenergic receptor subtype signaling in the heart and their pathophysiological relevance. Acta Physiol. Sin. 56 (2004) 1-15