Epstein-Barr Nuclear Antigen 1 modulates replication of oriP-plasmids by impeding replication and transcription fork migration through the family of repeats

Virology Journal

Volumn 6, Issue , 2009, Pages

  Aiyar, Ashok ^a   Aras, Siddhesh ^a   Washington, Amber ^a   Singh, Gyanendra ^a   Luftig, Ronald B ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPSTEIN BARR NUCLEAR ANTIGEN 1; EPSTEIN BARR VIRUS ANTIGEN; UNCLASSIFIED DRUG; EBV ENCODED NUCLEAR ANTIGEN 1; EBV-ENCODED NUCLEAR ANTIGEN 1; VIRUS PROTEIN;

ANTIGEN BINDING; ANTIGEN EXPRESSION; ARTICLE; BINDING SITE; CONTROLLED STUDY; EPSTEIN BARR VIRUS; GENE REPLICATION; HUMAN; HUMAN CELL; MODULATION; ORIP GENE; PLASMID; PROBABILITY; REGULATORY MECHANISM; VIRUS GENE; WILD TYPE; CELL LINE; DNA REPLICATION; DNA REPLICATION ORIGIN; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NUCLEOTIDE REPEAT; PHYSIOLOGY; VIRUS REPLICATION;

HUMAN HERPESVIRUS 4;

BINDING SITES; CELL LINE; DNA REPLICATION; EPSTEIN-BARR VIRUS NUCLEAR ANTIGENS; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRUS 4, HUMAN; HUMANS; PLASMIDS; REPETITIVE SEQUENCES, NUCLEIC ACID; REPLICATION ORIGIN; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 62149126890     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/1743-422X-6-29     Document Type: Article

References (61)

1. Replication of latent Epstein-Barr virus genomes in Raji cells. A Adams, J Virol 1987 61 1743 1746 3033303
2. Epstein-Barr virus-derived plasmids replicate only once per cell cycle and are not amplified after entry into cells. JL Yates N Guan, J Virol 1991 65 483 488 1845903
3. Mapping genetic elements of Epstein-Barr virus that facilitate extrachromosomal persistence of Epstein-Barr virus-derived plasmids in human cells. S Lupton AJ Levine, Mol Cell Biol 1985 5 2533 2542 3016506
4. Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells. JL Yates N Warren B Sugden, Nature 1985 313 812 815 10.1038/313812a0 2983224
5. Definition of the sequence requirements for binding of the EBNA-1 protein to its palindromic target sites in Epstein-Barr virus DNA. RF Ambinder WA Shah DR Rawlins GS Hayward SD Hayward, J Virol 1990 64 2369 2379 2157891
6. Sequence-specific DNA binding of the Epstein-Barr virus nuclear antigen (EBNA-1) to clustered sites in the plasmid maintenance region. DR Rawlins G Milman SD Hayward GS Hayward, Cell 1985 42 859 868 10.1016/0092-8674(85)90282-X 2996781
7. Human DNA replication initiation factors, ORC and MCM, associate with oriP of Epstein-Barr virus. B Chaudhuri H Xu I Todorov A Dutta JL Yates, Proc Natl Acad Sci USA 2001 98 10085 10089 11517328 10.1073/pnas.181347998
8. Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin. SK Dhar K Yoshida Y Machida P Khaira B Chaudhuri JA Wohlschlegel M Leffak J Yates A Dutta, Cell 2001 106 287 296 10.1016/S0092-8674(01)00458-5 11509178
9. Human origin recognition complex binds to the region of the latent origin of DNA replication of Epstein-Barr virus. A Schepers M Ritzi K Bousset E Kremmer JL Yates J Harwood JF Diffley W Hammerschmidt, EMBO J 2001 20 4588 4602 11500385 10.1093/emboj/20.16.4588
10. RNA-dependent recruitment of the origin recognition complex. J Norseen A Thomae V Sridharan A Aiyar A Schepers PM Lieberman, EMBO J 2008 27 3024 3035 10.1038/emboj.2008.221 18946490
11. The plasmid replicon of EBV consists of multiple cis-acting elements that facilitate DNA synthesis by the cell and a viral maintenance element. A Aiyar C Tyree B Sugden, EMBO J 1998 17 6394 6403 9799247 10.1093/emboj/17.21.6394
12. Isolation of human sequences that replicate autonomously in human cells. PJ Krysan SB Haase MP Calos, Mol Cell Biol 1989 9 1026 1033 2542763
13. Functional domains of Epstein-Barr virus nuclear antigen EBNA-1. RF Ambinder MA Mullen YN Chang GS Hayward SD Hayward, J Virol 1991 65 1466 1478 1847464
14. Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein, EBNA1, bound to DNA. A Bochkarev JA Barwell RA Pfuetzner E Bochkareva L Frappier AM Edwards, Cell 1996 84 791 800 10.1016/S0092-8674(00) 81056-9 8625416
15. Two Epstein-Barr viral nuclear neoantigens distinguished by gene transfer, serology, and chromosome binding. EA Grogan WP Summers S Dowling D Shedd L Gradoville G Miller, Proc Natl Acad Sci USA 1983 80 7650 7653 6324183 10.1073/pnas.80.24.7650
16. Mapping EBNA-1 domains involved in binding to metaphase chromosomes. V Marechal A Dehee R Chikhi-Brachet T Piolot M Coppey-Moisan JC Nicolas, J Virol 1999 73 4385 4392 10196336
17. Metaphase chromosome tethering is necessary for the DNA synthesis and maintenance of oriP plasmids but is insufficient for transcription activation by Epstein-Barr nuclear antigen 1. J Sears J Kolman GM Wahl A Aiyar, J Virol 2003 77 11767 11780 14557661 10.1128/JVI.77.21.11767-11780.2003
18. The amino terminus of Epstein-Barr Virus (EBV) nuclear antigen 1 contains AT hooks that facilitate the replication and partitioning of latent EBV genomes by tethering them to cellular chromosomes. J Sears M Ujihara S Wong C Ott J Middeldorp A Aiyar, J Virol 2004 78 11487 11505 15479791 10.1128/JVI.78.21. 11487-11505.2004
19. Maintenance of Epstein-Barr virus (EBV) oriP-based episomes requires EBV-encoded nuclear antigen-1 chromosome-binding domains, which can be replaced by high-mobility group-I or histone H1. SC Hung MS Kang E Kieff, Proc Natl Acad Sci USA 2001 98 1865 1870 11172042 10.1073/pnas.031584698
20. Stability without a centromere. MP Calos, Proc Natl Acad Sci USA 1998 95 4084 4085 9539691 10.1073/pnas.95.8.4084
21. The coupling of synthesis and partitioning of EBV's plasmid replicon is revealed in live cells. A Nanbo A Sugden B Sugden, EMBO J 2007 26 4252 4262 17853891 10.1038/sj.emboj.7601853
22. The Epstein-Barr virus origin of plasmid replication, oriP, contains both the initiation and termination sites of DNA replication. TA Gahn CL Schildkraut, Cell 1989 58 527 535 10.1016/0092-8674(89)90433-9 2547525
23. Role of the EBNA-1 protein in pausing of replication forks in the Epstein-Barr virus genome. OV Ermakova L Frappier CL Schildkraut, J Biol Chem 1996 271 33009 33017 10.1074/jbc.271.51.33009 8955146
24. The spacing between adjacent binding sites in the family of repeats affects the functions of Epstein-Barr nuclear antigen 1 in transcription activation and stable plasmid maintenance. C Hebner J Lasanen S Battle A Aiyar, Virology 2003 311 263 274 10.1016/S0042-6822(03)00122-3 12842617
25. The cis-acting family of repeats can inhibit as well as stimulate establishment of an oriP replicon. ER Leight B Sugden, J Virol 2001 75 10709 10720 11602712 10.1128/JVI.75.22.10709-10720.2001
26. J Sambrook EF Fritsch T Maniatis, Molecular Cloning: A Laboratory Manual Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press 2 1989
27. Fusions between Epstein-Barr viral nuclear antigen-1 of Epstein-Barr virus and the large T-antigen of simian virus 40 replicate their cognate origins. A Aiyar B Sugden, J Biol Chem 1998 273 33073 33081 10.1074/jbc.273.49. 33073 9830062
28. Dominant-negative inhibitors of EBNA-1 of Epstein-Barr virus. AL Kirchmaier B Sugden, J Virol 1997 71 1766 1775 9032305
29. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. FL Graham J Smiley WC Russell R Nairn, J Gen Virol 1977 36 59 74 10.1099/0022-1317-36-1-59 886304
30. Selective extraction of polyoma DNA from infected mouse cell cultures. B Hirt, J Mol Biol 1967 26 365 369 10.1016/0022-2836(67)90307-5 4291934
31. DNA replication of human papillomavirus type 31 is modulated by elements of the upstream regulatory region that lie 5' of the minimal origin. WG Hubert T Kanaya LA Laimins, J Virol 1999 73 1835 1845 9971761
32. Detection of specific sequences among DNA fragments separated by gel electrophoresis. EM Southern, J Mol Biol 1975 98 503 517 10.1016/S0022-2836(75) 80083-0 1195397
33. Firefly luciferase gene: structure and expression in mammalian cells. JR de Wet KV Wood M DeLuca DR Helinski S Subramani, Mol Cell Biol 1987 7 725 737 3821727
34. DNA sequence and expression of the B95-8 Epstein-Barr virus genome. R Baer AT Bankier MD Biggin PL Deininger PJ Farrell TJ Gibson G Hatfull GS Hudson SC Satchwell C Seguin, Nature 1984 310 207 211 10.1038/310207a0 6087149
35. Transcription inhibits the replication of autonomously replicating plasmids in human cells. SB Haase SS Heinzel MP Calos, Mol Cell Biol 1994 14 2516 2524 8139554
36. Dissection of mammalian replicators by a novel plasmid stability assay. T Hashizume N Shimizu, J Cell Biochem 2007 101 552 565 10.1002/jcb.21210 17226771
37. Head-on collision between a DNA replication apparatus and RNA polymerase transcription complex. B Liu BM Alberts, Science 1995 267 1131 1137 10.1126/science.7855590 7855590
38. Sap1p binds to Ter1 at the ribosomal DNA of Schizosaccharomyces pombe and causes polar replication fork arrest. G Krings D Bastia, J Biol Chem 2005 280 39135 39142 10.1074/jbc.M508996200 16195226
39. swi1- and swi3-dependent and independent replication fork arrest at the ribosomal DNA of Schizosaccharomyces pombe. G Krings D Bastia, Proc Natl Acad Sci USA 2004 101 14085 14090 15371597 10.1073/pnas.0406037101
40. DNA replication fork pause sites dependent on transcription. AM Deshpande CS Newlon, Science 1996 272 1030 1033 10.1126/science.272.5264.1030 8638128
41. Cooperative roles of vertebrate Fbh1 and Blm DNA helicases in avoidance of crossovers during recombination initiated by replication fork collapse. M Kohzaki A Hatanaka E Sonoda M Yamazoe K Kikuchi N Vu Trung D Szuts JE Sale H Shinagawa M Watanabe S Takeda, Mol Cell Biol 2007 27 2812 2820 17283053 10.1128/MCB.02043-06
42. Two major replicating simian virus 40 chromosome classes. Synchronous replication fork movement is associated with bound large T antigen during elongation. LC Tack GN Proctor, J Biol Chem 1987 262 6339 6349 3032963
43. Simian virus 40 large T antigen DNA helicase. Characterization of the ATPase-dependent DNA unwinding activity and its substrate requirements. M Wiekowski MW Schwarz H Stahl, J Biol Chem 1988 263 436 442 2826446
44. Visualization of DNA replication on individual Epstein-Barr virus episomes. P Norio CL Schildkraut, Science 2001 294 2361 2364 10.1126/science.1064603 11743204
45. Plasticity of DNA replication initiation in Epstein-Barr virus episomes. P Norio CL Schildkraut, PLoS Biol 2004 2 e152 15208711 10.1371/journal.pbio. 0020152
46. Initiation of latent DNA replication in the Epstein-Barr virus genome can occur at sites other than the genetically defined origin. RD Little CL Schildkraut, Mol Cell Biol 1995 15 2893 2903 7739569
47. Identifying a property of origins of DNA synthesis required to support plasmids stably in human cells. CY Wang B Sugden, Proc Natl Acad Sci USA 2008 105 9639 9644 18621728 10.1073/pnas.0801378105
48. Deregulated replication licensing causes DNA fragmentation consistent with head-to-tail fork collision. IF Davidson A Li JJ Blow, Mol Cell 2006 24 433 443 17081992 10.1016/j.molcel.2006.09.010
49. Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest. LC Huang KC Clarkin GM Wahl, Proc Natl Acad Sci USA 1996 93 4827 4832 8643488 10.1073/pnas.93.10.4827
50. NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse. KC Manthey S Opiyo JG Glanzer D Dimitrova J Elliott GG Oakley, J Cell Sci 2007 120 4221 4229 10.1242/jcs.004580 18003706
51. Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects. JM Sogo M Lopes M Foiani, Science 2002 297 599 602 10.1126/science.1074023 12142537
52. Molecular coevolution of mammalian ribosomal gene terminator sequences and the transcription termination factor TTF-I. R Evers I Grummt, Proc Natl Acad Sci USA 1995 92 5827 5831 7597036 10.1073/pnas.92.13.5827
53. Limited proteolysis unmasks specific DNA-binding of the murine RNA polymerase I-specific transcription termination factor TTFI. A Smid M Finsterer I Grummt, J Mol Biol 1992 227 635 647 10.1016/0022-2836(92)90213-4 1404380
54. Epstein-Barr virus small RNA (EBER) genes: unique transcription units that combine RNA polymerase II and III promoter elements. JG Howe MD Shu, Cell 1989 57 825 834 10.1016/0092-8674(89)90797-6 2541926
55. Upstream basal promoter element important for exclusive RNA polymerase III transcription of the EBER 2 gene. JG Howe MD Shu, Mol Cell Biol 1993 13 2655 2665 8386314
56. Nuclear factor 1 (NF1) affects accurate termination and multiple-round transcription by human RNA polymerase III. Z Wang L Bai YJ Hsieh RG Roeder, EMBO J 2000 19 6823 6832 11118217 10.1093/emboj/19.24.6823
57. An EBNA-1-dependent enhancer acts from a distance of 10 kilobase pairs to increase expression of the Epstein-Barr virus LMP gene. TA Gahn B Sugden, J Virol 1995 69 2633 2636 7884916
58. oriP is essential for EBNA gene promoter activity in Epstein-Barr virus-immortalized lymphoblastoid cell lines. MT Puglielli M Woisetschlaeger SH Speck, J Virol 1996 70 5758 5768 8709191
59. trans activation of an Epstein-Barr viral transcriptional enhancer by the Epstein-Barr viral nuclear antigen 1. D Reisman B Sugden, Mol Cell Biol 1986 6 3838 3846 3025615
60. Transcriptional activation by EBV nuclear antigen 1 is essential for the expression of EBV's transforming genes. M Altmann D Pich R Ruiss J Wang B Sugden W Hammerschmidt, Proc Natl Acad Sci USA 2006 103 14188 14193 16966603 10.1073/pnas.0605985103
61. Multiple EBNA1-binding sites are required to form an EBNA1-dependent enhancer and to activate a minimal replicative origin within oriP of Epstein-Barr virus. DA Wysokenski JL Yates, J Virol 1989 63 2657 2666 2542579