Silencing of genes required for glycosylphosphatidylinositol anchor biosynthesis in Burkitt lymphoma

Experimental Hematology

Volumn 37, Issue 4, 2009, Pages

  Hu, Rong ^a   Mukhina, Galina L ^a   Lee, Soo Hee ^a   Jones, Richard J ^b   Englund, Paul T ^a   Brown, Patrick ^b   Sharkis, Saul J ^b   Buckley, J Thomas ^c   Brodsky, Robert A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c UNIVERSITY OF VICTORIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AEROLYSIN; DNA; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL GLYCAN ANCHOR PROTEIN CLASS A; PHOSPHATIDYLINOSITOL GLYCAN ANCHOR PROTEIN CLASS Y; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; BURKITT LYMPHOMA; CELL FREE SYSTEM; CELL POPULATION; CELL SURFACE; CELL TYPE; CONTROLLED STUDY; DAUDI CELL; FLOW CYTOMETRY; GENE MUTATION; GENE SEQUENCE; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LYMPHOMA CELL LINE; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; PROTEIN METHYLATION; QUANTITATIVE ASSAY; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM;

EID: 62149100368     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2009.01.003     Document Type: Article

References (45)

1. Low M.G., and Saltiel A.R. Structural and functional roles of glycosyl-phosphatidylinositol in membranes. Science 239 (1988) 268-275
2. Udenfriend S., and Kodukula K. How glycosylphosphatidylinositol-anchored membrane proteins are made. Annu Rev Biochem 64 (1995) 563-591
3. Kinoshita T., and Inoue N. Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis. Curr Opin Chem Biol 4 (2000) 632-638
4. Diep D.B., Nelson K.L., Raja S.M., Pleshak E.N., and Buckley J.T. Glycosylphosphatidylinositol anchors of membrane glycoproteins are binding determinants for the channel-forming toxin aerolysin. J Biol Chem 273 (1998) 2355-2360
5. Brodsky R.A., Mukhina G.L., Nelson K.L., Lawrence T.S., Jones R.J., and Buckley J.T. Resistance of paroxysmal nocturnal hemoglobinuria cells to the glycosylphosphatidylinositol-binding toxin aerolysin. Blood 93 (1999) 1749-1756
6. Miyata T., Takeda J., Iida Y., et al. The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis. Science 259 (1993) 1318-1320
7. Inoue N., Watanabe R., Takeda J., and Kinoshita T. PIG-C, one of the three human genes involved in the first step of glycosylphosphatidylinositol biosynthesis is a homologue of Saccharomyces cerevisiae GPI2. Biochem Biophys Res Commun 226 (1996) 193-199
8. Kamitani T., Chang H.M., Rollins C., Waneck GL., and Yeh ET. Correction of the class H defect in glycosylphosphatidylinositol anchor biosynthesis in Ltk- cells by a human cDNA clone. J Biol Chem 268 (1993) 20733-20736
9. Tiede A., Schubert J., Nischan C., et al. Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants. Biochem J 15 334(Pt 3) (1998) 609-616
10. Watanabe R., Inoue N., Westfall B., et al. The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1. EMBO J 17 (1998) 877-885
11. Murakami Y., Siripanyaphinyo U., Hong Y., Tashima Y., Maeda Y., and Kinoshita T. The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component. Mol Biol Cell 16 (2005) 5236-5246
12. Watanabe R., Murakami Y., Marmor M.D., et al. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. EMBO J 19 (2000) 4402-4411
13. Watanabe R., Ohishi K., Maeda Y., Nakamura N., and Kinoshita T. Mammalian PIG-L and its yeast homologue Gpi12p are N-acetylglucosaminylphosphatidylinositol de-N-acetylases essential in glycosylphosphatidylinositol biosynthesis. Biochem J 339 Pt 1 (1999) 185-192
14. Sharma D.K., Vidugiriene J., Bangs J.D., and Menon A.K. A cell-free assay for glycosylphosphatidylinositol anchoring in African trypanosomes. Demonstration of a transamidation reaction mechanism. J Biol Chem 274 (1999) 16479-16486
15. Tartakoff A.M., and Singh N. How to make a glycoinositol phospholipid anchor. Trends Biochem Sci 17 (1992) 470-473
16. Singh N., Singleton D., and Tartakoff A.M. Anchoring and degradation of glycolipid-anchored membrane proteins by L929 versus by LM-TK- mouse fibroblasts: implications for anchor biosynthesis. Mol Cell Biol 11 (1991) 2362-2374
17. Brodsky RA. Paroxysmal nocturnal hemoglobinuria. In: Hoffman R, Benz EJ Jr, Shattil SJ, et al., eds. Hematology: Basic Principles and Practice. 4th ed. Philadelphia: Elsevier Churchill Livingstone; 2005. p. 419-427.
18. Moyo V.M., Mukhina G.L., Garrett E.S., and Brodsky R.A. Natural history of paroxysmal nocturnal hemoglobinuria using modern diagnostic assays. Br J Haematol 126 (2004) 133-138
19. Brodsky R.A. Narrative review: paroxysmal nocturnal hemoglobinuria: the physiology of complement-related hemolytic anemia. Ann Intern Med 148 (2008) 587-595
20. Brodsky R.A., Mukhina G.L., Li S., et al. Improved detection and characterization of paroxysmal nocturnal hemoglobinuria using fluorescent aerolysin. Am J Clin Pathol 114 (2000) 459-466
21. Mukhina G.L., Buckley J.T., Barber J.P., Jones R.J., and Brodsky R.A. Multilineage glycosylphosphatidylinositol anchor deficient hematopoiesis in untreated aplastic anemia. Br J Haematol 115 (2001) 476-482
22. Takahaski M., Takeda J., Hirose S., et al. Deficient biosynthesis of N-acetylglucosaminyl-phosphatidylinositol, the first intermediate of glycosyl phosphatidylinositol anchor biosynthesis, in cell lines established from patients with paroxysmal nocturnal hemoglobinuria. J Exp Med 177 (1993) 517-521
23. Bessler M., Mason P.J., Hillmen P., et al. Paroxysmal nocturnal haemoglobinuria (PNH) is caused by somatic mutations in the PIG-A gene. EMBO J 13 (1994) 110-117
24. Nagarajan S., Brodsky R., Young N.S., and Medof M.E. Genetic defects underlying paroxysmal nocturnal hemoglobinuria that arises out of aplastic anemia. Blood 86 (1995) 4656-4661
25. Bessler M., Hillmen P., Longo L., Luzzatto L., and Mason P.J. Genomic organization of the X-linked gene (PIG-A) that is mutated in paroxysmal nocturnal haemoglobinuria and of a related autosomal pseudogene mapped to 12q21. Hum Mol Genet 43 (1994) 751-757
26. Rawstron A.C., Rollinson S.J., Richards S., et al. The PNH phenotype cells that emerge in most patients after CAMPATH-1H therapy are present prior to treatment. Br J Haematol 107 (1999) 148-153
27. Araten D.J., Nafa K., Pakdeesuwan K., and Luzzatto L. Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals. Proc Natl Acad Sci U S A 96 (1999) 5209-5214
28. Ware R.E., Pickens C.V., DeCastro C.M., and Howard T.A. Circulating PIG-A mutant T lymphocytes in healthy adults and patients with bone marrow failure syndromes. Exp Hematol 29 (2001) 1403-1409
29. Hu R., Mukhina G.L., Piantadosi S., Barber J.P., Jones R.J., and Brodsky R.A. PIG-A mutations in normal hematopoiesis. Blood 105 (2005) 3848-3854
30. Taylor V.C., Sims M., Brett S., and Field M.C. Antibody selection against CD52 produces a paroxysmal nocturnal haemoglobinuria phenotype in human lymphocytes by a novel mechanism. Biochem J 322 Pt 3 (1997) 919-925
31. Rowan W.C., Hale G., Tite J.P., and Brett S.J. Cross-linking of the CAMPATH-1 antigen (CD52) triggers activation of normal human T lymphocytes. Int Immunol 7 (1995) 69-77
32. Hatanaka M., Seya T., Matsumoto M., et al. Mechanisms by which the surface expression of the glycosyl-phosphatidylinositol-anchored complement regulatory proteins decay-accelerating factor (CD55) and CD59 is lost in human leukaemia cell lines. Biochem J 314 Pt 3 (1996) 969-976
33. Rodig S.J., Abramson J.S., Pinkus G.S., et al. Heterogeneous CD52 expression among hematologic neoplasms: implications for the use of alemtuzumab (CAMPATH-1H). Clin Cancer Res 12 (2006) 7174-7179
34. Doering T.L., Masterson W.J., Englund P.T., and Hart G.W. Biosynthesis of the glycosyl phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein. Origin of the non-acetylated glucosamine. J Biol Chem 264 (1989) 11168-11173
35. Stevens V.L. Regulation of glycosylphosphatidylinositol biosynthesis by GTP. Stimulation of N-acetylglucosamine-phosphatidylinositol deacetylation. J Biol Chem 268 (1993) 9718-9724
36. Hirose S., Ravi L., Hazra S.V., and Medof M.E. Assembly and deacetylation of N-acetylglucosaminyl-plasmanylinositol in normal and affected paroxysmal nocturnal hemoglobinuria cells. Proc Natl Acad Sci U S A 88 (1991) 3762-3766
37. Herman J.G., and Baylin S.B. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349 (2003) 2042-2054
38. Sobering A.K., Watanabe R., Romeo M.J., et al. Yeast Ras regulates the complex that catalyzes the first step in GPI-anchor biosynthesis at the ER. Cell 117 (2004) 637-648
39. Maeda Y., Watanabe R., Harris C.L., et al. PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER. EMBO J 20 (2001) 250-261
40. Tisdale E.J., Schimenti J.C., and Tartakoff A.M. Sodium butyrate causes reexpression of three membrane proteins on glycolipid-anchoring mutants. Somat Cell Mol Genet 17 (1991) 349-357
41. Ohannesian D.W., Lotan D., Thomas P., et al. Carcinoembryonic antigen and other glycoconjugates act as ligands for galectin-3 in human colon carcinoma cells. Cancer Res 55 (1995) 2191-2199
42. Almeida A.M., Murakami Y., Layton D.M., et al. Hypomorphic promoter mutation in PIGM causes inherited glycosylphosphatidylinositol deficiency. Nat Med 12 (2006) 846-851
43. Almeida A.M., Murakami Y., Baker A., et al. Targeted therapy for inherited GPI deficiency. N Engl J Med 356 (2007) 1641-1647
44. Gordon V.M., Nelson K.L., Buckley J.T., et al. Clostridium septicum alpha toxin uses glycosylphosphatidylinositol-anchored protein receptors. J Biol Chem 17 274 (1999) 27274-27280
45. Nagajothi N., Matsui W.H., Mukhina G.L., and Brodsky R.A. Enhanced cytotoxicity of rituximab following genetic and biochemical disruption of glycosylphosphatidylinositol anchored proteins. Leuk Lymphoma 45 (2004) 795-799