Components derived from Pelargonium stimulate macrophage killing of Mycobacterium species

Journal of Applied Microbiology

Volumn 106, Issue 4, 2009, Pages 1184-1193

  Kim, C E ^a   Griffiths, W J ^b   Taylor, P W ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b SWANSEA UNIVERSITY   (United Kingdom)

Author keywords

Macrophage; Mycobacterium fortuitum; Mycobacterium tuberculosis; Pelargonium reniforme; Umckaloabo

Indexed keywords

BIOASSAY; FLAVONOIDS; PLANT EXTRACTS; TUBES (COMPONENTS);

BIOASSAY-GUIDED FRACTIONATION; GALLIC ACIDS; GERANIACEAE; M. TUBERCULOSIS; METHYL GALLATE; MURINE MACROPHAGES; MYCOBACTERIA FORTUITUM; MYCOBACTERIUM TUBERCULOSIS; PELARGONIA RENIFORME; UMCKALOABO;

MACROPHAGES;

1 O [2 (4 METHOXYPHENYL)ETHYL 6 O GALLOYL]GLUCOPYRANOSIDE; GALLIC ACID; GALLIC ACID METHYL ESTER; GLUCOPYRANOSIDE; GLUCOSIDE; MYRICETIN; PELARGONIUM SIDOIDES EXTRACT; QUERCITIN 3 O BETA DEXTRO GLUCOSIDE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

BACTERIUM; BIOASSAY; BIOLOGICAL UPTAKE; DICOTYLEDON; DISEASE TREATMENT; FRACTIONATION; MEDICINAL PLANT; ORGANIC COMPOUND; PATHOGEN; PLANT EXTRACT; TUBERCULOSIS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL KINETICS; BIOASSAY; CONTROLLED STUDY; DRUG ISOLATION; FEMALE; FRACTIONATION; GEL PERMEATION CHROMATOGRAPHY; INTRACELLULAR KILLING; ION EXCHANGE CHROMATOGRAPHY; MACROPHAGE MIGRATION INHIBITION; MOUSE; MYCOBACTERIUM FORTUITUM; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PELARGONIUM; PELARGONIUM RENIFORME; SOLID PHASE EXTRACTION; SOXHLET EXTRACTION;

EID: 62149093525     PISSN: 13645072     EISSN: 13652672     Source Type: Journal    
DOI: 10.1111/j.1365-2672.2008.04085.x     Document Type: Article

References (23)

1. Chung, G.A.C., Aktar, Z., Jackson, S. Duncan, K. (1995) High-throughput screen for detecting antimycobacterial agents. Antimicrob Agents Chemother 39, 2235 2238.
2. Helmstädter, A. (1996) Umckaloabo - late vindication of a secret remedy. Pharm Historian 26, 2 4.
3. Kayser, O., Kolodziej, H. Kiderlen, A.F. (2001) Immunomodulatory principles of Pelargonium sidoides. Phytother Res 15, 122 126.
4. Kolodziej, H. (2000) Traditionally used Pelargonium species: chemistry and biological activity of Umckaloabo extracts and their constituents. Curr Top Phytochem 3, 77 93.
5. Kolodziej, H. (2002) Pelargonium reniforme and Pelargonium sidoides: their botany, chemistry and medicinal use. In Geranium and Pelargonium ed. Lis-Balchin, M. pp. 262 290 London : Taylor & Francis.
6. ®. Phytomedicine 14 (Suppl 6 9 17.
7. Kolodziej, H. Kiderlen, A.F. (2005) Antileishmanial activity and immune modulatory effects of tannins and related compounds on Leishmania parasitized RAW 264.7 cells. Phytochemistry 66, 2056 2071.
8. ® 7630. Phytomedicine 14 (Suppl 4 18 26.
9. Kolodziej, H., Kayser, O., Radtke, O.A., Kiderlen, A.F. Koch, E. (2003) Pharmacological profile of extracts of Pelargonium sidoides and their constituents. Phytomedicine 10 (Suppl 6 18 24.
10. Newsom, S.W.B. (2002) Stevens' cure: a secret remedy. J R Soc Med 95, 463 467.
11. Parti, R.P., Srivastava, S., Gachhui, R., Srivastava, K.K. Srivastava, R. (2005) Murine infection model for Mycobacterium fortuitum. Microb Infect 7, 349 355.
12. Sechehaye, A. (1929) The Treatment of Tuberculous Affections with Umckaloabo. London : B. Fraser.
13. Sechehaye, A. (1930) The Treatment of Pulmonary and Surgical Tuberculosis with Umckaloabo. London : B. Fraser.
14. Sechehaye, A. (1931) Umckaloabo and Tuberculosis: Reports Made to the General Conference of Romanisch-Swiss Physicians at the Meeting of the Geneva Medical Society. London : B. Fraser.
15. Seidel, V. Taylor, P.W. (2004) In vitro activity of extracts and constituents of Pelargonium against rapidly growing mycobacteria. Int J Antimicrob Agents 23, 613 619.
16. da Silva, T.R.M., de Freitas, J.R., Silva, Q.C., Figueira, C.P., Roxo, E., Leão, S.C., de Freitas, L.A.R. Veras, P.S.T. (2002) Virulent Mycobacterium fortuitum restricts NO production by a gamma-interferon-activated J774 cell line and phagosome-lysosome fusion. Infect Immun 70, 5628 5634.
17. Speert, D.P., Loh, B.A., Cabral, D.A. Salit, I.E. (1986) Nonopsonic phagocytosis of nonmucoid Pseudomonas aeruginosa by human neutrophils and moncyte-derived macrophages is correlated with bacterial piliation and hydrophobicity. Infect Immun 53, 207 212.
18. Taylor, P.W. (2003) Antimycobacterial activity of indigenous South African plants. S Afr Med J 93, 904 907.
19. Taylor, P.W., Maalim, S. Coleman, S. (2005) The strange story of Umckaloabo. Pharm J 275, 790 792.
20. Tomioka, H., Shimizu, T., Sato, K., Sano, C., Kamei, T., Emori, M. Saito, H. (2004) Comparative roles of macrophages and NK cells in the host innate resistance of mice to Mycobacterium fortuitum infection. J Infect 48, 74 80.
21. Williams, C.A., Newman, M. Gibby, M. (2000) The application of leaf phenolic evidence for systematic studies within the genus Pelargonium (Geraniaceae). Biochem Syst Ecol 28, 119 132.
22. Xie, J., Chen, L., Xi, C. Xu, X. (2003) Selective extraction of functional components derived from herb in plasma by using a molecularly imprinted polymer based on 2,2-bis(hydroxymethyl)butanol trimethacrylate. J Chromatogr B 788, 233 242.
23. Zhong, W.Z. (1998) Application of solid-phase extraction method in the development for determination of SEPA, an acronym for soft enhancement of percutaneous absorption, in human, rat, rabbit serum using GC-FID method. J Pharm Biomed Anal 16, 1179 1187.