CMV enhancer-promoter is preferentially active in exocrine cells in vivo

Transgenic Research

Volumn 18, Issue 2, 2009, Pages 309-314

  Vasey, D B ^a   Lillico, S G ^a   Sang, H M ^a   King, T J ^a   Whitelaw, C B A ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Cytomegalovirus; DNA vector; Exocrine; NF B; Transgene

Indexed keywords

GREEN FLUORESCENT PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ANIMAL; ARTICLE; CHICKEN; CYTOMEGALOVIRUS; ENHANCER REGION; GENE TRANSFER; GENE VECTOR; GENETIC TRANSCRIPTION; GENETICS; HUMAN; LENTIVIRINAE; METABOLISM; PROMOTER REGION; SWINE; TRANSGENE; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CHICKENS; CYTOMEGALOVIRUS; ENHANCER ELEMENTS, GENETIC; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; LENTIVIRUS; NF-KAPPA B; PROMOTER REGIONS, GENETIC; SWINE; TRANSCRIPTION, GENETIC; TRANSGENES;

CYTOMEGALOVIRUS; GALLUS GALLUS; LENTIVIRUS; SUIDAE;

EID: 62149087069     PISSN: 09628819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11248-008-9235-y     Document Type: Article

References (20)

1. BD Assogba BH Choi HM Rho 2002 Transcriptional activation of the promoter of human cytomegalovirus immediate early gene (CMV-IE) by the hepatitis B viral X protein (HBx) through the NF-kappaB site Virus Res 84 171 179 10.1016/S0168-1702(01)00445-2
2. CA Benedict A Angulo G Patterson S Ha H Huang M Messerle CF Ware P Ghazal 2004 Neutrality of the canonical NF-kappaB-dependent pathway for human and murine cytomegalovirus transcription and replication in vitro J Virol 78 741 750 10.1128/JVI.78.2.741-750.2004
3. M Boshart F Weber G Jahn K Dorsch-Hasler B Fleckenstein W Schaffner 1985 A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus Cell 41 521 530 10.1016/S0092-8674(85)80025-8
4. P Brandtzaeg IN Farstad FE Johansen HC Morton IN Norderhaug T Yamanaka 1999 The B-cell system of human mucosae and exocrine glands Immunol Rev 171 45 87 10.1111/j.1600-065X.1999.tb01342.x
5. MK Foecking H Hofstetter 1986 Powerful and versatile enhancer-promoter unit for mammalian expression vectors Gene 45 101 105 10.1016/0378-1119(86) 90137-X
6. A Fraldi E Zito F Annunziata A Lombardi M Cozzolino M Monti C Spampanato A Ballabio P Pucci R Sitia MP Cosma 2008 Multistep, sequential control of the trafficking and function of the multiple sulfatase deficiency gene product, SUMF1 by PDI, ERGIC-53 and ERp44 Hum Mol Genet 17 2610 2621 10.1093/hmg/ddn161
7. PA Furth L Hennighausen C Baker B Beatty R Woychick 1991 The variability in activity of the universally expressed human cytomegalovirus immediate early gene 1 enhancer/promoter in transgenic mice Nucleic Acids Res 19 6205 6208 10.1093/nar/19.22.6205
8. I Gruh S Wunderlich M Winkler K Schwanke J Heinke U Blomer A Ruhparwar B Rohde RK Li A Haverich U Martin 2008 Human CMV immediate-early enhancer: a useful tool to enhance cell-type-specific expression from lentiviral vectors J Gene Med 10 21 32 10.1002/jgm.1122
9. M Gustems E Borst CA Benedict C Perez M Messerle P Ghazal A Angulo 2006 Regulation of the transcription and replication cycle of human cytomegalovirus is insensitive to genetic elimination of the cognate NF-kappaB binding sites in the enhancer J Virol 80 9899 9904 10.1128/JVI.00640-06
10. J Kong SR Kim K Binley I Pata K Doi J Mannik J Zernant-Rajang O Kan S Iqball S Naylor JR Sparrow P Gouras R Allikmets 2008 Correction of the disease phenotype in the mouse model of Stargardt disease by lentiviral gene therapy Gene Ther 15 1311 1320 10.1038/gt.2008.78
11. MJ McGrew A Sherman FM Ellard SG Lillico HJ Gilhooley AJ Kingsman KA Mitrophanous H Sang 2004 Efficient production of germline transgenic chickens using lentiviral vectors EMBO Rep 5 728 733 10.1038/sj.embor.7400171
12. L Naldini U Blomer P Gallay D Ory R Mulligan FH Gage IM Verma D Trono 1996 In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector Science 272 263 267 10.1126/science.272.5259.263
13. A Pfeifer 2004 Lentiviral transgenesis Transgenic Res 13 513 522 10.1007/s11248-004-2735-5
14. F Prols F Ehehalt M Rodriguez-Niedenfuhr L He R Huang B Christ 2004 The role of Emx2 during scapula formation Dev Biol 275 315 324 10.1016/j.ydbio.2004. 08.003
15. A Ramezani TS Hawley RG Hawley 2000 Lentiviral vectors for enhanced gene expression in human hematopoietic cells Mol Ther 2 458 469 10.1006/mthe.2000. 0190
16. LC Sambucetti JM Cherrington GW Wilkinson ES Mocarski 1989 NF-kappa B activation of the cytomegalovirus enhancer is mediated by a viral transactivator and by T cell stimulation EMBO J 8 4251 4258
17. EV Schmidt G Christoph R Zeller P Leder 1990 The cytomegalovirus enhancer: a pan-active control element in transgenic mice Mol Cell Biol 10 4406 4411
18. A Tessitore A Faella T O'Malley G Cotugno M Doria T Kunieda G Matarese M Haskins A Auricchio 2008 Biochemical, pathological, and skeletal improvement of mucopolysaccharidosis VI after gene transfer to liver but not to muscle Mol Ther 16 30 37 10.1038/sj.mt.6300325
19. CB Whitelaw PA Radcliffe WA Ritchie A Carlisle FM Ellard RN Pena J Rowe AJ Clark TJ King KA Mitrophanous 2004 Efficient generation of transgenic pigs using equine infectious anaemia virus (EIAV) derived vector FEBS Lett 571 233 236 10.1016/j.febslet.2004.06.076
20. Q Zhou J Brown A Kanarek J Rajagopal DA Melton 2008 In vivo reprogramming of adult pancreatic exocrine cells to beta-cells Nature 455 627 632 10.1038/nature07314