Inhibition of RNA Polymerase III Transcription by BRCA1

Journal of Molecular Biology

Volumn 387, Issue 3, 2009, Pages 523-531

  Veras, Ingrid ^a   Rosen, Eliot M ^b   Schramm, Laura ^a  

^a ST JOHN'S UNIVERSITY   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

Author keywords

BRCA1; Brf1; Brf2; RNA polymerase III; TFIIIB

Indexed keywords

BRCA1 PROTEIN; DNA DIRECTED RNA POLYMERASE III; PROTEIN SUBUNIT; RNA POLYMERASE II; SMALL NUCLEAR RNA; TRANSFER RNA;

APOPTOSIS; ARTICLE; CELL CYCLE REGULATION; CELL GROWTH; CELL STRAIN HEK293; DNA REPAIR; ENZYME INHIBITION; HELA CELL; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RNA PROCESSING; RNA TRANSCRIPTION; RNA TRANSLATION; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION INITIATION; UBIQUITINATION;

SACCHAROMYCES CEREVISIAE;

EID: 62049085249     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.02.008     Document Type: Article

References (20)

1. Schramm L., and Hernandez N. Recruitment of RNA polymerase III to its target promoters. Genes Dev. 16 (2002) 2593-2620
2. Schramm L., Pendergrast P.S., Sun Y., and Hernandez N. Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters. Genes Dev. 14 (2000) 2650-2663
3. White R.J. RNA polymerase III transcription and cancer. Oncogene 23 (2004) 3208-3216
4. Woiwode A., Johnson S.A., Zhong S., Zhang C., Roeder R.G., Teichmann M., and Johnson D.L. PTEN represses RNA polymerase III-dependent transcription by targeting the TFIIIB complex. Mol. Cell. Biol. 28 (2008) 4204-4214
5. Morton J.P., Kantidakis T., and White R.J. RNA polymerase III transcription is repressed in response to the tumour suppressor ARF. Nucleic Acids Res. 35 (2007) 3046-3052
6. Felton-Edkins Z.A., Kenneth N.S., Brown T.R., Daly N.L., Gomez-Roman N., Grandori C., et al. Direct regulation of RNA polymerase III transcription by RB, p53 and c-Myc. Cell Cycle 2 (2003) 181-184
7. Sutcliffe J.E., Cairns C.A., McLees A., Allison S.J., Tosh K., and White R.J. RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130. Mol. Cell. Biol. 19 (1999) 4255-4261
8. Felton-Edkins Z.A., Fairley J.A., Graham E.L., Johnston I.M., White R.J., and Scott P.H. The mitogen-activated protein (MAP) kinase ERK induces tRNA synthesis by phosphorylating TFIIIB. EMBO J. 22 (2003) 2422-2432
9. Kennedy R.D., Quinn J.E., Johnston P.G., and Harkin D.P. BRCA1: mechanisms of inactivation and implications for management of patients. Lancet 360 (2002) 1007-1014
10. Rosen E.M., Fan S., and Ma Y. BRCA1 regulation of transcription. Cancer Lett. 236 (2006) 175-185
11. Kobor M.S., Simon L.D., Omichinski J., Zhong G., Archambault J., and Greenblatt J. A motif shared by TFIIF and TFIIB mediates their interaction with the RNA polymerase II carboxy-terminal domain phosphatase Fcp1p in Saccharomyces cerevisiae. Mol. Cell. Biol. 20 (2000) 7438-7449
12. Rollins J., Veras I., Cabarcas S., Willis I., and Schramm L. Human Maf1 negatively regulates RNA polymerase III transcription via the TFIIB family members Brf1 and Brf2. Int. J. Biol. Sci. 3 (2007) 292-302
13. Fan S., Yuan R., Ma Y.X., Meng Q., Goldberg I.D., and Rosen E.M. Mutant BRCA1 genes antagonize phenotype of wild-type BRCA1. Oncogene 20 (2001) 8215-8235
14. Jacob J., Cabarcas S., Veras I., Zaveri N., and Schramm L. The green tea component EGCG inhibits RNA polymerase III transcription. Biochem. Biophys. Res. Commun. 360 (2007) 778-783
15. Winter A.G., Sourvinos G., Allison S.J., Tosh K., Scott P.H., Spandidos D.A., and White R.J. RNA polymerase III transcription factor TFIIIC2 is overexpressed in ovarian tumors. Proc. Natl Acad. Sci. USA 97 (2000) 12619-12624
16. Cousineau I., and Belmaaza A. BRCA1 haploinsufficiency, but not heterozygosity for a BRCA1-truncating mutation, deregulates homologous recombination. Cell Cycle 6 (2007) 962-971
17. Deng C.X. BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution. Nucleic Acids Res. 34 (2006) 1416-1426
18. Cabart P., Chew H.K., and Murphy S. BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II. Oncogene 23 (2004) 5316-5329
19. Hu Y.F., and Li R. JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction. Genes Dev. 16 (2002) 1509-1517
20. Billack B., and Monteiro A.N. BRCA1 in breast and ovarian cancer predisposition. Cancer Lett. 227 (2005) 1-7