PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 296, Issue 2, 2009, Pages

  Thomas, James A ^a,c   Deaton, Rebecca A ^a,c   Hastings, Nicole E ^b,c   Shang, Yueting ^a,c   Moehle, Christopher W ^a,c   Eriksson, Ulf ^d   Topouzis, Stavros ^e,f   Wamhoff, Brian R ^a,b,c   Blackman, Brett R ^b,c   Owens, Gary K ^a,c  

^a UNIVERSITY OF VIRGINIA   (United States)

^b University of Virginia   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

^d LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

^e Univ of Virginia ^*  (United States)

^f UNIVERSITY OF PATRAS   (Greece)

Author keywords

Disturbed blood flow; Shear stress; Smooth muscle actin; Smooth muscle myosin heavy chain

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; APOLIPOPROTEIN C; KRUPPEL LIKE FACTOR 4; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MYOSIN HEAVY CHAIN; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PLATELET DERIVED GROWTH FACTOR DD; PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ACTIN; ACTIN BINDING PROTEIN; APOLIPOPROTEIN E; CALCIUM BINDING PROTEIN; CALPONIN; KRUPPEL LIKE FACTOR; LYMPHOKINE; MUSCLE PROTEIN; PDGFD PROTEIN, HUMAN; PDGFD PROTEIN, MOUSE; PROTEIN KINASE INHIBITOR; RECOMBINANT PROTEIN; SMOOTH MUSCLE ACTIN, RAT; TRANSCRIPTION FACTOR ELK 1; TRANSGELIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ARCH; ARTICLE; ASSAY; ATHEROSCLEROSIS; BLOOD FLOW; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOLOGY; DISEASE COURSE; ENDOTHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; INTIMA; MODULATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REPRESSOR GENE; SMOOTH MUSCLE FIBER; UPREGULATION; ANIMAL; C57BL MOUSE; CELL CULTURE; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; MECHANICAL STRESS; METABOLISM; MOUSE MUTANT; PATHOPHYSIOLOGY; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; REPORTER GENE; RNA INTERFERENCE; TIME; VASCULAR SMOOTH MUSCLE;

ACTINS; ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CALCIUM-BINDING PROTEINS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; ETS-DOMAIN PROTEIN ELK-1; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENES, REPORTER; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LYMPHOKINES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROFILAMENT PROTEINS; MUSCLE PROTEINS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; MYOSIN HEAVY CHAINS; PHENOTYPE; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PROMOTER REGIONS, GENETIC; PROTEIN KINASE INHIBITORS; PROTEIN MULTIMERIZATION; RATS; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; RECOMBINANT PROTEINS; REGIONAL BLOOD FLOW; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; STRESS, MECHANICAL; TIME FACTORS; UP-REGULATION;

EID: 61949283440     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00165.2008     Document Type: Article

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