Gender differences in the effects of antenatal betamethasone exposure on renal function in adult sheep

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 296, Issue 2, 2009, Pages

  Tang, Lijun ^a   Carey, Luke C ^a   Bi, Jianli ^a   Valego, Nancy ^a   Sun, Xiurong ^a   Deibel, Philip ^a   Perrott, James ^a   Figueroa, Jorge P ^a   Chappell, Mark C ^a   Rose, James C ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Angiotensin (1 7); Glomerular filtration rate; Prenatal steroid exposure; Sodium excretion; Sodium load

Indexed keywords

ANGIOTENSIN[1-7]; BETAMETHASONE ACETATE PLUS BETAMETHASONE SODIUM PHOSPHATE; ANGIOTENSIN I; ANGIOTENSIN I (1 7); ANGIOTENSIN I (1-7); ANTIINFLAMMATORY AGENT; BETAMETHASONE; CREATININE; PEPTIDE FRAGMENT; POTASSIUM; SODIUM;

ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW; BLOOD PRESSURE; CONTROLLED STUDY; FEMALE; GLOMERULUS FILTRATION RATE; KIDNEY FUNCTION; MALE; NONHUMAN; PRENATAL EXPOSURE; PRIORITY JOURNAL; SEX DIFFERENCE; SHEEP; SODIUM EXCRETION; SODIUM LOAD; AGE; AGING; ANIMAL; BLOOD; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DRUG EFFECT; GESTATIONAL AGE; GROWTH, DEVELOPMENT AND AGING; HYPERTENSION; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY; KIDNEY PLASMA FLOW; NATRIURESIS; PATHOPHYSIOLOGY; PREGNANCY; PROTEINURIA; URINE;

AGE FACTORS; AGING; ANGIOTENSIN I; ANIMALS; ANTI-INFLAMMATORY AGENTS; BETAMETHASONE; BLOOD PRESSURE; CREATININE; FEMALE; GESTATIONAL AGE; GLOMERULAR FILTRATION RATE; HYPERTENSION; INFUSIONS, INTRAVENOUS; KIDNEY; MALE; NATRIURESIS; PEPTIDE FRAGMENTS; POTASSIUM; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PROTEINURIA; RENAL PLASMA FLOW, EFFECTIVE; SEX FACTORS; SHEEP; SODIUM;

EID: 61949126409     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.90645.2008     Document Type: Article

References (58)

1. American Medical Association. NIH Consensus Development Conference 1995. Effects of corticosteroid for fetal maturation on perinatal outcomes. J Am Med Assoc 273: 413-418, 1995.
2. Boyd ND, Benediktsson H, Vimy MJ, Hooper DE, Lorscheider FL. Mercury from dental "silver" tooth fillings impairs sheep kidney function. Am J Physiol Regul Integr Comp Physiol 261: R1010-R1014, 1991.
3. Brandon AE, Boyce AC, Lumbers ER, Zimanyi MA, Bertram JF, Gibson KJ. Glomerular hypertrophy in offspring of subtotally nephrectomized ewes. Anat Rec (Hoboken) 291: 318-324, 2008.
4. Celsi G, Kistner A, Aizman R, Eklof AC, Ceccatelli S, de S, Jacobson SH. Prenatal dexamethasone causes oligonephronia, sodium retention, and higher blood pressure in the offspring. Pediatr Res 44: 317-322, 1998. (Pubitemid 28389985)
5. Chappell MC. Emerging evidence for a functional angiotensin-converting enzyme 2-angiotensin-(1-7)-MAS receptor axis: more than regulation of blood pressure? Hypertension 50: 596-599, 2007.
6. Chappell MC, Diz DI, Yunis C, Ferrario CM. Differential actions of angiotensin-(1-7) in the kidney. Kidney Int Suppl 68: S3-S6, 1998.
7. Crowley PA. Antenatal corticosteroid therapy: a meta-analysis of the randomized trials, 1972 to 1994. Am J Obstet Gynecol 173: 322-335, 1995.
8. + exchanger by dexamethasone. Am J Physiol Regul Integr Comp Physiol 292: R1230-R1235, 2007.
9. Davidson WD, Sackner MA. Simplification of the anthrone method for the deternination of inulin in clearance studies. J Lab Clin Med 62: 351-356, 1963.
10. Dodic M, Abouantoun T, O'Connor A, Wintour EM, Moritz KM. Programming effects of short prenatal exposure to dexamethasone in sheep. Hypertension 40: 729-734, 2002. (Pubitemid 35278611)
11. Dodic M, May CN, Wintour EM, Coghlan JP. An early prenatal exposure to excess glucocorticoid leads to hypertensive offspring in sheep. Clin Sci 94: 149-155, 1998. (Pubitemid 28052645)
12. Dodic M, Tersteeg M, Jefferies A, Wintour EM, Moritz K. Prolonged low-dose dexamethasone treatment, in early gestation, does not alter blood pressure or renal function in adult sheep. J Endocrinol 179: 275-280, 2003. (Pubitemid 37461357)
13. Figueroa JP, Jie Z. Blood pressure in prenatal betamethasone exposure in adult offspring in sheep (Abstract). Reprod Sci 15: 271A, 2008.
14. Figueroa JP, Acuna G, Rose JC, Massmann GA. Maternal antenatal steroid administration at 0.55 gestation increases arterial blood pressure in young adult sheep offspring (Abstract). J Soc Gynecol Invest 11: 358A, 2004.
15. Figueroa JP, Rose JC, Massmann GA, Zhang J, Acuna G. Alterations in fetal kidney development and elevations in arterial blood pressure in young adult sheep after clinical doses of antenatal glucocorticoids. Pediatr Res 58: 510-515, 2005. (Pubitemid 41254516)
16. Figueroa JP, Rose JC, Zhang J, Massmann GA. Single maternal betamethasone course at 0.55 of gestation decreases nephron number in late gestation fetal sheep (Abstract). J Soc Gynecol Invest Suppl 10: 292A, 2003.
17. Finken MJ, Keijzer-Veen MG, Dekker FW, Frolich M, Walther FJ, Romijn JA, van der Heijden BJ, Wit JM. Antenatal glucocorticoid treatment is not associated with long-term metabolic risks in individuals born before 32 weeks of gestation. Arch Dis Child Fetal Neonatal Ed 93: 442-447, 2008.
18. Gironacci MM, Coba MP, Pena C. Angiotensin-(1-7) binds at the type 1 angiotensin II receptors in rat renal cortex. Regul Pept 84: 51-54, 1999.
19. Guyton AC, Coleman TG, Cowley AV Jr, Scheel KW, Manning RD Jr, Norman RA Jr. Arterial pressure regulation. Overriding dominance of the kidneys in long-term regulation and in hypertension. Am J Med 52: 584-594, 1972.
20. Gwathmey-Williams T, Shaltout HA, Diz DI, Figueroa JP, Rose JC, Chappell MC. Steroid-induced fetal programming alters angiotensin II receptor subtype expression in the sheep kidney. FASEB J 22: 735-739, 2008.
21. Handa RK. Angiotensin-(1-7) can interact with the rat proximal tubule AT(4) receptor system. Am J Physiol Renal Physiol 277: F75-F83, 1999.
22. Handa RK. Metabolism alters the selectivity of angiotensin-(1-7) receptor ligands for angiotensin receptors. J Am Soc Nephrol 11: 1377-1386, 2000.
23. Handa RK, Krebs LT, Harding JW, Handa SE. Angiotensin IV AT4-receptor system in the rat kidney. Am J Physiol Renal Physiol 274: F290-F299, 1998.
24. Heller J, Kramer HJ, Maly J, Cervenka L, Horacek V. Effect of intrarenal infusion of angiotensin-(1-7) in the dog. Kidney Blood Press Res 23: 89-94, 2000.
25. Holstein-Rathlou NH, Christensen P, Leyssac PP. Effects of halothanenitrous oxide inhalation anesthesia and Inactin on overall renal and tubular function in Sprague-Dawley and Wistar rats. Acta Physiol Scand 114: 193-201, 1982.
26. Huang WL, Beazley LD, Quinlivan JA, Evans SF, Newnham JP, Dunlop SA. Effect of corticosteroids on brain growth in fetal sheep. Obstet Gynecol 94: 213-218, 1999.
27. Hutchison AS, O'Reilly DS, MacCuish AC. Albumin excretion rate, albumin concentration, and albumin/creatinine ratio compared for screening diabetics for slight albuminuria. Clin Chem 34: 2019-2021, 1988.
28. Jung K, Klotzek S, Schulze BD. Refinements of assays for low concentrations of inulin in serum. Nephron 54: 360-361, 1990. (Pubitemid 20097886)
29. Loria A, Reverte V, Salazar F, Saez F, Llinas MT, Salazar FJ. Changes in renal hemodynamics and excretory function induced by a reduction of ANG II effects during renal development. Am J Physiol Regul Integr Comp Physiol 293: R695-R700, 2007. (Pubitemid 47205052)
30. Martins JP, Monteiro JC, Paixao AD. Renal function in adult rats subjected to prenatal dexamethasone. Clin Exp Pharmacol Physiol 30: 32-37, 2003.
31. Massmann GA, Zhang J, Rose JC, Figueroa JP. Antenatal steroid administration at 0.55 of gestation alters sodium transporter expression in adult offspring in sheep (Abstract). J Soc Gynecol Investig 12: 44A, 2005.
32. Massmann GA, Zhang J, Rose JC, Figueroa JP. Acute and long-term effects of clinical doses of antenatal glucocorticoids in the developing fetal sheep kidney. J Soc Gynecol Investig 13: 174-180, 2006.
33. Moritz KM, Johnson K, Douglas-Denton R, Wintour EM, Dodic M. Maternal glucocorticoid treatment programs alterations in the renin-angiotensin system of the ovine fetal kidney. Endocrinology 143: 4455-4463, 2002. (Pubitemid 35239580)
34. Orlando R, Floreani M, Padrini R, Palatini P. Determination of inulin clearance by bolus intravenous injection in healthy subjects and ascitic patients: equivalence of systemic and renal clearances as glomerular filtration markers. Br J Clin Pharmacol 46: 605-609, 1998. (Pubitemid 28522126)
35. Ortiz LA, Quan A, Weinberg A, Baum M. Effect of prenatal dexamethasone on rat renal development. Kidney Int 59: 1663-1669, 2001. (Pubitemid 32336780)
36. Ortiz LA, Quan A, Zarzar F, Weinberg A, Baum M. Prenatal dexamethasone programs hypertension and renal injury in the rat. Hypertension 41: 328-334, 2003. (Pubitemid 36204910)
37. Rasmussen MS, Simonsen JA, Sandgaard NC, Hoilund-Carlsen PF, Bie P. Mechanisms of acute natriuresis in normal humans on low sodium diet. J Physiol Lond 546: 591-603, 2003. (Pubitemid 36175994)
38. Ruggenenti P, Gaspari F, Perna A, Remuzzi G. Cross sectional longitudinal study of spot morning urine protein:creatinine ratio, 24 hour urine protein excretion rate, glomerular filtration rate, and end stage renal failure in chronic renal disease in patients without diabetes. Br Med J 316: 504-509, 1998. (Pubitemid 28120955)
39. Saez F, Castells MT, Zuasti A, Salazar F, Reverte V, Loria A, Salazar FJ. Sex differences in the renal changes elicited by angiotensin II blockade during the nephrogenic period. Hypertension 49: 1429-1435, 2007. (Pubitemid 46809390)
40. Salazar F, Reverte V, Saez F, Loria A, Llinas MT, Salazar FJ. Ageand sodium-sensitive hypertension and sex-dependent renal changes in rats with a reduced nephron number. Hypertension 51: 1184-1189, 2008.
41. Sandgaard NC, Andersen JL, Bie P. Hormonal regulation of renal sodium and water excretion during normotensive sodium loading in conscious dogs. Am J Physiol Regul Integr Comp Physiol 278: R11-R18, 2000. (Pubitemid 30182666)
42. Santos RA, Campagnole-Santos MJ, Andrade SP. Angiotensin-(1-7): an update. Regul Pept 91: 45-62, 2000.
43. Santos RA, Simoes Silva AC, Maric C, Silva DM, Machado RP, de B, I, Heringer-Walther S, Pinheiro SV, Lopes MT, Bader M, Mendes EP, Lemos VS, Campagnole-Santos MJ, Schultheiss HP, Speth R, Walther T. Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc Natl Acad Sci USA 100: 8258-8263, 2003.
44. Schnurr E, Lahme W, Kuppers H. Measurement of renal clearance of inulin and PAH in the steady state without urine collection. Clin Nephrol 13: 26-29, 1980. (Pubitemid 10139745)
45. Shaltout HA, Figueroa JP, Rose JC, Chappell MC, Averill DB, Diz DI. Deleterious cardiovascular effects of antenatal betamethasone exposure in young and adult sheep (Abstract). FASEB J 22: 1129.16, 2008.
46. Sinclair JC. Meta-analysis of randomized controlled trials of antenatal corticosteroid for the prevention of respiratory distress syndrome: discussion. Am J Obstet Gynecol 173: 335-344, 1995.
47. Singh RR, Moritz KM, Bertram JF, Cullen-McEwen LA. Effects of dexamethasone exposure on rat metanephric development: in vitro and in vivo studies. Am J Physiol Renal Physiol 293: F548-F554, 2007.
48. Smith J, Nakahara S, Westwood B, Figueroa J, Chappell M, Rose JC. Prenatal betamethasone exposure alters renin angiotensin system enzyme expression in adult male sheep (Abstract). Reprod Sci 15: 274A, 2008.
49. Sun Q, Dimopoulos G, Nguyen DN, Tu Z, Nagy N, Hoang AD, Rogiers P, De BD, Vincent JL. Low-dose vasopressin in the treatment of septic shock in sheep. Am J Respir Crit Care Med 168: 481-486, 2003. (Pubitemid 37046879)
50. Tucker BJ, Peterson OW, Ziegler MG, Blantz RC. Analysis of adrenergic effects of the anesthetics Inactin and alpha-chloralose. Am J Physiol Renal Fluid Electrolyte Physiol 243: F253-F259, 1982.
51. Vallon V, Heyne N, Richter K, Khosla MC, Fechter K. [7-D-ALA]- angiotensin 1-7 blocks renal actions of angiotensin 1-7 in the anesthetized rat. J Cardiovasc Pharmacol 32: 164-167, 1998. (Pubitemid 28304710)
52. Vehaskari VM. Developmental origins of adult hypertension: new insights into the role of the kidney. Pediatr Nephrol 22: 490-495, 2007.
53. Wintour EM, Moritz K, Johnson K, Ricardo S, Samuel CS, Dodic M. Reduced nephron number in adult sheep, hypertensive as a result of prenatal glucocorticoid treatment. J Physiol Lond 549: 929-935, 2003. (Pubitemid 36889780)
54. Wintour EM, Moritz KM, Johnson K, Ricardo S, Samuel CS, Dodic M. Reduced nephron number in adult sheep, hypertensive as a result of prenatal glucocorticoid treatment. J Physiol 549: 929-935, 2003. (Pubitemid 36889780)
55. Woods LL, Weeks DA. Prenatal programming of adult blood pressure: role of maternal corticosteroids. Am J Physiol Regul Integr Comp Physiol 289: R955-R962, 2005.
56. Woods LL. Maternal glucocorticoids and prenatal programming of hypertension. Am J Physiol Regul Integr Comp Physiol 291: R1069-R1075, 2006.
57. Woods LL, Rasch R. Perinatal ANG II programs adult blood pressure, glomerular number, and renal function in rats. Am J Physiol Regul Integr Comp Physiol 275: R1593-R1599, 1998. (Pubitemid 28539025)
58. Woods LL, Weeks DA, Rasch R. Programming of adult blood pressure by maternal protein restriction: role of nephrogenesis. Kidney Int 65: 1339-1348, 2004. (Pubitemid 38406972)