Cardiovascular responses to incremental and sustained submaximal exercise in heart transplant recipients

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 296, Issue 2, 2009, Pages

  Scott, Jessica M ^a   Esch, Ben T A ^a   Haykowsky, Mark J ^b   Warburton, Darren E R ^a   Toma, Mustafa ^b   Jelani, Anwar ^b   Taylor, Dylan ^b   Paterson, Ian ^b   Poppe, Delores ^b   Liang, Yuanyuan ^b   Thompson, Richard ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Cardiac allograft; Exercise capacity; Hemodynamics

Indexed keywords

OXYGEN;

ADULT; AEROBIC EXERCISE; ARTICLE; BODY SURFACE; CARDIOVASCULAR RESPONSE; CLINICAL ARTICLE; CONTROLLED STUDY; ECHOGRAPHY; ELASTICITY; HEART EJECTION FRACTION; HEART LEFT VENTRICLE CONTRACTION; HEART LEFT VENTRICLE RELAXATION; HEART OUTPUT; HEART PRELOAD; HEART RATE; HEART TRANSPLANTATION; HUMAN; HUMAN EXPERIMENT; MALE; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RECIPIENT; SYSTEMIC VASCULAR RESISTANCE; SYSTOLE; AGED; CASE CONTROL STUDY; EXERCISE TEST; EXERCISE TOLERANCE; FEMALE; HEART FAILURE; HEART STROKE VOLUME; HEMODYNAMICS; MIDDLE AGED; PATHOPHYSIOLOGY; TREATMENT OUTCOME; VASCULAR RESISTANCE; VASODILATATION;

ADULT; AGED; CARDIAC OUTPUT; CASE-CONTROL STUDIES; ELASTICITY; EXERCISE TEST; EXERCISE TOLERANCE; FEMALE; HEART FAILURE; HEART RATE; HEART TRANSPLANTATION; HEMODYNAMICS; HUMANS; MALE; MIDDLE AGED; OXYGEN CONSUMPTION; STROKE VOLUME; TREATMENT OUTCOME; VASCULAR RESISTANCE; VASODILATION;

EID: 61949099953     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01100.2008     Document Type: Article

References (50)

1. Arnoult F, Loiseau A, Aptecar E, Loisance D, Nitenberg A. Ventricu- loarterial coupling and left ventricular efficiency in heart transplant recipients. Transplantation 64: 617-626, 1997.
2. Bengel FM, Ueberfuhr P, Schiepel N, Nekolla SG, Reichart B, Schwaiger M. Effect of sympathetic reinnervation on cardiac performance after heart transplantation. N Engl J Med 345: 731-738, 2001.
3. Bengel FM, Ueberfuhr P, Ziegler SI, Nekolla S, Reichart B, Schwaiger M. Serial assessment of sympathetic reinnervation after orthotopic heart transplantation. A longitudinal study using PET and C-11 hydroxyephedrine. Circulation 99: 1866-1871, 1999.
4. Braith RW. Exercise training in patients with CHF and heart transplant recipients. Med Sci Sports Exerc 30: S367-S378, 1998.
5. Braith RW, Plunkett MB, Mills RM Jr. Cardiac output responses during exercise in volume-expanded heart transplant recipients. Am J Cardiol 81: 1152-1156, 1998.
6. Braith RW, Wood CE, Limacher MC, Pollock ML, Lowenthal DT, Phillips MI, Staples ED. Abnormal neuroendocrine responses during exercise in heart transplant recipients. Circulation 86: 1453-1463, 1992.
7. Brubaker PH, Berry MJ, Brozena SC, Morley DL, Walter JD, Paolone AM, Bove AA. Relationship of lactate and ventilatory thresholds in cardiac transplant patients. Med Sci Sports Exerc 25: 191-196, 1993.
8. Burke MN, McGinn AL, Homans DC, Christensen BV, Kubo SH, Wilson RF. Evidence for functional sympathetic reinnervation of left ventricle and coronary arteries after orthotopic cardiac transplantation in humans. Circulation 91: 72-78, 1995.
9. Cerretelli P, Grassi B, Colombini A, Caru B, Marconi C. Gas exchange and metabolic transients in heart transplant recipients. Respir Physiol 74: 355-371, 1988.
10. Chantler PD, Lakatta EG, Najjar SS. Arterial-ventricular coupling: mechanistic insights into cardiovascular performance at rest and during exercise. J Appl Physiol 105: 1342-1351, 2008.
11. Coudray N, Beregi JP, Lecarpentier Y, Chemla D. Effects of isoproterenol on myocardial relaxation rate: influence of the level of load. Am J Physiol Heart Circ Physiol 265: H1645-H1653, 1993.
12. De Marco T, Dae M, Yuen-Green MS, Kumar S, Sudhir K, Keith F, Amidon TM, Rifkin C, Klinski C, Lau D, et al. Iodine-123 metaiodobenzylguanidine scintigraphic assessment of the transplanted human heart: evidence for late reinnervation. J Am Coll Cardiol 25: 927-931, 1995.
13. DuBois D, DuBois E. A formula to estimate the approximate surface area if height and weight be known. Arch Intern Med 17: 863-871, 1916.
14. Ferretti G, Marconi C, Achilli G, Caspani E, Fiocchi R, Mamprin F, Gamba A, Ferrazzi P, Cerretelli P. The heart rate response to exercise and circulating catecholamines in heart transplant recipients. Pflügers Arch 443: 370-376, 2002.
15. Hausdorf G, Banner NR, Mitchell A, Khaghani A, Martin M, Yacoub M. Diastolic function after cardiac and heart-lung transplantation. Br Heart J 62: 123-132, 1989.
16. O2peak and left ventricular systolic function in recent cardiac transplant recipients. Am J Cardiol 95: 1002-1004, 2005.
17. Higginbotham MB, Morris KG, Coleman RE, Cobb FR. Sex-related differences in the normal cardiac response to upright exercise. Circulation 70: 357-366, 1984.
18. Hosenpud JD, Morton MJ, Wilson RA, Pantely GA, Norman DJ, Cobanoglu MA, Starr A. Abnormal exercise hemodynamics in cardiac allograft recipients 1 year after cardiac transplantation. Relation to preload reserve. Circulation 80: 525-532, 1989.
19. Jendzjowsky NG, Tomczak CR, Lawrance R, Taylor DA, Tymchak WJ, Riess KJ, Warburton DE, Haykowsky MJ. Impaired pulmonary oxygen uptake kinetics and reduced peak aerobic power during small muscle mass exercise in heart transplant recipients. J Appl Physiol 103: 1722-1727, 2007.
20. Kao AC, Van Trigt P, 3rd Shaeffer-McCall GS, Shaw JP, Kuzil BB, Page RD, Higginbotham MB. Allograft diastolic dysfunction and chro- notropic incompetence limit cardiac output response to exercise two to six years after heart transplantation. J Heart Lung Transplant 14: 11-22, 1995.
21. Kao AC, Van Trigt P, 3rd Shaeffer-McCall GS, Shaw JP, Kuzil BB, Page RD, Higginbotham MB. Central and peripheral limitations to upright exercise in untrained cardiac transplant recipients. Circulation 89: 2605-2615, 1994.
22. Kavanagh T. Exercise rehabilitation in cardiac transplantation patients: a comprehensive review. Eura Medicophys 41: 67-74, 2005.
23. Kavanagh T, Yacoub MH, Mertens DJ, Kennedy J, Campbell RB, Sawyer P. Cardiorespiratory responses to exercise training after orthotopic cardiac transplantation. Circulation 77: 162-171, 1988.
24. Kaye DM, Esler M, Kingwell B, McPherson G, Esmore D, Jennings G. Functional and neurochemical evidence for partial cardiac sympathetic reinnervation after cardiac transplantation in humans. Circulation 88: 1110-1118, 1993.
25. Kelly RP, Ting CT, Yang TM, Liu CP, Maughan WL, Chang MS, Kass DA. Effective arterial elastance as index of arterial vascular load in humans. Circulation 86: 513-521, 1992.
26. Kociolek LK, Bierig SM, Herrmann SC, Labovitz AJ. Efficacy of atropine as a chronotropic agent in heart transplant patients undergoing dobutamine stress echocardiography. Echocardiography 23: 383-387, 2006.
27. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Picard MH, Roman MJ, Seward J, Shanewise JS,Solomon SD, Spencer KT, Sutton MS, Stewart WJ. Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 18: 1440-1463, 2005.
28. Lew WY, Rasmussen CM. Influence of nonuniformity on rate of left ventricular pressure fall in the dog. Am J Physiol Heart Circ Physiol 256: H222-H232, 1989.
29. Limas CJ, Olivari MT, Benditt DG, Almquist A. Altered calcium uptake by the sarcoplasmic reticulum following cardiac transplantation in humans. Can J Cardiol 3: 215-219, 1987.
30. Little WC, Cheng CP. Effect of exercise on left ventricular-arterial coupling assessed in the pressure-volume plane. Am J Physiol Heart Circ Physiol 264: H1629-H1633, 1993.
31. Little WC, Cheng CP. Left ventricular-arterial coupling in conscious dogs. Am J Physiol Heart Circ Physiol 261: H70-H76, 1991.
32. Mehra MR, Milani RV, Richie MB, Uber PA, Park MH, Ventura HO, Scott RL, Lavie CJ. Ventricular-vascular uncoupling increases expression of B-type natriuretic peptide in heart transplantation. Transplant Proc 36: 3149-3151, 2004.
33. Milani RV, Mehra MR, Lavie CJ, Ventura HO. Comparison of cardiac and peripheral arterial stiffening and ventriculovascular uncoupling in patients with uncomplicated hypertension versus patients with hypertension after heart transplantation. Am J Cardiol 98: 789-792, 2006.
34. Mohanty PK, Thames MD, Capehart JR, Kawaguchi A, Ballon B, Lower RR. Afferent reinnervation of the autotransplanted heart in dogs. J Am Coll Cardiol 7: 414-418, 1986.
35. Najjar SS, Schulman SP, Gerstenblith G, Fleg JL, Kass DA, O'Connor F, Becker LC, Lakatta EG. Age and gender affect ventricularvascular coupling during aerobic exercise. J Am Coll Cardiol 44: 611-617, 2004.
36. Palatini P, Frigo G, Visentin P, Mario L, Mormino P, Pessina AC. Left ventricular contractile performance in the early stage of hypertension in humans. Eur J Appl Physiol 85: 118-124, 2001.
37. Paulus WJ, Bronzwaer JG, Felice H, Kishan N, Wellens F. Deficient acceleration of left ventricular relaxation during exercise after heart transplantation. Circulation 86: 1175-1185, 1992.
38. Pokan R, Von Duvillard SP, Ludwig J, Rohrer A, Hofmann P, Wonisch M, Smekal G, Schmid P, Pacher R, Bachl N. Effect of high-volume and -intensity endurance training in heart transplant recipients. Med Sci Sports Exerc 36: 2011-2016, 2004.
39. Scherrer U, Vissing SF, Morgan BJ, Rollins JA, Tindall RS, Ring S, Hanson P, Mohanty PK, Victor RG. Cyclosporine-induced sympathetic activation and hypertension after heart transplantation. N Engl J Med 323: 693-699, 1990.
40. Stark RP, McGinn AL, Wilson RF. Chest pain in cardiac-transplant recipients. Evidence of sensory reinnervation after cardiac transplantation. N Engl J Med 324: 1791-1794, 1991.
41. Stickland MK, Welsh RC, Petersen SR, Tyberg JV, Anderson WD, Jones RL, Taylor DA, Bouffard M, Haykowsky MJ. Does fitness level modulate the cardiovascular hemodynamic response to exercise? J Appl Physiol 100: 1895-1901, 2006.
42. Studeli R, Jung S, Mohacsi P, Perruchoud S, Castiglioni P, Wenaweser P, Heimbeck G, Feller M, Hullin R. Diastolic dysfunction in human cardiac allografts is related with reduced SERCA2a gene expression. Am J Transplant 6: 775-782, 2006.
43. Sunagawa K, Maughan WL, Burkhoff D, Sagawa K. Left ventricular interaction with arterial load studied in isolated canine ventricle. Am J Physiol Heart Circ Physiol 245: H773-H780, 1983.
44. Tallaj JA, Kirklin JK, Brown RN, Rayburn BK, Bourge RC, Benza RL, Pinderski L, Pamboukian S, McGiffin DC, Naftel DC. Post-heart transplant diastolic dysfunction is a risk factor for mortality. J Am Coll Cardiol 50: 1064-1069, 2007.
45. Taylor DO, Edwards LB, Boucek MM, Trulock EP, Aurora P, Christie J, Dobbels F, Rahmel AO, Keck BM, Hertz MI. Registry of the International Society for Heart and Lung Transplantation: Twenty- Fourth Official Adult Heart Transplant Report-2007. J Heart Lung Transplant 26: 769 -781, 2007.
46. Teichholz LE, Kreulen T, Herman MV, Gorlin R. Problems in echocardiographic volume determinations: echocardiographic-angiographic correlations in the presence of absence of asynergy. Am J Cardiol 37: 7-11, 1976.
47. Tyni-Lenne R, Dencker K, Gordon A, Jansson E, Sylven C. Comprehensive local muscle training increases aerobic working capacity and quality of life and decreases neurohormonal activation in patients with chronic heart failure. Eur J Heart Fail 3: 47-52, 2001.
48. Uberfuhr P, Ziegler S, Schwaiblmair M, Reichart B, Schwaiger M. Incomplete sympathetic reinnervation of the orthotopically transplanted human heart: observation up to 13 years after heart transplantation. Eur J Cardiothorac Surg 17: 161-168, 2000.
49. Wasserman K. Determinants and detection of anaerobic threshold and consequences of exercise above it. Circulation 76: VI29 -VI39, 1987.
50. Wilson RF, Johnson TH, Haidet GC, Kubo SH, Mianuelli M. Sympathetic reinnervation of the sinus node and exercise hemodynamics after cardiac transplantation. Circulation 101: 2727-2733, 2000.