Efficacy of atropine as a chronotropic agent in heart transplant patients undergoing dobutamine stress echocardiography

Echocardiography

Volumn 23, Issue 5, 2006, Pages 383-387

  Kociolek, Larry K ^a   Bierig, S Michelle ^a,b   Herrmann, Steven C ^a   Labovitz, Arthur J ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SAINT LOUIS UNIVERSITY   (United States)

Author keywords

Atropine; Dobutamine; Dobutamine stress echocardiography; Echocardiography; Heart transplantation; Reinnervation

Indexed keywords

ATROPINE; DOBUTAMINE;

ADULT; AGED; ARTICLE; BLOOD PRESSURE MONITORING; CHOLINERGIC STIMULATION; CHRONOTROPISM; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; HEART RATE; HEART TRANSPLANTATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REINNERVATION; RETROSPECTIVE STUDY; STRESS ECHOCARDIOGRAPHY;

ADULT; AGED; ANALYSIS OF VARIANCE; ANTI-ARRHYTHMIA AGENTS; ATROPINE; CARDIOTONIC AGENTS; DOBUTAMINE; ECHOCARDIOGRAPHY, STRESS; FEMALE; HEART DISEASES; HEART RATE; HEART TRANSPLANTATION; HUMANS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; RESEARCH DESIGN; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 33745353875     PISSN: 07422822     EISSN: 15408175     Source Type: Journal    
DOI: 10.1111/j.1540-8175.2006.00223.x     Document Type: Article

References (24)

1. Toledo E, Pinhas I, Aravot D, et al : Functional restitution of cardiac control in heart transplant patients. Am J Physiol Regul Integr Comp Physiol 2002 282 ( 3 R900 R908.
2. Bengel FM, Ueberfuhr P, Ziegler SI, et al : Serial assessment of sympathetic reinnervation after orthotopic heart transplantation. A longitudinal study using PET and C-11 hydroxyephedrine. Circulation 1999 99 ( 14 1866 1871.
3. Estorch M, Camprecios M, Flotats A, et al : Sympathetic reinnervation of cardiac allografts evaluated by 123I-MIBG imaging. J Nucl Med 1999 40 ( 6 911 916.
4. Halpert I, Goldberg AD, Levine AB, et al : Reinnervation of the transplanted human heart as evidenced from heart rate variability studies. Am J Cardiol 1996 77 ( 2 180 183.
5. Raczak G, La Rovere MT, Mortara A, et al : Arterial baroreflex modulation of heart rate in patients early after heart transplantation: Lack of parasympathetic reinnervation. J Heart Lung Transplant 1999 18 ( 5 399 406.
6. Arrowood JA, Minisi AJ, Goudreau E, et al : Absence of parasympathetic control of heart rate after human orthotopic cardiac transplantation. Circulation 1997 96 ( 10 3492 3498.
7. Uberfuhr P, Frey AW, Fuchs A, et al : Signs of vagal reinnervation 4 years after heart transplantation in spectra of heart rate variability. Eur J Cardiothorac Surg 1997 12 ( 6 907 912.
8. Brunner-La Rocca HP, Weilenmann D, Bracht C, et al : Relative frequency of functional sympathetic and parasympathetic reinnervation after heart transplantation. J Heart Lung Transplant 1998 17 ( 7 725 728.
9. Uberfuhr P, Frey AW, Reichart B : Vagal reinnervation in the long term after orthotopic heart transplantation. J Heart Lung Transplant 2000 19 ( 10 946 950.
10. Wesche J, Orning O, Eriksen M, et al : Electrophysiological evidence of reinnervation of the transplanted human heart. Cardiology 1998 89 ( 1 73 75.
11. Smith ML, Ellenbogen KA, Eckberg DL, et al : Subnormal parasympathetic activity after cardiac transplantation. Am J Cardiol 1990 66 ( 17 1243 1246.
12. Bengel FM, Ueberfuhr P, Hesse T, et al : Clinical determinants of ventricular sympathetic reinnervation after orthotopic heart transplantation. Circulation 2002 106 ( 7 831 835.
13. Bernardi L, Valenti C, Wdowczyck-Szulc J, et al : Influence of type of surgery on the occurrence of parasympathetic reinnervation after cardiac transplantation. Circulation 1998 97 ( 14 1368 1374.
14. Hoffmann R, Lethen H, Kuhl H, et al : Extent and severity of test positivity during dobutamine stress echocardiography. Influence on the predictive value for coronary artery disease. Eur Heart J 1999 20 ( 20 1485 1492.
15. McNeill AJ, Fioretti PM, el-Said SM, et al : Enhanced sensitivity for detection of coronary artery disease by addition of atropine to dobutamine stress echocardiography. Am J Cardiol 1992 70 ( 1 41 46.
16. Fioretti PM, Poldermans D, Salustri A, et al : Atropine increases the accuracy of dobutamine stress echocardiography in patients taking beta-blockers. Eur Heart J 1994 15 ( 3 355 360.
17. Schroder K, Agrawal R, Voller H, et al : Factors influencing the diagnostic accuracy of dobutamine stress echocardiography. Int J Cardiovasc Imaging 1997 13 ( 6 493 498.
18. Akosah KO, McDaniel S, Hanrahan JS, et al : Dobutamine stress echocardiography early after heart transplantation predicts development of allograft coronary artery disease and outcome. J Am Coll Cardiol 1998 31 ( 7 1607 1614.
19. Armstrong W, Pellika P, Ryan T, et al : Stress echocardiography: Recommendations for performance and interpretation of stress echocardiography. J Am Soc Echocardiogr 1998 11 : 97 104.
20. Spes CH, Klauss V, Mudra H, et al : Diagnostic and prognostic value of serial dobutamine stress echocardiography for noninvasive assessment of cardiac allograft vasculopathy: A comparison with coronary angiography and intravascular ultrasound. Circulation 1999 100 ( 5 458 460.
21. Bacal F, Moreira L, Souza G, et al : Dobutamine stress echocardiography predicts cardiac events or death in asymptomatic patients long-term after heart transplantation: 4-year prospective evaluation. J Heart Lung Transplant 2004 23 ( 11 1238 1244.
22. Miller LW, Schlant RC, Kobashigawa J, et al : 24th Bethesda conference: Cardiac transplantation Task Force 5: Complications. J Am Coll Cardiol 1993 22 ( 1 41 54.
23. Flox A, Sanchez V, Delgado JF, et al : Is atropine infusion necessary to achieve the target heart rate in heart transplant patients during dobutamine stress echocardiography? Transplant Proc 2002 34 ( 8 3241 3242.
24. Leenen FH, Davies RA, Fourney A : Role of cardiac ß2-receptors in cardiac responses to exercise in cardiac transplant patients. Circulation 1995 91 ( 3 685 690.