Blockade of estrogen action upregulates estrogen receptor-α mRNA in the fetal brain

Neonatology

Volumn 96, Issue 2, 2009, Pages 115-119

  Schaub, Christine E ^a   Wood, Charles E ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Cerebellum; Faslodex; Fulvestrant; Hippocampus; Sheep fetus

Indexed keywords

AMPICILLIN; ESTROGEN; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FULVESTRANT; MESSENGER RNA; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN REGION; CATHETERIZATION; CEREBELLUM; CONTROLLED STUDY; DRUG INFUSION; ESTROGEN ACTIVITY; FEMALE; FETUS; HIPPOCAMPUS; NONHUMAN; NUCLEOTIDE SEQUENCE; POSTOPERATIVE INFECTION; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; SHEEP; SURGICAL TECHNIQUE; TWINS; UPREGULATION; WESTERN BLOTTING;

ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; EMBRYO, MAMMALIAN; ESTRADIOL; ESTROGEN ANTAGONISTS; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR MODULATORS; FETAL DEVELOPMENT; FETUS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; SHEEP;

OVIS; OVIS ARIES;

EID: 61849178683     PISSN: 16617800     EISSN: 16617819     Source Type: Journal    
DOI: 10.1159/000208793     Document Type: Article

References (27)

1. Gurpide E, Schwers J, Welch MT, Vande Wiele RL, Lieberman S: Fetal and maternal metabolism of estradiol during pregnancy. J Clin Endocrinol Metab 1966;26:1355-1365.
2. Wood CE: Estrogen/hypothalamus-pituitary-adrenal axis interactions in the fetus: the interplay between placenta and fetal brain. J Soc Gynecol Investig 2005;12:67-76.
3. Lehman MN, Ebling FJP, Moenter SM, Karsch FJ: Distribution of estrogen receptor-immunoreactive cells in the sheep brain. Endocrinology 1993;133:876-886.
4. Scott CJ, Rawson JA, Pereira AM, Clarke IJ: The distribution of estrogen receptors in the brainstem of female sheep. Neurosci Lett 1998;241:29-32. (Pubitemid 28079026)
5. Scott CJ, Tilbrook AJ, Simmons DM, Rawson JA, Chu S, Fuller PJ, Ing NH, Clarke IJ: The distribution of cells containing estrogen receptor-α (ER-α) and ER-β messenger ribonucleic acid in the preoptic area and hypothalamus of the sheep: comparison of males and females. Endocrinology 2000;141:2951-2962. (Pubitemid 32250460)
6. Friedman WJ, McEwen BS, Toran-Allerand CD, Gerlach JL: Perinatal development of hypothalamic and cortical estrogen receptors in mouse brain: methodological aspects. Brain Res 1983;313:19-27.
7. Schaub CE, Gersting JA, Keller-Wood M, Wood CE: Development of ER-α and ER-β expression in the developing ovine brain and pituitary. Gene Expr Patterns 2008;8:457-463.
8. Wood CE: Cerebral hypoperfusion increases estrogen receptor abundance in the ovine fetal brain and pituitary. Neuroendocrinology 2008;87:216-222.
9. Wood CE, Giroux D: Central nervous system prostaglandin endoperoxide synthase-1 and -2 responses to oestradiol and cerebral hypoperfusion in late-gestation fetal sheep. J Physiol 2003;549:573-581.
10. Schaub CE, Keller-Wood M, Wood CE: Blockade of estrogen receptors decreases CNS and pituitary prostaglandin synthase expression in fetal sheep. Neuroendocrinology 2008;87:121-128. (Pubitemid 351301282)
11. Rudolph AM, Heymann MA: The circulation of the fetus in utero: methods for studying the distribution of blood flow, cardiac output, and organ blood flow. Circ Res 1967;21:163-184.
12. Keller-Wood M, Powers MJ, Gersting JA, Ali N, Wood CE: Genomic analysis of neuroendocrine development of fetal brain-pituitary-adrenal axis in late gestation. Physiol Genomics 2006;24:218-224.
13. Byers MJ, Zangl A, Phernetton TM, Lopez G, Chen DB, Magness RR: Endothelial vasodilator production by ovine uterine and systemic arteries: ovarian steroid and pregnancy control of ER-alpha; and ER- levels. J Physiol 2005;565:85-99. (Pubitemid 40723693)
14. Wood CE, Cousins R, Zhang D, Keller-Wood M: Ontogeny of expression of organic anion transporters 1 and 3 in ovine fetal and neonatal kidney. Exp Biol Med (Maywood) 2005;230:668-673. (Pubitemid 41506862)
15. Al-Bader MD, Al-Sarraf HA: Housekeeping gene expression during fetal brain development in the rat-validation by semi-quantitative RT-PCR. Brain Res Dev Brain Res 2005;156:38-45.
16. -ΔΔCT method. Methods 2001;25:402-408.
17. Winer BJ: Statistical Principles in Experimental Design, ed 2. New York, McGraw-Hill, 1971.
18. Field A: Discovering Statistics Using SPSS, ed 2, London, Sage Publications, 2005.
19. Brown TJ, Scherz B, Hochberg RB, MacLusky NJ: Regulation of estrogen receptor concentrations in the rat brain: effects of sustained androgen and estrogen exposure. Neuroendocrinology 1996;63:53-60. (Pubitemid 26025222)
20. Simerly RB, Young BJ: Regulation of estrogen receptor messenger ribonucleic acid in rat hypothalamus by sex steroid hormones. Mol Endocrinol 1991;5:424-432.
21. Valley CC, Metivier R, Solodin NM, Fowler AM, Mashek MT, Hill L, Alarid ET: Differential regulation of estrogen-inducible proteolysis and transcription by the estrogen receptor α N terminus. Mol Cell Biol 2005;25:5417-5428. (Pubitemid 40861697)
22. Osborne CK, Wakeling A, Nicholson RI: Fulvestrant: an oestrogen receptor antagonist with a novel mechanism of action. Br J Cancer 2004;90(suppl 1):S2-S6. (Pubitemid 38482618)
23. Schreihofer DA, Stoler MH, Shupnik MA: Differential expression and regulation of estrogen receptors (ERs) in rat pituitary and cell lines: estrogen decreases ER-α protein and estrogen responsiveness. Endocrinology 2000;141:2174-2184.
24. Hatsumi T, Yamamuro Y: Downregulation of estrogen receptor gene expression by exogenous 17β-estradiol in the mammary glands of lactating mice. Exp Biol Med (Maywood) 2006;231:311-316. (Pubitemid 43334317)
25. Kos M, Denger S, Reid G, Gannon F: Upstream open reading frames regulate the translation of the multiple mRNA variants of the estrogen receptor α. J Biol Chem 2002;277:37131-37138.
26. Anderson ABM, Flint AP, Turnbull AC: Mechanism of activation of glucocorticoids in induction of ovine parturition: effect on placental steroid metabolism. J Endocr 1975;66:61-70.
27. Saoud CJ, Wood CE: Modulation of ovine fetal adrenocorticotropin secretion by androstenedione and 17β-estradiol. Am J Physiol 1997;272:R1128-R1134. (Pubitemid 27202569)