Synthesis of hydroxypyrone- and hydroxythiopyrone-based matrix metalloproteinase inhibitors: Developing a structure-activity relationship

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 7, 2009, Pages 1970-1976

  Yan, Yi Long ^a   Miller, Melissa T ^a   Cao, Yuchen ^a   Cohen, Seth M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Drug design; Inhibitors; Metalloproteinases; Pyrones; Zinc

Indexed keywords

GELATINASE A; HYDROXYPYRONE DERIVATIVE; HYDROXYTHIOPYRONE DERIVATIVE; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; PEPTIDOMIMETIC AGENT; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; STROMELYSIN; UNCLASSIFIED DRUG; ZINC;

ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; QUANTUM YIELD; STRUCTURE ACTIVITY RELATION;

CARRIER PROTEINS; DRUG DESIGN; MATRIX METALLOPROTEINASES; PROTEASE INHIBITORS; PYRONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 61849172493     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.02.044     Document Type: Article

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