Atrial proarrhythmia due to increased inward rectifier current (IK1) arising from KCNJ2 mutation - A simulation study

Progress in Biophysics and Molecular Biology

Volumn 98, Issue 2-3, 2008, Pages 186-197

  Kharche, Sanjay ^a   Garratt, Clifford J ^a   Boyett, Mark R ^a   Inada, Shin ^a   Holden, Arun V ^b   Hancox, Jules C ^c   Zhang, Henggui ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c School of Medical Sciences ^*  (United Kingdom)

Author keywords

Arrhythmia; Channelopathy; Fibrillation atrial; Gene mutation; IK1; Inward rectifier; Ion channels; Potassium channel; Sudden death

Indexed keywords

INWARDLY RECTIFYING POTASSIUM CHANNEL; KCNJ2 PROTEIN, HUMAN;

ACTION POTENTIAL; ALGORITHM; ANIMAL; ARTICLE; BIOLOGICAL MODEL; CELL STRAIN COS1; CERCOPITHECUS; GENETICS; HEART ATRIUM; HEART ATRIUM FIBRILLATION; HEART MUSCLE CELL; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MUTATION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; THREE DIMENSIONAL IMAGING;

ACTION POTENTIALS; ALGORITHMS; ANIMALS; ATRIAL FIBRILLATION; CERCOPITHECUS AETHIOPS; COS CELLS; HEART ATRIA; HETEROZYGOTE; HOMOZYGOTE; HUMANS; IMAGING, THREE-DIMENSIONAL; MODELS, CARDIOVASCULAR; MUTATION; MYOCYTES, CARDIAC; POTASSIUM CHANNELS, INWARDLY RECTIFYING;

EID: 61849171169     PISSN: 00796107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbiomolbio.2008.10.010     Document Type: Article

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