Innovative combination strategy to enhance effect and diminish adverse effects of glucocorticoids: Another promise?

Arthritis Research and Therapy

Volumn 11, Issue 1, 2009, Pages

  Jacobs, Johannes W G ^a   Bijlsma, Johannes W J ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DEFLAZACORT; DEXAMETHASONE; DIPYRIDAMOLE; GELATINASE B; GLUCOCORTICOID; PREDNISOLONE; RANTES; ANTIRHEUMATIC AGENT; IMMUNOSUPPRESSIVE AGENT; PHOSPHODIESTERASE INHIBITOR;

ANTIINFLAMMATORY ACTIVITY; CORTICOSTEROID THERAPY; DOSAGE SCHEDULE COMPARISON; DOSE RESPONSE; DRUG EFFICACY; DRUG MEGADOSE; DRUG POTENTIATION; DRUG RELEASE; DRUG TARGETING; EDITORIAL; ENZYME INHIBITION; EVENING DOSAGE; LOW DRUG DOSE; MORNING DOSAGE; MORNING STIFFNESS; MOUSE; NONHUMAN; RAT; RHEUMATOID ARTHRITIS; TABLET; ANIMAL; DRUG COMBINATION; NOTE;

ANIMALS; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; DIPYRIDAMOLE; DRUG THERAPY, COMBINATION; GLUCOCORTICOIDS; IMMUNOSUPPRESSIVE AGENTS; PHOSPHODIESTERASE INHIBITORS; PREDNISOLONE;

EID: 61849163849     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2615     Document Type: Editorial

References (11)

1. CombinatoRx homepage http://www.combinatorx.com
2. Zimmermann GR Avery W Finelli AL Farwell M Fraser CC Borisy AA Selective amplification of glucocorticoid anti-inflammatory activity through synergistic multi-target action of a combination drug Arthritis Res Ther 2009, 11:R12. 10.1186/ar2602 19171052
3. Kirwan JR Bijlsma JW Boers M Shea BJ Effects of glucocorticoids on radiological progression in rheumatoid arthritis Cochrane Database Syst Rev 2007, 1:CD006356. 17253590
4. Da Silva JA Jacobs JW Kirwan JR Boers M Saag KG Inês LB de Koning EJ Buttgereit F Cutolo M Capell H Rau R Bijlsma JW Safety of low dose glucocorticoid treatment in rheumatoid arthritis: Published evidence and prospective trial data Ann Rheum Dis 2006, 65:285-293. 10.1136/ ard.2005.038638 16107513 1798053
5. Hoes JN Jacobs JW Boers M Boumpas D Buttgereit F Caeyers N Choy EH Cutolo M Da Silva JA Esselens G Guillevin L Haf-strom I Kirwan JR Rovensky J Russell A Saag KG Svensson B Westhovens R Zeidler H Bijlsma JW EULAR evidence-based recommendations on the management of systemic glucocorticoid therapy in rheumatic diseases Ann Rheum Dis 2007, 66:1560-1567. 10.1136/ard.2007.072157 17660219
6. Krogsgaard MR Thamsborg G Lund B Changes in bone mass during low dose corticosteroid treatment in patients with polymyalgia rheumatica: A double blind, prospective comparison between prednisolone and deflazacort Ann Rheum Dis 1996, 55:143-146. 1010111 8712867 10.1136/ ard.55.2.143
7. Buttgereit F Doering G Schaeffler A Witte S Sierakowski S Gromnica-Ihle E Jeka S Krueger K Szechinski J Alten R Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): A double-blind, randomised controlled trial Lancet 2008, 371:205-214. 10.1016/S0140-6736(08)60132-4 18207016
8. Bijlsma JW Jacobs JW Glucocorticoid chronotherapy in rheumatoid arthritis Lancet 2008, 371:183-184. 10.1016/S0140-6736(08)60114-2 18207003
9. Rhen T Cidlowski JA Antiinflammatory action of glucocorticoids - new mechanisms for old drugs N Engl J Med 2005, 353:1711-1723. 10.1056/ NEJMra050541 16236742
10. Koning GA Schiffelers RM Wauben MH Kok RJ Mastrobattista E Molema G ten Hagen TL Storm G Targeting of angiogenic endothelial cells at sites of inflammation by dexamethasone phosphate-containing RGD peptide liposomes inhibits experimental arthritis Arthritis Rheum 2006, 54:1198-1208. 10.1002/art.21719 16575845
11. Bijlsma JW Saag KG Buttgereit F da Silva JA Developments in glucocorticoid therapy Rheum Dis Clin North Am 2005, 31:1-17. 10.1016/ j.rdc.2004.10.003 15639052