Synthesis of actin-depolymerizing compounds

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 7, 2009, Pages 1896-1898

  Kitamura, Kazuhiro ^a   Teruya, Toshiaki ^a   Kuroda, Takeshi ^b   Kigoshi, Hideo ^b   Suenaga, Kiyotake ^a  

^a KEIO UNIVERSITY   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Actin; Actin depolymerizing activity; Aplyronine A; Cytotoxicity; Synthesis

Indexed keywords

ACTIN DEPOLYMERIZING FACTOR; APLYRONINE A; F ACTIN;

ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORESCENCE; HUMAN; HUMAN CELL; OLEFINATION; REACTION ANALYSIS;

ACTINS; CELL LINE; HELA CELLS; HUMANS; LACTONES; MACROLIDES; SERINE;

EID: 61849111296     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.02.068     Document Type: Article

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22. 3) δ 8.28 [8.08] (s, 1H), 7.27-7.14 (m, 5H), 6.48 (d, J = 14.0 Hz, 1H), 5.65 (m, 1H), 5.37 (m, 1H), 5.37 (m, 1H), 4.98 (m, 1H), 4.83 (dd, J = 2.8, 9.9 Hz, 1H), 3.23 (q, J = 7.0 Hz, 1H), 3.03 [3.07] (s, 3H), 2.59 (t, J = 7.6 Hz, 2H), 2.59 (m, 1H), 2.37 (s, 6H), 2.09 (s, 3H), 1.81 (m, 1H), 1.60 (m, 2H), 1.40 (m, 2H), 1.30 (d, J = 6.8 Hz, 3H), 1.03 (d, J = 6.4 Hz, 3H), 0.95 (d, J = 6.8 Hz, 3H). The minor counterparts of doubled signals in the ratio of 2:1 are in brackets. The minor counterpart of the signal of 6.48 ppm was overlapped with those of 7.27-7.14 ppm.
23. 50 values of aplyronine A in the presence (5 mg/mL) and absence of analog 6 were 0.2 ng/mL and 0.2 ng/mL, respectively.