Short-term oral oestrogen therapy dissociates the growth hormone/insulin-like growth factor-I axis without altering energy metabolism in premenopausal women

Growth Hormone and IGF Research

Volumn 19, Issue 2, 2009, Pages 162-167

  Huang, Denise S ^a   O'Sullivan, Anthony J ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Body composition; Energy metabolism; Growth hormone; Insulin like growth factor I; Oestradiol

Indexed keywords

ESTRADIOL VALERATE; ESTROGEN; GROWTH HORMONE; PLACEBO; SOMATOMEDIN C;

ARTICLE; BLOOD SAMPLING; BODY COMPOSITION; CALORIMETRY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET RESTRICTION; DOUBLE BLIND PROCEDURE; ENERGY EXPENDITURE; ENERGY METABOLISM; FATTY ACID OXIDATION; FEMALE; GROWTH HORMONE BLOOD LEVEL; HUMAN; IMPEDANCE; PREMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

BODY COMPOSITION; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENERGY METABOLISM; ESTRADIOL; ESTROGENS; FATTY ACIDS; FEMALE; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; OXIDATION-REDUCTION; PREMENOPAUSE; YOUNG ADULT;

EID: 61849100896     PISSN: 10966374     EISSN: 15322238     Source Type: Journal    
DOI: 10.1016/j.ghir.2008.08.009     Document Type: Article

References (28)

1. Weissberger A.J., Ho K.K.Y., and Lazarus L. Contrasting effects of oral and transdermal routes of estrogen replacement therapy on 24-hour growth hormone (GH) secretion, insulin-like growth factor I and GH-binding protein in postmenopausal women. J. Clin. Endocrinol. Metab. 72 (1991) 374-381
2. Lissett C.A., and Shalet S.M. The impact of dose and route of estrogen administration on the somatotropic axis in normal women. J. Clin. Endocrinol. Metab. 88 (2003) 4668-4672
3. Leung K.C., Johannsson G., Leong G.M., and Ho K.K.Y. Estrogen regulation of growth hormone action. Endocrinol. Rev. 25 (2004) 693-721
4. Kelly J.J., Rajkovic I.A., O'Sullivan A.J., Sernia C., and Ho K.K.Y. Effects of different oral oestrogen formulations on insulin-like growth factor-I, growth hormone and growth hormone binding protein in post-menopausal women. Clin. Endocrinol. 39 (1993) 561-567
5. Chapman I.M., Hartman M.L., Pieper K.S., et al. Recovery of growth hormone release from suppression by exogenous insulin-like growth factor I (IGF-I): evidence for a suppressive action of free rather than bound IGF-I. J. Clin. Endocrinol. Metab. 83 (1998) 2836-2842
6. Murphy L.J., and Freisen H.G. Differential effects of estrogen and growth hormone on uterine and hepatic insulin-like growth factor-I expression in the ovariectomised hypophysectomized rat. Endocrinology 122 (1988) 325-332
7. Meinhardt U.J., and Ho K.K.Y. Modulation of growth hormone action by sex steroids. Clin. Endocrinol. 65 (2006) 413-422
8. O'Sullivan A.J., Crampton L., Freund J., and Ho K.K.Y. The route of oestrogen replacement therapy confers divergent effects on substrate oxidation and body composition in postmenopausal women. J. Clin. Invest. 102 (1998) 1035-1040
9. Ley C.J., Lees B., and Stevenson J.C. Sex- and menopause associated changes in body-fat distribution. Am. J. Clin. Nutr. 55 (1992) 950-954
10. Lemieux S., Prud'homme D., Bouchard C., Tremblay A., and Despres J.P. Sex- and menopause-associated changes in body-fat distribution. Am. J. Clin. Nutr. 55 (1992) 950-954
11. Pichard C., Kyle U.G., Bracco D., Slosman D.O., Morabia A., and Schutz Y. Reference values of fat-free and fat masses by bioelectrical impedance analysis in 3393 healthy subjects. Nutrition 16 (2000) 245-254
12. Australian Bureau of Statistics and Commonwealth Department of Health and Aged Care: National Nutrition Survey: Nutrient Intakes and Physical Measurements, Australia 1995, Australian Bureau of Statistics (1998) Canberra.
13. Ogle G.D., Allen J.R., Humphries I.R., et al. Body-composition assessment by dual-energy X-ray absorptiometry in subjects aged 4-26 y. Am. J. Clin. Nutr. 61 (1995) 746-753
14. O'Sullivan A.J., Martin A., and Brown M.A. Efficient fat storage in premenopausal women and in early pregnancy: a role for oestrogen. J. Clin. Endocrinol. Metab. 86 (2001) 4951-4956
15. Uranga A.P., Levine J., and Jensen M. Isotope tracer measures of meal fatty acid metabolism: reproducibility and effects of the menstrual cycle. Am. J. Physiol. 288 (2005) E547-E555
16. Rosenbaum M., and Leibel R.L. Role of gondal steroids in the sexual dimorphisms in body composition and circulating concentrations of leptin. J. Clin. Endocrinol. Metab. 84 (1999) 1784-1789
17. Gibney J., Johannsson G., Leung K.C., and Ho K.K.Y. Comparison of the metabolic effects of raloxifene and oral estrogen in postmenopausal and growth hormone-deficient women. J. Clin. Endocrinol. Metab. 90 (2005) 3897-3903
18. Nugent A.G., Leung K.C., Sullivan D., Reutens A.T., and Ho K.K.Y. Modulation by progestogens on hepatic endocrine function in postmenopausal women. Clin. Endocrinol. 59 (2003) 690-698
19. O'Sullivan A.J., Lawson J.A., Chan M., and Kelly J.J. Body composition and energy metabolism in chronic renal insufficiency. Am. J. Kidney Dis. 39 (2002) 369-375
20. O'Sullivan A.J., Kelly J.J., Hoffman D.M., Freund J., and Ho K.K.Y. Body composition and energy expenditure in acromegaly. J. Clin. Endocrinol. Metab. 78 (1994) 381-386
21. Balogh A., Kauf E., Vollanth R., Graser G., Klinger G., and Oettel M. Effects of two oral contraceptives on plasma levels of insulin-like growth factor I (IGF-I) and growth hormone (hGH). Contraception 62 (2000) 259-269
22. Eden Engstrom B., Burman P., Johannsson A.G., Wide L., and Karlsson F.A. Effects of short-term administration of growth hormone in healthy young men, women, and women taking oral contraceptives. J. Int. Med. 247 (2000) 570-578
23. Leung K.C., Doyle N., Ballesteros M., et al. Estrogen inhibits GH signaling by suppressing GH-induced phosphorylation, an effect mediated by SOCS-2. Proc. Natl. Acad. Sci. 100 (2003) 1016-1021
24. Shah N., Evans W.S., and Veldhuis J.D. Actions of estrogen on pulsatile, nyctohemeral, and entropic modes of growth hormone secretion. Am. J. Physiol. 276 (1999) R1351-R1358
25. Bray M.J., Vick T.M., Sha N., et al. Short-term estradiol replacement in postmenopausal women selectively mutes somatostatin's dose-dependent inhibition of fasting growth hormone secretion. J. Clin. Endocrinol. Metab. 86 (2001) 3143-3149
26. Ansbacher R., and Arbor A. The pharmacokinetics and efficacy of different estrogens are not equivalent. Am. J. Obstet. Gynecol. 184 (2001) 255-263
27. Gower B.A., Nagy T.R., Blaylock M.L., Wang C., and Nyman L L. Estradiol may limit lipid oxidation via CPT-1 expression and hormonal mechanisms. Obes. Res. 10 (2002) 167-172
28. Gupta S. Weight gain on the combined pill - is it real?. Hum. Reprod. Update 6 (2000) 427-431