Low doses of nicotine-induced fetal cardiovascular responses, hypoxia, and brain cellular activation in ovine fetuses

NeuroToxicology

Volumn 30, Issue 2, 2009, Pages 290-297

  Guan, Junchang ^a,b   Mao, Caiping ^a   Xu, Feicao ^a   Zhu, Liyan ^a   Liu, Yujuan ^a   Geng, Chongsong ^a   Zhang, Lubo ^a,c   Xu, Zhice ^a,c  

^a MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^b BENGBU MEDICAL COLLEGE   (China)

^c LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Blood pressure; c Fos expression; Neurotoxin

Indexed keywords

ELECTROLYTE; LACTIC ACID; NICOTINE; PROTEIN C FOS; PROTEIN FOS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD GAS; BLOOD PRESSURE; BRAIN; CARDIOVASCULAR RESPONSE; CARDIOVASCULAR SYSTEM; CELL ACTIVATION; CONTROLLED STUDY; ELECTROLYTE BLOOD LEVEL; ELECTROLYTE URINE LEVEL; EWE; FETUS; FETUS BLOOD; HEART RATE; HYPOXIA; LACTATE BLOOD LEVEL; LOW DRUG DOSE; MALE; MATERNAL BLOOD; NONHUMAN; OXYGEN SATURATION; OXYGEN TENSION; PREGNANCY; PRIORITY JOURNAL; SERUM OSMOLALITY; SUBFORNICAL ORGAN; THALAMUS MIDLINE NUCLEUS; ANIMAL; CHEMICALLY INDUCED; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECTS; EMBRYOLOGY; FEMALE; FETOMATERNAL TRANSFUSION; FETUS HEART RATE; FETUS HYPOXIA; METABOLISM; PHYSIOLOGY; SHEEP; TOXICITY;

ANIMALS; BRAIN; CARDIOVASCULAR SYSTEM; FEMALE; FETAL BLOOD; FETAL HYPOXIA; FETUS; HEART RATE, FETAL; MATERNAL-FETAL EXCHANGE; NICOTINE; PREGNANCY; SHEEP;

OVIS;

EID: 61849084695     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2008.12.013     Document Type: Article

References (31)

1. Abreu-Villaca Y., Seidler F.J., Tate C.A., and Slotkin T.A. Nicotine is a neurotoxin in the adolescent brain: critical periods, patterns of exposure, regional selectivity, and dose thresholds for macromolecular alterations. Brain Res 979 (2003) 114-128
2. Ankarberg E., Fredriksson A., and Eriksson P. Neurobehavioural defects in adult mice neonatally exposed to nicotine: changes in nicotine-induced behavior and maze learning performance. Behav Brain Res 123 (2001) 185-192
3. Barton C.H., Ni Z., and Vaziri N.D. Blood pressure response to hypoxia: role of nitric oxide synthase. Am J Hypertens 16 12 (2001) 1043-1048
4. Benowitz N.L., Kuyt F., and Jacob III P. Influence of nicotine on cardiovascular and hormonal effects of cigarette smoking. Clin Pharmacol Ther 36 (1984) 74-81
5. Calbet J.A. Chronic hypoxia increases blood pressure and noradrenaline spillover in healthy humans. J Physiol 551 (2003) 379-386
6. Coleman T., Britton J., and Thornton J. Nicotine replacement therapy in pregnancy. BMJ 328 (2004) 965-966
7. Cryer P.E., Haymond M.W., Santiago J.V., and Shah S.D. Norepinephrine and epinephrine release and adrenergic mediation of smoking-associated hemodynamic and metabolic events. N Engl J Med 295 (1976) 573-577
8. Dempsey D.A., and Benowitz N.L. Risks and benefits of nicotine to aid smoking cessation in pregnancy. Drug Saf 24 4 (2001) 277-322
9. Eisenblätter T., Hüwel S., and Galla H.J. Characterisation of the brain multidrug resistance protein (BMDP/ABCG2/BCRP) expressed at the blood-brain barrier. Brain Res 971 2 (2003) 221-231
10. Fernandes K.B., Tavares R.F., Pelosi G.G., and Corrêa F.M. The paraventricular nucleus of hypothalamus mediates the pressor response to noradrenergic stimulation of the medial prefrontal cortex in unanesthetized rats. Neurosci Lett 426 2 (2007) 101-105
11. Fletcher E.C., Orolinova N., and Bader M. Blood pressure response to chronic episodic hypoxia: the renin-angiotensin system. J Appl Physiol 92 2 (2002) 627-633
12. Kirschbaum T.H., Dilts Jr. P.V., and Brinkman III C.R. Some acute effects of smoking in sheep and their fetuses. Obstet Gynecol 35 (1970) 527-536
13. Lindblad A., Marsal K., and Andersson K.E. Effect of nicotine on human fetal blood flow. Obstet Gynecol 72 (1988) 371-382
14. Lv J., Mao C., Zhu L., Zhang H., Pengpeng H., Xu F., Liu Y., Zhang L., and Xu Z. Effects of prenatal nicotine on expression of nicotine receptor subunits in the fetal brain. Neurotoxicology 29 4 (2008) 722-726
15. Mao C., Yuan X., Cui Y., Li H., Lv J., Feng X., Liu Y., Chen L., and Xu Z. Prenatal exposure to nicotine with associated in utero hypoxia decreased fetal brain muscarinic mRNA in the rat. Brain Res 1189 (2008) 43-50
16. Manning F., Walker D., and Feyerabend C. The effect of nicotine on fetal breathing movements in conscious pregnant ewes. Obstet Gynecol 52 (1978) 563-568
17. Najem B., Houssière A., Pathak A., Janssen C., Lemogoum D., Xhaët O., Cuylits N., and van de Borne P. Acute cardiovascular and sympathetic effects of nicotine replacement therapy. Hypertension 47 (2006) 1162-1167
18. Neff R.A., Humphrey J., Mihalevich M., and Mendelowitz D. Nicotine enhances presynaptic and postsynaptic glutamatergic neurotransmission to activate cardiac parasympathetic neurons. Circ Res 83 12 (1998) 1241-1247
19. Ness J.M., Harvey C.R., Washington J.D., Roth K.A., Carroll S.L., and Zhang J. Differential activation of c-fos and caspase-3 in hippocampal neuron subpopulations following neonatal hypoxia-ischemia. J Neurosci Res 86 5 (2008) 1115-1124
20. Nielsen A., Hannibal C.G., Lindekilde B.E., Tolstrup J., Frederiksen K., Munk C., Bergholt T., Buss L., Ottesen B., Grønbaek M., and Kjaer S.K. Maternal smoking predicts the risk of spontaneous abortion. Acta Obstet Gynecol Scand 85 9 (2006) 1057-1065
21. Pollack H., Lantz P.M., and Frohna J.G. Maternal smoking and adverse birth outcomes among singletons and twins. Am J Public Health 90 (2000) 395-400
22. Rinaman L., Stricker E.M., Hoffman G.E., and Verbalis J.G. Central c-Fos expression in neonatal and adult rats after subcutaneous injection of hypertonic saline. Neuroscience 79 (1997) 1165-1175
23. Sagar S.M., Sharp F.R., and Curran T. Expression of c-Fos protein in brain: metabolic mapping at the cellular level. Science 240 (1988) 1328-1331
24. Salihu H.M., Aliyu M.H., Pierre-Louis B.J., and Alexander G.R. Levels of excess infant deaths attributable to maternal smoking during pregnancy in the United States. Matern Child Health J 7 (2003) 219-227
25. Seppä T., Salminen O., Moed M., and Ahtee L. Induction of Fos-immunostaining by nicotine and nicotinic receptor antagonists in rat brain. Neuropharmacology 41 (2001) 486-495
26. Shram M.J., Funk D., Li Z., and Lê A.D. Acute nicotine enhances c-fos mRNA expression differentially in reward-related substrates of adolescent and adult rat brain. Neurosci Lett 418 (2007) 286-291
27. Suzuki K., Horiguchi T., Comas-Urrutia A.C., Mueller-Heubach E., Morishima H.O., and Adamsons K. Pharmacologic effects of nicotine upon the fetus and mother in the rhesus monkey. Am J Obstet Gynecol 111 (1971) 1092-1101
28. Suzuki K., Horiguchi T., Comas-Urrutia A.C., Mueller-Heubach E., Morishima H.O., and Adamsons K. Placental transfer and distribution of nicotine in the pregnant rhesus monkey. Am J Obstet Gynecol 119 (1974) 253-262
29. Trauth J.A., Seidler F.J., McCook E.C., and Slotkin T.A. Persistent c-fos induction by nicotine in developing rat brain regions: interaction with hypoxia. Pediatr Res 45 1 (1999) 38-45
30. Westman E.C. Does smokeless tobacco cause hypertension?. South Med J 88 (1995) 716-720
31. Xu Z., Hu F., Shi L., Sun W., Wu J., Morrissey P., and Yao J. Angiotensin-induced vasopressin release and activation of hypothalamic neuron in pre-term fetuses. Peptides 26 2 (2005) 307-314