Clinical evaluation of the T-SPOT.TB test for patients with indeterminate results on the QuantiFERON TB-2G test

Internal Medicine

Volumn 48, Issue 3, 2009, Pages 137-142

  Kobashi, Yoshihiro ^a   Sugiu, Tadaaki ^a   Shimizu, Hiroki ^a   Ohue, Yoshihiro ^a   Mouri, Keiji ^a   Obase, Yasushi ^a   Miyashita, Naoyuki ^a   Oka, Mikio ^a  

^a KAWASAKI MEDICAL SCHOOL   (Japan)

Author keywords

Elderly patient; Hyponutritional condition; Indeterminate result; QuantiFERON TB 2G (QFT 2G) test; T SPOT.TB test

Indexed keywords

GAMMA INTERFERON; TUBERCULOSTATIC AGENT;

ADULT; AGED; ALBUMIN BLOOD LEVEL; ARTICLE; CLINICAL EVALUATION; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; FEMALE; HUMAN; IMMUNOASSAY; IMMUNOCOMPROMISED PATIENT; LABORATORY DIAGNOSIS; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MICROBIOLOGICAL EXAMINATION; PROTEIN BLOOD LEVEL; TUBERCULOSIS;

AGED; AGED, 80 AND OVER; COHORT STUDIES; FEMALE; HUMANS; INTERFERON-GAMMA; MALE; MIDDLE AGED; REAGENT KITS, DIAGNOSTIC; SENSITIVITY AND SPECIFICITY; TUBERCULIN TEST; TUBERCULOSIS;

EID: 61749087490     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.48.1432     Document Type: Article

References (20)

1. Brock I, Weldngh K, Lillebaek T, et al. Comparison of tuberculin skin test and new specific blood test in tuberculosis contacts. Am J Respir Crit Care Med 170: 65-69, 2004.
2. Mori T, Sakatani M, Yamagishi F, et al. Specific detection of tuberculosis infection: an interferon-γ- based assay using new antigens. Am J Respir Crit Care Med 170: 59-64, 2004.
3. Lavani A, Nagvenkar P, Udwadia Z, et al. Enumeration of T cells specific for RD1-encoded antigens suggests a high prevalence of latent Mycobacterium tuberculosis infection in healthy urban Indians. J Infect Dis 183: 469-477, 2001.
4. Richeldi L. An update on the diagnosis of tuberculosis infection. Am J Respir Crit Care Med 174: 736-742, 2006.
5. Diel R, Nienhaus A, Lange C, Meywald-Walter K, Forssbohm M, Schaberg T. Tuberculosis contact investigation with a new, specific blood test in a low-incidence population containing a high proportion of BCG-vaccinated persons. Respir Res 7: 77, 2006.
6. Lalvani A, Pathan AA, Durkan H, et al. Enhanced contact tracing and spatial tracking of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells. Lancet 357: 2017-2021, 2001.
7. Lee JY, Choi HJ, Park IN, et al. Comparison of two commercial interferon-γ assays for diagnosing Mycobacterium tuberculosis infection. Eur Respir J 28: 24-30, 2006.
8. Arend SM, Thijsen SF, Leyten EM, et al. Comparison of two interferon-γ assays and tuberculin skin test for tracing TB contacts. Am J Respir Crit Care Med 175: 618-627, 2007.
9. Ferrara G, Losi M, Meacci M, et al. Routine hospital use of a new commercial whole blood interferon-γ assay for the diagnosis of tuberculosis infection. Am J Respir Crit Care Med 172: 631-635, 2005.
10. Ferrara G, Losi M, D'Amico R, et al. Use in routine clinical practice of two commercial blood tests for diagnosis of infection with Mycobacterium tuberculosis: a prospective study. Lancet 367: 1328-1334, 2006.
11. Piana F, Codecasa LR, Cavallerio P, et al. Use of a T-cell based test for detection of tuberculosis infection among immunocompromised patients. Eur Respir J 28: 31-34, 2006.
12. Kobashi Y, Mouri K, Obase Y, et al. Clinical evaluation of QuantiFERON TB-2 G test for immujnocompromised patients. Eur Respir J 30: 945-950, 2007.
13. American Thoracic Society. Targeted tubedrculin testing and treatment of latent tuberculosis infection. Am J Respir Crit Care Med 161: S221-S247, 2000.
14. Mazurek GH, Jereb J, Lobue P, Iademarco MF, Metchock B, Vernon A. Division of Tuberculosis Elimination, National Center for HIV, STD, and TB Prevention. Guidelines for using the QuantiFERON-TB Gold test for detecting Mycobacterium tuberculosis infection, United States. MMWR Recomm Rep 54: 49-55, 2005.
15. Ewer K, Deeks J, Alvarez L, et al. Comparison of T-cell-based assay with tuberculin skin test for diagnosis of Mycobacterium tuberculosis infection in a school tuberculosis outbreak. Lancet 361: 1168-1173, 2003.
16. Newcombe RG. Two-sided confidence intervals for the single proportion: comparison of seven methods. Stat Med 17: 857-872, 1998.
17. Dewan PK, Grinsdale J, Kawamura LM. Low sensitivity of a whole-blood-interferon-γ release assay for detection of active tuberculosis. Clin Infect Dis 44: 69-73, 2007.
18. Pai M, Riley LW, Colford JM Jr. Interferon-gamma assays in the immunodiagnosis of tuberculosis: a systematic review. Lancet Infect Dis 4: 761-776, 2004.
19. Pai M, Lewinsohn DM. Interferon-γ assays for tuberculosis: is anergy the Achiles' heel? Am J Respir Crit Care Med 172: 519-521, 2005.
20. Doherty TM, Demissie A, Menzies D, et al. Effect of sample handling on analysis of cytokine responses to Mycobacterium tuberculosis in clinical samples using ELISA, ELISPOT and quantitative PCR. J Immunol Methods 298: 129-141, 2005.