Imaging the brain during sniffing: A pilot fMRI study

Pulmonary Pharmacology and Therapeutics

Volumn 22, Issue 2, 2009, Pages 97-101

  Koritnik, Blaž ^a   Azam, Sheba ^b   Andrew, Chris M ^b   Leigh, P Nigel ^b   Williams, Steven C R ^b  

^a UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Cortical motor system; Functional magnetic resonance imaging; Functional neuroimaging; Neural control of respiration; Sniff nasal inspiratory pressure; Sniffing

Indexed keywords

ADULT; ARTICLE; BASAL GANGLION; CEREBELLUM VERMIS; CINGULATE GYRUS; ENTORHINAL CORTEX; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; HUMAN EXPERIMENT; INSULA; MALE; MESENCEPHALON; MOTOR CORTEX; NEUROIMAGING; NORMAL HUMAN; PILOT STUDY; PONS; PREMOTOR CORTEX; PRIORITY JOURNAL; PYRIFORM CORTEX; RESPIRATION CONTROL; RESPIRATORY FUNCTION; SENSORIMOTOR CORTEX; SNIFFING; SUBICULUM; TASK PERFORMANCE; THALAMUS;

ADULT; BRAIN; BRAIN MAPPING; CEREBRAL CORTEX; FEASIBILITY STUDIES; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PILOT PROJECTS; RESPIRATORY MECHANICS;

EID: 61749086697     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2008.10.009     Document Type: Article

References (39)

1. Guz A. Brain, breathing and breathlessness. Respir Physiol 109 (1997) 197-204
2. American Thoracic Society/European Respiratory Society. ATS/ERS Statement on respiratory muscle testing. Am J Respir Crit Care Med 166 (2002) 518-624
3. Mainland J., and Sobel N. The sniff is part of the olfactory percept. Chem Senses 31 (2006) 181-196
4. Miller J.M., Moxham J., and Green M. The maximal sniff in the assessment of diaphragm function in man. Clin Sci 69 (1985) 91-96
5. Cohen M.S., and Bookheimer S.Y. Localization of brain function using magnetic resonance imaging. Trends Neurosci 17 (1994) 268-277
6. Matthews P.M., and Jezzard P. Functional magnetic resonance imaging. J Neurol Neurosurg Psychiatry 75 (2004) 6-12
7. Colebatch J.G., Adams L., Murphy K., Martin A.J., Lammertsma A.A., Tochon-Danguy H.J., et al. Regional cerebral blood flow during volitional breathing in man. J Physiol 443 (1991) 91-103
8. Gozal D., Hathout G.M., Kirlew K.A., Tang H., Woo M.S., Zhang J., et al. Localization of putative neural respiratory regions in the human by functional magnetic resonance imaging. J Appl Physiol 76 (1994) 2076-2083
9. Gozal D., Omidvar O., Kirlew K.A., Hathout G.M., Hamilton R., Lufkin R.B., et al. Identification of human brain regions underlying responses to resistive inspiratory loading with functional magnetic resonance imaging. Proc Natl Acad Sci U S A 92 (1995) 6607-6611
10. Gozal D., Omidvar O., Kirlew K.A., Hathout G.M., Lufkin R.B., and Harper R.M. Functional magnetic resonance imaging reveals brain regions mediating the response to resistive expiratory loads in humans. J Clin Invest 97 (1996) 47-53
11. Ramsay S.C., Adams L., Murphy K., Corfield D.R., Grootoonk S., Bailey D.L., et al. Regional cerebral blood flow during volitional expiration in man: a comparison with volitional inspiration. J Physiol 461 (1993) 85-101
12. Fink G.R., Corfield D.R., Murphy K., Kobayashi I., Dettmers C., Adams L., et al. Human cerebral activity with increasing inspiratory force: a study using positron emission tomography. J Appl Physiol 81 (1996) 1295-1305
13. Brannan S., Liotti M., Egan G., Shade R., Madden L., Robillard R., et al. Neuroimaging of cerebral activations and deactivations associated with hypercapnia and hunger for air. Proc Natl Acad Sci U S A 98 (2001) 2029-2034
14. Evans K.C., Shea S.A., and Saykin A.J. Functional MRI localisation of central nervous system regions associated with volitional inspiration in humans. J Physiol 520 (1999) 383-392
15. McKay L.C., Evans K.C., Frackowiak R.S., and Corfield D.R. Neural correlates of voluntary breathing in humans. J Appl Physiol 95 (2003) 1170-1178
16. Simonyan K., Saad Z.S., Loucks T.M., Poletto C.J., and Ludlow C.L. Functional neuroanatomy of human voluntary cough and sniff production. Neuroimage 37 (2007) 401-409
17. Friston K.J., Holmes A.P., Worsley K.J., Poline J.P., Frith C.D., and Frackowiak R.S.J. Statistical parametric maps in functional imaging: a general linear approach. Hum Brain Mapp 2 (1995) 189-210
18. Quanjer P.H., Tammeling G.J., Cotes J.E., Pedersen O.F., Peslin R., and Yernault J.C. Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J Suppl 16 (1993) 5-40
19. Uldry C., and Fitting J.W. Maximal values of sniff nasal inspiratory pressure in healthy subjects. Thorax 50 (1995) 371-375
20. Roland P.E., and Zilles K. Functions and structures of the motor cortices in humans. Curr Opin Neurobiol 6 (1996) 773-781
21. Mazzone S.B., McLennan L., McGovern A.E., Egan G.F., and Farrell M.J. Representation of capsaicin-evoked urge-to-cough in the human brain using functional magnetic resonance imaging. Am J Respir Crit Care Med 176 (2007) 327-332
22. Nava S., Ambrosino N., Crotti P., Fracchia C., and Rampulla C. Recruitment of some respiratory muscles during three maximal inspiratory manoeuvres. Thorax 48 (1993) 702-707
23. Katagiri M., Abe T., Yokoba M., Dobashi Y., Tomita T., and Easton P.A. Neck and abdominal muscle activity during a sniff. Respir Med 97 (2003) 1027-1035
24. Foerster O. Motorische Felder und Bahen. In: Bumke O., and Foerster O. (Eds). Handbuch der Neurologie (1936), Springer, Berlin 50-51
25. Gandevia S.C., and Rothwell J.C. Activation of the human diaphragm from the motor cortex. J Physiol 384 (1987) 109-118
26. Maskill D., Murphy K., Mier A., Owen M., and Guz A. Motor cortical representation of the diaphragm in man. J Physiol 443 (1991) 105-121
27. Sharshar T., Hopkinson N.S., Jonville S., Prigent H., Carlier R., Dayer M.J., et al. Demonstration of a second rapidly conducting cortico-diaphragmatic pathway in humans. J Physiol 560 (2004) 897-908
28. Picard N., and Strick P.L. Motor areas of the medial wall: a review of their location and functional activation. Cereb Cortex 6 (1996) 342-353
29. Henson R.N., Price C.J., Rugg M.D., Turner R., and Friston K.J. Detecting latency differences in event-related BOLD responses: application to words versus nonwords and initial versus repeated face presentations. Neuroimage 15 (2002) 83-97
30. Macefield G., and Gandevia S.C. The cortical drive to human respiratory muscles in the awake state assessed by premotor cerebral potentials. J Physiol 439 (1991) 545-558
31. Corfield D.R., Murphy K., and Guz A. Does the motor cortical control of the diaphragm 'bypass' the brain stem respiratory centres in man. Respir Physiol 114 (1998) 109-117
32. McKay L.C., Adams L., Frackowiak R.S., and Corfield D.R. A bilateral cortico-bulbar network associated with breath holding in humans, determined by functional magnetic resonance imaging. Neuroimage 40 (2008) 1824-1832
33. Sobel N., Prabhakaran V., Desmond J.E., Glover G.H., Goode R.L., Sullivan E.V., et al. Sniffing and smelling: separate subsystems in the human olfactory cortex. Nature 392 (1998) 282-286
34. Kareken D.A., Sabri M., Radnovich A.J., Claus E., Foresman B., Hector D., et al. Olfactory system activation from sniffing: effects in piriform and orbitofrontal cortex. Neuroimage 22 (2004) 456-465
35. Hajnal J.V., Myers R., Oatridge A., Schwieso J.E., Young I.R., and Bydder G.M. Artifacts due to stimulus correlated motion in functional imaging of the brain. Magn Reson Med 31 (1994) 283-291
36. Birn R.M., Bandettini P.A., Cox R.W., Jesmanowicz A., and Shaker R. Magnetic field changes in the human brain due to swallowing or speaking. Magn Reson Med 40 (1998) 55-60
37. Birn R.M., Bandettini P.A., Cox R.W., and Shaker R. Event-related fMRI of tasks involving brief motion. Hum Brain Mapp 7 (1999) 106-114
38. Birn R.M., Smith M.A., Jones T.B., and Bandettini P.A. The respiration response function: the temporal dynamics of fMRI signal fluctuations related to changes in respiration. Neuroimage 40 (2008) 644-654
39. Corfield D.R., Murphy K., Josephs O., Adams L., and Turner R. Does hypercapnia-induced cerebral vasodilation modulate the hemodynamic response to neural activation. Neuroimage 13 (2001) 1207-1211