5′-Untranslated region of the tryptophan hydroxylase-2 gene harbors an asymmetric bidirectional promoter but not internal ribosome entry site in vitro

Gene

Volumn 435, Issue 1-2, 2009, Pages 53-62

  Chen, Guo Lin ^a   Miller, Gregory M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Antisense transcript; Bidirectional promoter; Gene expression; Internal ribosome entry site; Serotonin; Tryptophan hydroxylase 2

Indexed keywords

TRYPTOPHAN HYDROXYLASE 2; MESSENGER RNA; TPH2 PROTEIN, HUMAN; TRYPTOPHAN HYDROXYLASE; UNTRANSLATED RNA;

5' UNTRANSLATED REGION; ARTICLE; CELL ACTIVITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERNAL RIBOSOME ENTRY SITE; MOLECULAR CLONING; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; RIBONUCLEASE PROTECTION ASSAY; RNA TRANSLATION; BIOLOGICAL MODEL; CELL CULTURE; DNA METHYLATION; GENETICS; METABOLISM; MOLECULAR GENETICS; RIBOSOME;

5' UNTRANSLATED REGIONS; BASE SEQUENCE; CELLS, CULTURED; DNA METHYLATION; GENE SILENCING; HUMANS; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS, GENETIC; RIBOSOMES; RNA, MESSENGER; RNA, UNTRANSLATED; TRANSFECTION; TRYPTOPHAN HYDROXYLASE;

EID: 61649125986     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gene.2008.12.019     Document Type: Article

References (67)

1. Baird S.D., Turcotte M., Korneluk R.G., and Holcik M. Searching for IRES. RNA 12 (2006) 1755-1785
2. Bender T.P., Thompson C.B., and Kuehl W.M. Differential expression of c-myb mRNA in murine B lymphomas by a block to transcription elongation. Science 237 (1987) 1473-1476
3. Brown S.M., et al. A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity. Mol. Psychiatry 10 (2005) 884-888
4. Brown H.J., Henderson L.A., and Keay K.A. Hypotensive but not normotensive haemorrhage increases tryptophan hydroxylase-2 mRNA in caudal midline medulla. Neurosci. Lett. 398 (2006) 314-318
5. Calcagno E., Canetta A., Guzzetti S., Cervo L., and Invernizzi R.W. Strain differences in basal and post-citalopram extracellular 5-HT in the mouse medial prefrontal cortex and dorsal hippocampus, relation with tryptophan hydroxylase-2 activity. J. Neurochem. 103 (2007) 1111-1120
6. Canli T., Congdon E., Gutknecht L., Constable R.T., and Lesch K.P. Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation. J. Neural Transm. 112 (2005) 1479-1485
7. Cervo L., et al. Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression. J. Neurosci. 25 (2005) 8165-8172
8. Chen J., et al. Over 20% of human transcripts might form sense-antisense pairs. Nucleic Acids Res. 32 (2004) 4812-4820
9. Chen G.L., Novak M.A., Hakim S., Xie Z., and Miller G.M. Tryptophan hydroxylase-2 gene polymorphisms in rhesus monkeys, association with hypothalamic-pituitary-adrenal axis function and in vitro gene expression. Mol. Psychiatry 11 (2006) 914-928
10. Chen G.L., Vallender E.J., and Miller G.M. Functional characterization of the human TPH2 5′ regulatory region, untranslated region and polymorphisms modulate gene expression in vitro. Hum. Genet 122 (2008) 645-657
11. Cichon S., et al. Brain-specific tryptophan hydroxylase 2 (TPH2), a functional Pro206Ser substitution and variation in the 5′-region are associated with bipolar affective disorder. Hum. Mol. Genet. 17 (2008) 87-97
12. Clark J.A., Pai L.Y., Flick R.B., and Rohrer S.P. Differential hormonal regulation of tryptophan hydroxylase-2 mRNA in the murine dorsal raphe nucleus. Biol. Psychiatry 57 (2005) 943-946
13. Coon H., et al. Possible association between autism and variants in the brain-expressed tryptophan hydroxylase gene (TPH2). Am. J. Med. Genet., B Neuropsychiatr. Genet. 135 (2005) 42-46
14. Côté F., et al. Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 13525-13530
15. Davuluri R.V., Suzuki Y., Sugano S., and Zhang M.Q. CART classification of human 5′ UTR sequences. Genome Res. 10 (2000) 1807-1816
16. Davuluri R.V., Suzuki Y., Sugano S., Plass C., and Huang T.H. The functional consequences of alternative promoter use in mammalian genomes. Trends Genet. 24 (2008) 167-177
17. Dinan T.G. Serotonin and the regulation of hypothalamic-pituitary-adrenal axis function. Life Sci. 58 (1996) 1683-1694
18. Goertzel B.N., Pennachin C., de Souza Coelho L., Gurbaxani B., Maloney E.M., and Jones J.F. Combinations of single nucleotide polymorphisms in neuroendocrine effector and receptor genes predict chronic fatigue syndrome. Pharmacogenomics 7 (2006) 475-483
19. Gotlib I.H., Joormann J., Minor K.L., et al. HPA axis reactivity: a mechanism underlying the associations among 5-HTTLPR, stress, and depression. Biol. Psychiatry 63 (2008) 847-851
20. Gutknecht L., et al. Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation. Int. J. Neuropsychopharmacol. 10 (2007) 309-320
21. Haghighi F., et al. Genetic architecture of the human tryptophan hydroxylase 2 gene: existence of neural isoforms and relevance for major depression. Mol. Psychiatry 13 (2008) 813-820
22. Han B., and Zhang J.T. Regulation of gene expression by internal ribosome entry sites or cryptic promoters, the eIF4G story. Mol. Cell. Biol. 22 (2002) 7372-7384
23. Harvey M., et al. Support for the involvement of TPH2 gene in affective disorders. Mol. Psychiatry. 9 (2004) 980-981
24. Henz S.R., et al. Distinct expression patterns of natural antisense transcripts in Arabidopsis. Plant Physiol. 144 (2007) 1247-1255
25. Herrmann M.J., et al. Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on emotional processing. Cereb. Cortex 17 (2007) 1160-1163
26. Hiroi R., McDevitt R.A., and Neumaier J.F. Estrogen selectively increases tryptophan hydroxylase-2 mRNA expression in distinct subregions of rat midbrain raphe nucleus, association between gene expression and anxiety behavior in the open field. Biol. Psychiatry 60 (2006) 288-295
27. Holcik M., Graber T., Lewis S.M., Lefebvre C.A., Lacasse E., and Baird S. Spurious splicing within the XIAP 5′ UTR occurs in the Rluc/Fluc but not the betagal/CAT bicistronic reporter system. RNA 11 (2005) 1605-1609
28. Jollant F., et al. The influence of four serotonin-related genes on decision-making in suicide attempters. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (2007) 615-624
29. Kawaji H., and Hayashizaki Y. Exploration of small RNAs. PLoS Genet. 4 (2008) e22
30. Kawaji H., et al. Hidden layers of human small RNAs. BMC Genomics 9 (2008) 157
31. Kozak M. A second look at cellular mRNA sequences said to function as internal ribosome entry sites. Nucleic Acids Res. 33 (2005) 6593-6602
32. Krystal G., et al. Multiple mechanisms for transcriptional regulation of the myc gene family in small-cell lung cancer. Mol. Cell. Biol. 8 (1988) 3373-3381
33. Liang J., Wessel III J.H., Iuvone P.M., Tosini G., and Fukuhara C. Diurnal rhythms of tryptophan hydroxylase 1 and 2 mRNA expression in the rat retina. NeuroReport 15 (2004) 1497-1500
34. Liu Z., Dong Z., Han B., Yang Y., Liu Y., and Zhang J.T. Regulation of expression by promoters versus internal ribosome entry site in the 5′-untranslated sequence of the human cyclin-dependent kinase inhibitor p27kip1. Nucleic Acids Res. 33 (2005) 3763-3771
35. Lopez V.A., Detera-Wadleigh S., Cardona I., Kassem L., McMahon F.J., and The National Institute of Mental Health Genetics Initiative Bipolar Disorder Consortium. Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attempts. Biol. Psychiatry 61 (2007) 181-186
36. Lopez de Lara C., et al. Effect of tryptophan hydroxylase-2 gene variants on suicide risk in major depression. Biol. Psychiatry 62 (2007) 72-80
37. Lowry C.A. Functional subsets of serotonergic neurones: implications for control of the hypothalamic-pituitary-adrenal axis. J. Neuroendocrinol. 14 (2002) 911-923
38. Malek Z.S., Dardente H., Pevet P., and Raison S. Tissue-specific expression of tryptophan hydroxylase mRNAs in the rat midbrain, anatomical evidence and daily profiles. Eur. J. Neurosci. 22 (2005) 895-901
39. Malek Z.S., Sage D., Pevet P., and Raison S. Daily rhythm of tryptophan hydroxylase-2 mRNA within Raphe neurons is induced by corticoid daily surge and modulated by enhanced locomotor activity. Endocrinology 148 (2007) 5165-5172
40. Maron E., et al. Association study of tryptophan hydroxylase 2 gene polymorphisms in panic disorder. Neurosci. Lett. 411 (2007) 180-184
41. Mehler M.F., and Mattick J.S. Non-coding RNAs in the nervous system. J. Physiol. 575 Pt 2 (2006) 333-341
42. Mette M.F., Aufsatz W., van der Winden J., Matzke M.A., and Matzke A.J. Transcriptional silencing and promoter methylation triggered by double-stranded RNA. EMBO J. 19 (2000) 5194-5201
43. Mössner R., et al. Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder. Int. J. Neuropsychopharmacol. 9 (2006) 437-442
44. Nielsen D.A., et al. TPH2 and TPH1: association of variants and interactions with heroin addiction. Behav. Genet. 38 (2008) 133-150
45. Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 36 (2004) 40-45
46. Patel P.D., Bochar D.A., Turner D.L., Meng F., Mueller H.M., and Pontrello C.G. Regulation of tryptophan hydroxylase-2 gene expression by a bipartite RE-1 silencer of transcription/neuron restrictive silencing factor (REST/NRSF) binding motif. J. Biol. Chem. 282 (2007) 26717-26724
47. Peters E.J., Slager S.L., McGrath P.J., Knowles J.A., and Hamilton S.P. Investigation of serotonin-related genes in antidepressant response. Mol. Psychiatry 9 (2004) 879-889
48. Pruunsild P., Kazantseva A., Aid T., Palm K., and Timmusk T. Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters. Genomics 90 (2007) 397-406
49. Reuter M., Hennig J., Amelang M., Montag C., Korkut T., Hueweler A., and Stürmer T. The role of the TPH1 and TPH2 genes for nicotine dependence: a genetic association study in two different age cohorts. Neuropsychobiology 56 (2007) 47-54
50. Reuter M., Kuepper Y., and Hennig J. Association between a polymorphism in the promoter region of the TPH2 gene and the personality trait of harm avoidance. Int. J. Neuropsychopharmacol. 10 (2007) 401-404
51. Sanchez R.L., Reddy A.P., Centeno M.L., Henderson J.A., and Bethea C.L. A second tryptophan hydroxylase isoform, TPH-2 mRNA, is increased by ovarian steroids in the raphe region of macaques. Brain Res. Mol. Brain Res. 135 (2005) 194-203
52. Sandelin A., Carninci P., Lenhard B., Ponjavic J., Hayashizaki Y., and Hume D.A. Mammalian RNA polymerase II core promoters: insights from genome-wide studies. Nat. Rev., Genet. 8 (2007) 424-436
53. Sheehan K., et al. Tryptophan hydroxylase 2 (TPH2) gene variants associated with ADHD. Mol. Psychiatry 10 (2005) 944-949
54. Shishkina G.T., Kalinina T.S., and Dygalo N.N. Up-regulation of tryptophan hydroxylase-2 mRNA in the rat brain by chronic fluoxetine treatment correlates with its antidepressant effect. Neuroscience 150 (2007) 404-412
55. Smith A.K., White P.D., Aslakson E., Vollmer-Conna U., and Rajeevan M.S. Polymorphisms in genes regulating the HPA axis associated with empirically delineated classes of unexplained chronic fatigue. Pharmacogenomics 7 (2006) 387-394
56. Spicer D.B., and Sonenshein G.E. An antisense promoter of the murine c-myc gene is localized within intron 2. Mol. Cell. Biol. 12 (1992) 1324-1329
57. Trinklein N.D., Aldred S.F., Hartman S.J., Schroeder D.I., Otillar R.P., and Myers R.M. An abundance of bidirectional promoters in the human genome. Genome Res. 14 (2004) 62-66
58. Tufarelli C., et al. Transcription of antisense RNA leading to gene silencing and methylation as a novel cause of human genetic disease. Nat. Genet. 34 (2003) 157-165
59. Tzvetkov M.V., Brockmöller J., Roots I., and Kirchheiner J. Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment. Pharmacogenet. Genomics 18 (2008) 495-506
60. Walitza S., et al. Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder. Mol. Psychiatry 10 (2005) 1126-1132
61. Walther D.J., and Bader M. A unique central tryptophan hydroxylase isoform. Biochem. Pharmacol. 66 (2003) 1673-1680
62. Walther D.J., et al. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299 (2003) 76
63. Wang Z., Weaver M., and Magnuson N.S. Cryptic promoter activity in the DNA sequence corresponding to the pim-1 5′-UTR. Nucleic Acids Res. 33 (2005) 2248-2258
64. Zhang X., Beaulieu J.M., Sotnikova T.D., Gainetdinov R.R., and Caron M.G. Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science 305 (2004) 217
65. Zhou Z., et al. Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations. Arch. Gen. Psychiatry 62 (2005) 1109-1118
66. Zill P., et al. SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression. Mol. Psychiatry 9 (2004) 1030-1036
67. Zill P., Buttner A., Eisenmenger W., Moller H.J., Bondy B., and Ackenheil M. Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims. Biol. Psychiatry 56 (2004) 581-586