Effect of PEG6000 on the in vitro and in vivo transdermal permeation of ondansetron hydrochloride from EVA1802 membranes

Pharmaceutical Development and Technology

Volumn 14, Issue 1, 2009, Pages 53-64

  Krishnaiah, Yellela S R ^a   Rama, Bukka ^b   Raghumurthy, Vanambattina ^b   Ramanamurthy, Kolapalli V ^b   Satyanarayana, Vemulapalli ^c  

^a KUWAIT UNIVERSITY   (Kuwait)

^b ANDHRA UNIVERSITY   (India)

^c Sipra Labs Pvt Ltd   (India)

Author keywords

EVA1802 membrane; Human volunteers; In vivo evaluation; Nerodilol; Ondansetron; PEG6000; Transdermal

Indexed keywords

ADHESIVE AGENT; DOXAZOSIN; ETHYLENE VINYL ACETATE 1802; ETHYLENE VINYL ACETATE COPOLYMER; MACROGOL 6000; ONDANSETRON; UNCLASSIFIED DRUG;

ADULT; ANIMAL TISSUE; ARTICLE; COMPOSITE SKIN GRAFT; CONTROLLED STUDY; DERMIS; DRUG BLOOD LEVEL; DRUG PENETRATION; DRUG RELEASE; DRUG TRANSPORT; EMULSION; EPIDERMIS; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; MALE; MEMBRANE PERMEABILITY; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; RAT; STEADY STATE; TRANSDERMAL PATCH;

EID: 61649123795     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.1080/10837450802409404     Document Type: Article

References (20)

1. Markham A, Sorkin EM. Ondansetron: an update of its therapeutic use in chemotherapy-induced and postoperative nausea and vomiting. Drugs 1993;45:931-952.
2. Takahashi K, Rytting JH. Novel approach to improve permeation of ondansetron across shed snake skin as a model membrane. J. Pharm. Pharmacol. 2001;53:789-794.
3. Dimas DA, Dallas PP, Rekkas DM. Ion pair formation as a possible mechanism for the enhancement effect of lauric acid on the transdermal permeation of ondansetron. Pharm. Dev. Technol. 2004;9:311-320.
4. Dimas DA, Dallas PP, Rekkas DM. Use of an 8(1)3(2) asymmetrical factorial design for the in vitro evaluation of ondansetron permeation through human epidermis. Pharm. Dev. Technol. 2004;9:39-48.
5. Gwak, HS, Oh IS, Chun IK. Transdermal delivery of ondansetron hydrochloride: effects of vehicles and penetration enhancers. Drug Dev. Ind. Pharm. 2004;30:187-194.
6. Gwak HS, Oh IS, Chun IK. In vitro percutaneous absorption of ondansetron hydrochloride from pressure-sensitive adhesive matrices through hairless mouse skin. Arch. Pharm. Res. 2003;26:644-648.
7. Krishnaiah YSR, Shiva Kumar M, Raju V, Lakshmi M, Rama B. Penetration enhancing effect of ethanolic solution of menthol on transdermal permeation of ondansetron hydrochloride across rat epidermis. Drug Deliv. 2008;15:227-234.
8. Krishnaiah YSR, Raju V, Shiva Kumar, Rama B, Raghumurthy V, Ramanamurthy KV. Studies on optimizing in vitro transdermal permeation of ondansetron hydrochloride using nerodilol, carvone and limonene as penetration enhancers. Pharm. Dev. Technol. 2008;13:177-185.
9. Krishnaiah YSR, Satyanarayana V, Bhaskar P. Formulation and in vivo evaluation of membrane-moderated transdermal therapeutic systems of nicardipine hydrochloride using carvone as a penetration enhancer. Drug Deliv. 2003; 10:101-109.
10. Keshary PR, Chien YW. Mechanism of transdermal controlled nitroglycerin administration. Part 2. Assessment of rate controlling steps. Drug Dev. Ind. Pharm. 1984;10:1663-1699.
11. Barry B. Transdermal drug delivery. In: Aulton ME, ed. Pharmaceutics: The Science of Dosage Form Design. 2nd ed. London: Churchill Livingstone; 2002:499-533.
12. Bozigian HP, Pritchard JF, Gooding AE, Pakes GE. Ondansetron absorption in adults: effect of dosage form, food, and antacids. J. Pharm. Sci. 1994;83:1011-1013.
13. Makhija SN, Vavia PR. Controlled porosity osmotic pump-based controlled release systems of pseudoephedrine. I. Cellulose acetate as a semipermeable membrane. J. Control. Release. 2003;89:5-18.
14. Schulze Nahrup J, Gao ZM, Mark JE, Sakr A. Poly(dimethylsiloxane) coatings for controlled drug release - polymer modifications. Int. J. Pharm. 2004;270:199-208.
15. Rahman NU, Yuen KH. Eudragit NE40-drug mixed coating system for controlling drug release of core pellets. Drug Dev. Ind. Pharm. 2005;31:339-347.
16. Musolf MC. Pressure-sensitive adhesives: science and engineering. In: Chien YW, ed. Transdermal Controlled Systemic Medications. New York: Marcel Dekker; 1987:93-112.
17. Krishnaiah YSR, Satyanarayana V, Bhaskar P. Influence of menthol and pressure sensitive adhesives on the in vivo performance of membrane-moderated transdermal therapeutic system of nicardipine hydrochloride in human volunteers. Eur. J. Pharm. Biopharm. 2003;55:329-337.
18. Diez I, Colom H, Moreno J, Obach R, Peraire C, Domenech J. A comparative in vitro study of transdermal absorption of a series of calcium channel antagonists. J. Pharm. Sci. 1991;80:931-934.
19. Hunt JN, Spurrell WR. The pattern of emptying of the human stomach. J. Physiol. 1951;113:157-168.
20. Hunt JN. Gastric emptying and secretion in man. Physiol. Rev. 1959;39:491-533.