Ro 60 functions as a receptor for β2-glycoprotein I on apoptotic cells

Arthritis and Rheumatism

Volumn 60, Issue 3, 2009, Pages 860-869

  Reed, Joanne H ^a,b   Giannakopoulos, Bill ^c   Jackson, Michael W ^a,b   Krilis, Steven A ^c   Gordon, Tom P ^a,b  

^a FLINDERS UNIVERSITY   (Australia)

^b FLINDERS MEDICAL CENTRE   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; BETA2 GLYCOPROTEIN 1; IMMUNOGLOBULIN G; RO 60 AUTOANTIGEN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL SURFACE; COMPETITIVE INHIBITION; FLOW CYTOMETRY; HUMAN; IN VITRO STUDY; MUTANT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION;

ANTIGEN-ANTIBODY COMPLEX; APOPTOSIS; AUTOANTIBODIES; AUTOANTIGENS; BETA 2-GLYCOPROTEIN I; CELL LINE; EPITHELIAL CELLS; EPITOPES; HUMANS; JURKAT CELLS; PROTEIN BINDING; RECEPTORS, CELL SURFACE; RIBONUCLEOPROTEINS; RNA, SMALL CYTOPLASMIC;

EID: 61649120433     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.24361     Document Type: Article

References (36)

1. Harley JB, Scofield AN. Systemic lupus erythematosus: RNA protein autoantigens, models of disease heterogeneity, and theories of etiology. J Clin Immunol 1991;11:297-307.
2. Buyon JP, Clancy RM. Maternal autoantibodies and congenital heart block: mediators, markers, and therapeutic approach. Semin Arthritis Rheum 2003;33:140-54.
3. Clancy RM, Neufing PJ, Zheng P, O'Mahony M, Nimmerjahn F, Gordon TP, et al. Impaired clearance of apoptotic cardiocytes is linked to anti-SSA/Ro and -SSB/La antibodies in the pathogenesis of congenital heart block. J Clin Invest 2006;116:2413-22.
4. Reed JH, Jackson MW, Gordon TP. A B cell apotope of Ro 60 in systemic lupus erythematosus. Arthritis Rheum 2008;58:1125-9.
5. 2-glycoprotein I (apolipoprotein H). Proc Natl Acad Sci U S A 1990;87:4120-4.
6. Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cevera R, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006;4:295-306.
7. Giannakopoulos B, Passam F, Rahgozar S, Krilis SA. Current concepts of the pathogenesis of the antiphospholipid syndrome. Blood 2007;109:422-30.
8. 2 glycoprotein I - function in health and disease. Thromb Res 2004;114:335-46.
9. 2-glycoprotein I macrophage interactions: implications for apoptotic cell clearance by phagocytes. J Biol Chem 1998;273:29272-7.
10. 2-glycoprotein I in macrophage recognition. J Biol Chem 1997; 272:31113-7.
11. 2-glycoprotein I-dependent manner. J Immunol 1996;157:2201-8.
12. Balasubramanian K, Maiti SN, Schroit AJ. Recruitment of beta-2-glycoprotein I to cell surfaces in extrinsic and intrinsic apoptosis. Apoptosis 2005;10:439-46.
13. 2 glycoprotein I is a major protein associated with very rapidly cleared liposomes in vivo, suggesting a significant role in the immune clearance of "non-self" particles. J Biol Chem 1995;270:25845-9.
14. Maiti SN, Balasubramanian K, Ramoth JA, Schroit AJ. β-2-glycoprotein I-dependent macrophage uptake of apoptotic cells: binding to lipoprotein receptor-related protein receptor family members. J Biol Chem 2008;283:3761-6.
15. Levine JS, Subang R, Nasr SH, Fournier S, Lajoie G, Wither J, et al. Immunization with an apoptotic cell-binding protein recapitulates the nephritis and sequential autoantibody emergence of systemic lupus erythematosus. J Immunol 2006;177:6504-16.
16. 2-glycoprotein I antibodies from autoantibody and immunized sources. J Autoimmun 2000;15:91-6.
17. Gordon TP, Kinoshita G, Cavill D, Keech CL, Farris AD, Kaufman K, et al. Restricted specificity of intermolecular spreading to endogenous La (SS-B) and 60 kDa Ro (SS-A) in experimental autoimmunity. Scand J Immunol 2002;56:168-73.
18. 2-glycoprotein I and prothrombin. Clin Exp Immunol 2001;124: 502-8.
19. Reed JH, Neufing PJ, Jackson MW, Clancy RM, Buyon JP, Gordon TP. Different temporal expression of immunodominant Ro60/60 kDa-SSA and La/SSB apotopes. Clin Exp Immunol 2007;148:153-60.
20. Topfer F, Gordon TP, McCluskey J. Intra- and intermolecular spreading of autoimmunity involving the nuclear self-antigens La (SS-B) and Ro (SS-A). Proc Natl Acad Sci U S A 1995;92:875-9.
21. Keech CL, Gordon TP, McCluskey J. The immune response to 52-kilodalton Ro and 60-kilodalton Ro is linked in experimental autoimmunity. J Immunol 1996;157:3694-9.
22. Neufing PJ, Clancy RM, Jackson MW, Tran HB, Buyon JP, Gordon TP. Exposure and binding of selected immunodominant La/SSB epitopes on human apoptotic cells. Arthritis Rheum 2005;52:3934-42.
23. Keech CL, McCluskey J, Gordon TP. Transfection and overexpression of the human 60-kDa Ro/SSA autoantigen in HEp-2 cells. Clin Immunol Immunopathol 1994;73:146-51.
24. Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C. A novel assay for apoptosis: flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods 1995;184:39-51.
25. 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2′. J Biol Chem 2003;278:33831-8.
26. 2- glycoprotein I and prothrombin to phosphatidylserine-exposing blood platelets. Biochem J 2005;62:1514-25.
27. Stein AJ, Fuchs G, Fu C, Wolin SL, Reinisch KM. Structural insights into RNA quality control: the Ro autoantigen binds misfolded RNAs via its central cavity. Cell 2005;121:529-39.
28. Purcell AW, Todd A, Kinoshita G, Lynch TA, Keech CL, Gething MJ, et al. Association of stress proteins with autoantigens: a possible mechanism for triggering autoimmunity? Clin Exp Immunol 2003;132:193-200.
29. Brucato A, Frassi M, Franceschini F, Cimaz R, Faden D, Pisoni MP, et al. Risk of congenital complete heart block in newborns of mothers with anti-Ro/SSA antibodies detected by counterimmunoelectrophoresis: a prospective study of 100 women. Arthritis Rheum 2001;44:1832-5.
30. Buyon JP, Clancy RM. Dying right to live longer: positing apoptosis as a link between maternal autoantibodies and congenital heart block. Lupus 2008;17:86-90.
31. 2-glycoprotein-I to human serum lipoproteins: distribution among density fractions. FEBS Lett 1979;102:183-6.
32. 2 glycoprotein-1 and the influence of plasma lipids. Thromb Res 1993; 72:275-86.
33. 2-glycoprotein I. Eur J Biochem 2003;270:230-8.
34. 2-glycoprotein I and its clinical significance: from gene sequence to protein levels. Autoimmun Rev 2007;6:547-52.
35. Arbuckle MR, McClain MT, Rubertone MV, Scofield RH, Dennis GJ, James JA, et al. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med 2003;349:1526-33.
36. McClain MT, Arbuckle MR, Heinlen LD, Dennis GJ, Roebuck J, Rubertone MV, et al. The prevalence, onset, and clinical significance of antiphospholipid antibodies prior to diagnosis of systemic lupus erythematosus. Arthritis Rheum 2004;50:1226-32.