Laboratory diagnosis of Clostridium difficile-associated diarrhoea: Microbiologists (should) do it with culture

Pathology

Volumn 41, Issue 2, 2009, Pages 187-188

  Jaksic, A Sasha ^a   Nimmo, Graeme R ^a   Dwyer, Brian W ^b  

^a Central Queensland Pathology Laboratory   (Australia)

^b PRINCESS ALEXANDRA HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; QUINOLONE DERIVATIVE;

CELL CULTURE; CLOSTRIDIUM DIFFICILE INFECTION; DISEASE SEVERITY; HEALTH CARE FACILITY; HUMAN; IMMUNOASSAY; INFECTION CONTROL; LETTER; MICROBIOLOGY; REAL TIME POLYMERASE CHAIN REACTION;

EID: 61649114488     PISSN: 00313025     EISSN: 14653931     Source Type: Journal    
DOI: 10.1080/00313020802579235     Document Type: Article

References (14)

1. Elliott B, Chang BJ, Golledge CL, Riley TV. Clostridium difficile-associated diarrhoea. Intern Med J 2007; 37: 561-8.
2. Kuijper EJ, Coignard B, Tull P, ESCMID Study Group for Clostridium difficile; EU Member States; European Centre for Diseases Prevention and Control. Emergence of Clostridium difficile-associated disease in North America and Europe. Clin Microbiol Infect 2006; (Suppl 6): 2-18.
3. McDonald LC, Killgore GE, Thompson A, et al. An epidemic, toxin gene-variant strain of Clostridium difficile. N Engl J Med 2005; 353: 2433-41.
4. Loo VG, Poirier L, Miller MA, et al. Predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med 2005; 353: 2442-9.
5. Gerding DN. New definitions will help, but cultures are critical for resolving unanswered questions about Clostridium difficile. Infect Control Hosp Epidemiol 2007; 28: 113-15, 2007.
6. Delmee M, Van Broeck J, Simon A, Janssens M, Avesani V. Laboratory diagnosis of Clostridium difficile-associated diarrhoea; a plea for culture. J Med Microbiol 2005; 54: 187-91.
7. Peterson LR, Manson RU, Paule SM, et al. Detection of toxigenic Clostridium difficile in stool samples by real-time polymerase chain reaction for the diagnosis of C. difficile-associated diarrhea. Clin Infect Dis 2007; 45: 1152-60.
8. Bartlett JG, Gerding DN. Clinical recognition and diagnosis of Clostridium difficile infection. Clin Infect Dis 2008; 46: S12-18.
9. Johal SS, Hammond J, Solomin K, James PD, Mahida YR. Clostrodium difficile associated diarrhoea in hospitalised patients: onset in the community and role of flexible sigmoidoscopy. Gut 2004; 53: 673-7.
10. Kim KH, Fekety R, Batts DH, et al. Isolation of Clostridium difficile from the environment and contacts of patients with antibiotic-associated colitis. J Infect Dis 1981; 143: 42-50.
11. Riggs MM, Sethi AJ, Zabarsky TF, Eckstein EC, Jump RLP, Donskey CJ. Asymptomatic carriers are a potential source of transmission of epidemic and nonepidemic Clostridium difficile strains among Long-Term Care Facility residents. Clin Infect Dis 2007; 45: 992-8.
12. Muto CA. Asymptomatic Clostridium difficile colonisation: Is this the tip of another iceberg? Clin Infect Dis 2007; 45: 999-1000.
13. Ticehurst JR, Aird DZ, Dam LM, Borek AP, Hargrove JT, Carroll KC. Effective detection of toxigenic Clostridium difficile by a two-step algorithm including tests for antigen and cytotoxin. J Clin Microbiol 2006; 44: 1145-9.
14. Fenner L, Widmer AF, Goy G, Rudin S, Frei R. Rapid and reliable diagnostic algorithm for detection of Clostridium difficile. J Clin Microbiol 2008; 46: 328-30.