Prostaglandin E2 receptors and COX enzymes in human hepatocellular carcinoma: Role in the regulation of cell growth

Annals of the New York Academy of Sciences

Volumn 1155, Issue , 2009, Pages 300-308

  Cusimano, Antonella ^a   Foderà, Daniela ^a   Lampiasi, Nadia ^a   Azzolina, Antonina ^a   Notarbartolo, Monica ^b   Giannitrapani, Lydia ^b   D'Alessandro, Natale ^b   Montalto, Giuseppe ^b   Cervello, Melchiorre ^a  

^a CNR   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

Author keywords

Cell growth; COX 1; COX 2; EP receptors; Hepatocellular carcinoma (HCC); NSAIDs

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; MESSENGER RNA; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E1; PROSTAGLANDIN E2; PROSTAGLANDIN E3; PROSTAGLANDIN E4; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; PROSTAGLANDIN SYNTHASE;

ADULT; AGED; ANTINEOPLASTIC ACTIVITY; CELL GROWTH; CELL VIABILITY; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE ASSOCIATION; DOSE RESPONSE; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LIVER CELL CARCINOMA; MALE; POLYMERASE CHAIN REACTION; ARTICLE; CELL DIVISION; ENZYMOLOGY; LIVER TUMOR; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

AGED; CARCINOMA, HEPATOCELLULAR; CELL DIVISION; CELL LINE, TUMOR; FEMALE; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RECEPTORS, PROSTAGLANDIN E;

EID: 61649112686     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.03701.x     Document Type: Conference Paper

References (26)

1. Husain, S.S., I.L. Szabo & A.S. Tarnawski. 2002. NSAID inhibition of GI cancer growth: Clinical implications and molecular mechanisms of action. Am. J. Gastroenterol. 97 : 542 553.
2. Sano, H., Y. Kawahito, R.L. Wilder, et al. 1995. Expression of cyclooxygenase-1 and cyclooxygenase-2 in human colorectal cancer. Cancer Res. 55 : 3785 3789.
3. Brecher, A.R. 2002. The role of cyclooxygenase-2 in the pathogenesis of skin cancer. J. Drugs Dermatol. 1 : 44 47.
4. Hwang, D., D. Scollard, J. Byrne & E. Levine. 1998. Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer. J. Natl. Cancer Inst. 90 : 455 460.
5. Steinbach, G., P.M. Lynch, R.K. Phillips, et al. 2000. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N. Engl. J. Med. 342 : 194619 194652.
6. Takeda, H., M. Sonoshita, H. Oshima, et al. 2003. Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis. Cancer Res. 63 : 4872 4877.
7. Kitamura, T., T. Kawamori, N. Uchiya, et al. 2002. Inhibitory effects of mofezolac, a cyclooxygenase-1 selective inhibitor, on intestinal carcinogenesis. Carcinogenesis 23 : 1463 1466.
8. Koga, H., S. Sakisaka, M. Ohishi, et al. 1999. Expression of cyclooxygenase-2 in human hepatocellular carcinoma: Relevance to tumor dedifferentiation. Hepatology 29 : 688 689.
9. Lampiasi, N., D. Foderà, N. D'Alessandro, et al. 2006. The selective cyclooxygenase-1 inhibitor SC-560 suppresses cell proliferation and induces apoptosis in human hepatocellular carcinoma cells. Int. J. Mol. Med. 17 : 245 252.
10. Bae, S.H., E.S. Jung, Y.M. Park, et al. 2001. Expression of cyclooxigenase-2 (COX-2) in hepatocellular carcinoma and growth inhibition of hepatoma cells by a cyclooxygenase-2 inhibitor, NS-398. Clin. Cancer Res. 7 : 1410 1418.
11. Rahman, M.A., D.K. Dhar, E. Yamaguchi, et al. 2001 Coexpression of inducible nitric oxide synthase and COX-2 in hepatocellular carcinoma and surrounding liver: Possible involvement of COX-2 in angiogenesis of hepatitis C virus-positive cases. Clin. Cancer Res. 7 : 1325 1332.
12. Foderà, D., N. D'Alessandro, A. Cusimano, et al. 2004. Induction of apoptosis and inhibition of cell growth in human hepatocellular carcinoma cells by COX-2 inhibitors. Ann. N. Y. Acad. Sci. 1028 : 440 449.
13. Hu, K.Q., C.H. Yu, Y. Mineyama, et al. 2003. Inhibited proliferation of cyclooxygenase-2 expressing human hepatoma cells by NS-398, a selective COX-2 inhibitor. Int. J. Oncol. 22 : 757 763.
14. Cusimano, A., D. Foderà, N. D'Alessandro, et al. 2007. Potentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatic cancer cells by inhibition of the MEK/ERK pathway. Cancer Biol. Ther. 6 : 1461 1468.
15. Majima, M., H. Amano & I. Hayashi. 2003. Prostanoid receptor signaling relevant to tumor growth and angiogenesis. Trends Pharmacol. Sci. 24 : 524 529.
16. Dorsam, R.T. & J.S. Gutkind. 2007. G-protein-coupled receptors and cancer. Nat. Rev. Cancer 7 : 79 94.
17. Niho, N., M. Mutoh, T. Kitamura, et al. 2005. Suppression of azoxymethane-induced colon cancer development in rats by a prostaglandin E receptor EP1-selective antagonist. Cancer Sci. 96 : 260 264.
18. Makita, H., M. Mutoh, T. Maruyama, et al. 2007. A prostaglandin E2 receptor subtype EP1-selective antagonist, ONO-8711, suppresses 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis. Carcinogenesis 28 : 677 684.
19. Tober, K.L., T.A. Wilgus, D.F. Kusewitt, et al. 2006. Importance of the EP(1) receptor in cutaneous UVB-induced inflammation and tumor development. J. Invest. Dermatol. 126 : 205 211.
20. Han, C., G.K. Michalopoulos & T. Wu. 2006. Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells. J. Cell Physiol. 207 : 261 270.
21. Fujino, H., K.A. West & J.W. Regan. 2002. Phosphorylation of glycogen synthase kinase-3 and stimulation of T-cell factor signaling following activation of EP2 and EP4 prostanoid receptors by prostaglandin E2. J. Biol. Chem. 277 : 2614 2619.
22. Shao, J., S.B. Lee, H. Guo, et al. 2003. Prostaglandin E2 stimulates the growth of colon cancer cells via induction of amphiregulin. Cancer Res. 63 : 5218 5223.
23. Shoji, Y., M. Takahashi, T. Kitamura, et al. 2004. Downregulation of prostaglandin E receptor subtype EP3 during colon cancer development. Gut 53 : 1151 1158.
24. Cervello, M., L. Giannitrapani, M. La Rosa M, et al. 2002. Expression of HIP/PAP mRNA in human hepatoma cell lines. Ann. N. Y. Acad. Sci. 963 : 53 58.
25. Hull, M.A., S.C.W. Ko & G. Hawcroft. 2004. Prostaglandin EP receptors: Targets for treatment and prevention of colorectal cancer? Mol. Cancer Ther. 3 : 1031 1039.
26. Breinig, M., R. Rieker, E. Eiteneuer, et al. 2008. Differential expression of E-prostanoid receptors in human hepatocellular carcinoma. Int. J. Cancer 122 : 547 557.