Altered small-bowel mucosal vascular network in untreated coeliac disease

Scandinavian Journal of Gastroenterology

Volumn 44, Issue 2, 2009, Pages 162-167

  Myrsky, Essi ^a,b   Syrjänen, Mari ^a,b   Korponay Szabo, Ilma R ^c,d   Mäki, Markku ^a,b   Kaukinen, Katri ^a,b   Lindfors, Katri ^a,b  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c HEIM PÁL CHILDREN S HOSPITAL   (Hungary)

^d UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Autoantibodies; Coeliac disease; Gluten; Intestinal mucosa; Microvasculature; Transglutaminase 2

Indexed keywords

ACTIN ANTIBODY; ALPHA SMOOTH MUSCLE ACTIN; GLUTEN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE ANTIBODY;

ADULT; AGED; ARTICLE; BLOOD VESSEL WALL; CELIAC DISEASE; CONTROLLED STUDY; DUODENUM BIOPSY; DUODENUM MUCOSA; GLUTEN FREE DIET; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; INGESTION; MICROVASCULATURE; MORPHOMETRICS; PRIORITY JOURNAL;

ADULT; AGED; AUTOANTIBODIES; CELIAC DISEASE; DIET, GLUTEN-FREE; FEMALE; GLUTENS; GTP-BINDING PROTEINS; HUMANS; INTESTINAL MUCOSA; INTESTINE, SMALL; MALE; MICROVESSELS; MIDDLE AGED; NEOVASCULARIZATION, PHYSIOLOGIC; TRANSGLUTAMINASES;

EID: 61649110965     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.1080/00365520802400875     Document Type: Article

References (27)

1. Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO, et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med 1997;3:797-801.
2. Halttunen T, Maki M. Serum immunoglobulin A from patients with celiac disease inhibits human T84 intestinal crypt epithelial cell differentiation. Gastroenterology 1999;116:566-72.
3. Zanoni G, Navone R, Lunardi C, Tridente G, Bason C, Sivori S, et al. In celiac disease, a subset of autoantibodies against transglutaminase binds Toll-like receptor 4 and induces activation of monocytes. PLoS Med 2006;3:e358.
4. Barone MV, Caputo I, Ribecco MT, Maglio M, Marzari R, Sblattero D, et al. Humoral immune response to tissue transglutaminase is related to epithelial cell proliferation in celiac disease. Gastroenterology 2007;132:1245-53.
5. Boscolo S, Sarich A, Lorenzon A, Passoni M, Rui V, Stebel M, et al. Gluten ataxia: passive transfer in a mouse model. Ann NY Acad Sci 2007;1107:319-28.
6. Marzari R, Sblattero D, Florian F, Tongiorgi E, Not T, Tommasini A, et al. Molecular dissection of the tissue transglutaminase autoantibody response in celiac disease. J Immunol 2001;166:4170-6.
7. Korponay-Szabó IR, Halttunen T, Szalai Z, Laurila K, Király R, Kovács JB, et al. In vivo targeting of intestinal and extraintestinal transglutaminase 2 by coeliac autoantibodies. Gut 2004;53:641-8.
8. Kaukinen K, Peräaho M, Collin P, Partanen J, Woolley N, Kaartinen T, et al. Small-bowel mucosal transglutaminase 2-specific IgA deposits in coeliac disease without villous atrophy: a prospective and randomized clinical study. Scand J Gastroenterol 2005;40:564-72.
9. Salmi TT, Collin P, Järvinen O, Haimila K, Partanen J, Laurila K, et al. Immunoglobulin A autoantibodies against transglutaminase 2 in the small intestinal mucosa predict forthcoming coeliac disease. Aliment Pharmacol Ther 2006;24:541-52.
10. Salmi TT, Collin P, Korponay-Szabó IR, Laurila K, Partanen J, Huhtala H, et al. Endomysial antibody-negative coeliac disease: clinical characteristics and intestinal autoantibody deposits. Gut 2006;55:1746-53.
11. Hadjivassiliou M, Mäki M, Sanders DS, Williamson CA, Grünewald RA, Woodroofe NM, et al. Autoantibody targeting of brain and intestinal transglutaminase in gluten ataxia. Neurology 2006;66:373-7.
12. Yamada T, Alpers DH, Laine LMD, Kaplowitz NMD. Textbook of gastroenterology. Philadelphia: Lippincott Williams & Wilkins; 2003. pp 498-9.
13. Cooke WT, Holmes GKT. Coeliac disease. London: Churchill Livingstone; 1984. pp 27-8.
14. Shiner M, Ballard J. Antigen-antibody reactions in jejunal mucosa in childhood coeliac disease after gluten challenge. Lancet 1972;1:1202-5.
15. Shiner M. Ultrastructural changes suggestive of immune reactions in the jejunal mucosa of coeliac children following gluten challenge. Gut 1973;14:1-12.
16. Myrsky E, Kaukinen K, Syrjänen M, Korponay-Szabó IR, Mäki M, Lindfors K. Coeliac disease-specific autoantibodies targeted against transglutaminase 2 disturb angiogenesis. Clin Exp Immunol 2008;152:111-9.
17. Sehested M, Hou-Jensen K. Factor VII related antigen as an endothelial cell marker in benign and malignant diseases. Virchows Arch A Pathol Anat Histol 1981;391:217-25.
18. Skalli O, Ropraz P, Trzeciak A, Benzonana G, Gillessen D, Gabbiani G. A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation. J Cell Biol 1986;103:2787-96.
19. Kale S, Hanai J, Chan B, Karihaloo A, Grotendorst G, Cantley L, et al. Microarray analysis of in vitro pericyte differentiation reveals an angiogenic program of gene expression. FASEB J 2005;19:270-1.
20. Birckbichler PJ, Upchurch HF, Patterson MK Jr, Conway E. A monoclonal antibody to cellular transglutaminase. Hybridoma 1985;4:179-86.
21. Cario E, Podolsky DK. Differential alteration in intestinal epithelial cell expression of Toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect Immun 2000;68:7010-7.
22. Haroon ZA, Hettasch JM, Lai TS, Dewhirst MW, Greenberg CS. Tissue transglutaminase is expressed, active, and directly involved in rat dermal wound healing and angiogenesis. FASEB J 1999;13:1787-95.
23. Shepro D, Morel NM. Pericyte physiology. FASEB J 1993;7:1031-8.
24. Sturgess RP, Macartney JC, Makgoba MW, Hung CH, Haskard DO, Ciclitira PJ. Differential upregulation of intercellular adhesion molecule-1 in coeliac disease. Clin ExpImmunol 1990;82:489-92.
25. Ensari A, Ager A, Marsh MN, Morgan S, Moriarty KJ. Time-course of adhesion molecule expression in rectal mucosa of gluten-sensitive subjects after gluten challenge. Clin Exp Immunol 1993;92:303-7.
26. Maiuri L, Picarelli A, Boirivant M, Coletta S, Mazzilli MC, De Vincenzi M, et al. Definition of the initial immunologic modifications upon in vitro gliadin challenge in the small intestine of celiac patients. Gastroenterology 1996;110:1368-78.
27. Feng GM, Yang WG, Huan-Tang Chen S, Chu YM, Tsai LM, Chang TM, et al. Periodic alterations of jejunal mucosa morphology following free microvascular transfer for pharyngoesophageal reconstruction. J Plast Reconstr Aesthet Surg 2006;59:1312-7.