메뉴 건너뛰기




Volumn 15, Issue 3, 2009, Pages 149-154

Androgen receptor's destiny in mammalian oocytes: A new hypothesis

Author keywords

Androgen receptor; Meiosis; Ovary

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; GONADOTROPIN;

EID: 61649103319     PISSN: 13609947     EISSN: 14602407     Source Type: Journal    
DOI: 10.1093/molehr/gap006     Document Type: Review
Times cited : (34)

References (62)
  • 1
    • 21244500111 scopus 로고    scopus 로고
    • Androgen excess fetal programming of female reproduction: A developmental aetiology for polycystic ovary syndrome?
    • Abbott DH, Barnett DK, Bruns CM, Dumesic DA. Androgen excess fetal programming of female reproduction: A developmental aetiology for polycystic ovary syndrome? Hum Reprod Update 2005;11:357-374.
    • (2005) Hum Reprod Update , vol.11 , pp. 357-374
    • Abbott, D.H.1    Barnett, D.K.2    Bruns, C.M.3    Dumesic, D.A.4
  • 2
    • 33646543761 scopus 로고    scopus 로고
    • Contributions of androgen and estrogen to fetal programming of ovarian dysfunction
    • Abbott DH, Padmanabhan V, Dumesic DA. Contributions of androgen and estrogen to fetal programming of ovarian dysfunction. Reprod Biol Endocrinol 2006;4:17.
    • (2006) Reprod Biol Endocrinol , vol.4 , pp. 17
    • Abbott, D.H.1    Padmanabhan, V.2    Dumesic, D.A.3
  • 3
    • 0028851588 scopus 로고
    • The effect of testosterone on the maturation and developmental capacity of murine oocytes in vitro
    • Anderiesz C, Trounson AO. The effect of testosterone on the maturation and developmental capacity of murine oocytes in vitro. Hum Reprod 1995;10:2377-2381.
    • (1995) Hum Reprod , vol.10 , pp. 2377-2381
    • Anderiesz, C.1    Trounson, A.O.2
  • 4
    • 0036211567 scopus 로고    scopus 로고
    • Androgen receptor and follicle-stimulating hormone receptor in the pig ovary during the follicular phase of the estrous cycle
    • Cardenas H, Pope WF. Androgen receptor and follicle-stimulating hormone receptor in the pig ovary during the follicular phase of the estrous cycle. Mol Reprod Dev 2002;62:92-98.
    • (2002) Mol Reprod Dev , vol.62 , pp. 92-98
    • Cardenas, H.1    Pope, W.F.2
  • 5
    • 14844353662 scopus 로고    scopus 로고
    • Rapid actions of steroid receptors in cellular signaling pathways
    • Cato AC, Nestl A, Mink S. Rapid actions of steroid receptors in cellular signaling pathways. Sci STKE 2002;2002:RE9.
    • (2002) Sci STKE , vol.2002
    • Cato, A.C.1    Nestl, A.2    Mink, S.3
  • 8
    • 0013937480 scopus 로고
    • Action of actinomycin and puromycin upon frog oocyte maturation
    • Dettlaff TA. Action of actinomycin and puromycin upon frog oocyte maturation. J Embryol Exp Morphol 1966;16:183-195.
    • (1966) J Embryol Exp Morphol , vol.16 , pp. 183-195
    • Dettlaff, T.A.1
  • 9
    • 33646708559 scopus 로고    scopus 로고
    • The role of steroids in follicular growth
    • Drummond AE. The role of steroids in follicular growth. Reprod Biol Endocrinol 2006;4:16.
    • (2006) Reprod Biol Endocrinol , vol.4 , pp. 16
    • Drummond, A.E.1
  • 10
    • 15444366255 scopus 로고    scopus 로고
    • Polycystic ovary syndrome
    • Ehrmann DA. Polycystic ovary syndrome. N Engl J Med 2005;352 1223-1236.
    • (2005) N Engl J Med , vol.352 , pp. 1223-1236
    • Ehrmann, D.A.1
  • 11
    • 0025719359 scopus 로고
    • Maintenance of meiotic arrest and the induction of oocyte maturation in mouse oocyte-granulosa cell complexes developed in vitro from preantral follicles
    • Eppig JJ. Maintenance of meiotic arrest and the induction of oocyte maturation in mouse oocyte-granulosa cell complexes developed in vitro from preantral follicles. Biol Reprod 1991;45 824-830.
    • (1991) Biol Reprod , vol.45 , pp. 824-830
    • Eppig, J.J.1
  • 12
    • 0021090812 scopus 로고
    • Inhibition of oocyte maturation in the mouse: Participation of cAMP, steroid hormones, and a putative maturation-inhibitory factor
    • Eppig JJ, Freter RR, Ward-Bailey PF, Schultz RM. Inhibition of oocyte maturation in the mouse: Participation of cAMP, steroid hormones, and a putative maturation-inhibitory factor. Dev Biol 1983;100 39-49.
    • (1983) Dev Biol , vol.100 , pp. 39-49
    • Eppig, J.J.1    Freter, R.R.2    Ward-Bailey, P.F.3    Schultz, R.M.4
  • 13
    • 0027184473 scopus 로고
    • Requirement for Raf and MAP kinase function during the meiotic maturation of Xenopus oocytes
    • Fabian JR, Morrison DK, Daar IO. Requirement for Raf and MAP kinase function during the meiotic maturation of Xenopus oocytes. J Cell Biol 1993;122:645-652.
    • (1993) J Cell Biol , vol.122 , pp. 645-652
    • Fabian, J.R.1    Morrison, D.K.2    Daar, I.O.3
  • 14
    • 1242321328 scopus 로고    scopus 로고
    • Involvement of mitogen-activated protein kinase cascade during oocyte maturation and fertilization in mammals
    • Fan HY, Sun QY. Involvement of mitogen-activated protein kinase cascade during oocyte maturation and fertilization in mammals. Biol Reprod 2004; 70:535-547.
    • (2004) Biol Reprod , vol.70 , pp. 535-547
    • Fan, H.Y.1    Sun, Q.Y.2
  • 15
    • 0346656465 scopus 로고    scopus 로고
    • Androgens promote maturation and signaling in mouse oocytes independent of transcription: A release of inhibition model for mammalian oocyte meiosis
    • Gill A, Jamnongjit M, Hammes SR. Androgens promote maturation and signaling in mouse oocytes independent of transcription: A release of inhibition model for mammalian oocyte meiosis. Mol Endocrinol 2004; 18:97-104.
    • (2004) Mol Endocrinol , vol.18 , pp. 97-104
    • Gill, A.1    Jamnongjit, M.2    Hammes, S.R.3
  • 16
    • 1842584190 scopus 로고    scopus 로고
    • Steroids and oocyte maturation - a new look at an old story
    • Hammes SR. Steroids and oocyte maturation - a new look at an old story. Mol Endocrinol 2004;18:769-775.
    • (2004) Mol Endocrinol , vol.18 , pp. 769-775
    • Hammes, S.R.1
  • 18
    • 0036219918 scopus 로고    scopus 로고
    • Androgen receptor (AR) coregulators: An overview
    • Heinlein CA, Chang C. Androgen receptor (AR) coregulators: An overview. Endocr Rev 2002;23:175-200.
    • (2002) Endocr Rev , vol.23 , pp. 175-200
    • Heinlein, C.A.1    Chang, C.2
  • 21
    • 33744933179 scopus 로고    scopus 로고
    • Ovarian steroids: The good, the bad, and the signals that raise them
    • Jamnongjit M, Hammes SR. Ovarian steroids: The good, the bad, and the signals that raise them. Cell Cycle 2006;5:1178-1183.
    • (2006) Cell Cycle , vol.5 , pp. 1178-1183
    • Jamnongjit, M.1    Hammes, S.R.2
  • 22
    • 28044467986 scopus 로고    scopus 로고
    • Epidermal growth factor receptor signaling is required for normal ovarian steroidogenesis and oocyte maturation
    • Jamnongjit M, Gill A, Hammes SR. Epidermal growth factor receptor signaling is required for normal ovarian steroidogenesis and oocyte maturation. Proc Natl Acad Sci USA 2005;102:16257-16262.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 16257-16262
    • Jamnongjit, M.1    Gill, A.2    Hammes, S.R.3
  • 23
    • 32544434075 scopus 로고    scopus 로고
    • Oestrogen receptor alpha and beta, androgen receptor and progesterone receptor mRNA and protein localisation within the developing ovary and in small growing follicles of sheep
    • Juengel JL, Heath DA, Quirke LD, McNatty KP. Oestrogen receptor alpha and beta, androgen receptor and progesterone receptor mRNA and protein localisation within the developing ovary and in small growing follicles of sheep. Reproduction 2006;131:81-92.
    • (2006) Reproduction , vol.131 , pp. 81-92
    • Juengel, J.L.1    Heath, D.A.2    Quirke, L.D.3    McNatty, K.P.4
  • 24
    • 0029664457 scopus 로고    scopus 로고
    • Activation of p90rsk during meiotic maturation and first mitosis in mouse oocytes and eggs: MAP kinase-independent and -dependent activation
    • Kalab P, Kubiak JZ, Verlhac MH, Colledge WH, Maro B. Activation of p90rsk during meiotic maturation and first mitosis in mouse oocytes and eggs: MAP kinase-independent and -dependent activation. Development 1996;122:1957-1964.
    • (1996) Development , vol.122 , pp. 1957-1964
    • Kalab, P.1    Kubiak, J.Z.2    Verlhac, M.H.3    Colledge, W.H.4    Maro, B.5
  • 26
    • 55549140807 scopus 로고    scopus 로고
    • Testosterone potentially triggers meiotic resumption by activation of intra-oocyte SRC and MAPK in porcine oocytes
    • Li M, Ai JS, Xu BZ, Xiong B, Yin S, Lin SL, Hou Y, Chen DY, Schatten H, Sun QY. Testosterone potentially triggers meiotic resumption by activation of intra-oocyte SRC and MAPK in porcine oocytes. Biol Reprod 2008a;79:897-905.
    • (2008) Biol Reprod , vol.79 , pp. 897-905
    • Li, M.1    Ai, J.S.2    Xu, B.Z.3    Xiong, B.4    Yin, S.5    Lin, S.L.6    Hou, Y.7    Chen, D.Y.8    Schatten, H.9    Sun, Q.Y.10
  • 27
    • 42649120149 scopus 로고    scopus 로고
    • PI3-kinase and mitogen-activated protein kinase in cumulus cells mediate EGF-induced meiotic resumption of porcine oocyte
    • Li M, Liang CG, Xiong B, Xu BZ, Lin SL, Hou Y, Chen DY, Schatten H, Sun QY. PI3-kinase and mitogen-activated protein kinase in cumulus cells mediate EGF-induced meiotic resumption of porcine oocyte. Domest Anim Endocrinol 2008b;34:360-371.
    • (2008) Domest Anim Endocrinol , vol.34 , pp. 360-371
    • Li, M.1    Liang, C.G.2    Xiong, B.3    Xu, B.Z.4    Lin, S.L.5    Hou, Y.6    Chen, D.Y.7    Schatten, H.8    Sun, Q.Y.9
  • 28
    • 34548304288 scopus 로고    scopus 로고
    • Mechanisms regulating oocyte meiotic resumption: Roles of mitogen-activated protein kinase
    • Liang CG, Su YQ, Fan HY, Schatten H, Sun QY. Mechanisms regulating oocyte meiotic resumption: Roles of mitogen-activated protein kinase. Mol Endocrinol 2007;21:2037-2055.
    • (2007) Mol Endocrinol , vol.21 , pp. 2037-2055
    • Liang, C.G.1    Su, Y.Q.2    Fan, H.Y.3    Schatten, H.4    Sun, Q.Y.5
  • 31
    • 0035923642 scopus 로고    scopus 로고
    • Evidence that androgens are the primary steroids produced by Xenopus laevis ovaries and may signal through the classical androgen receptor to promote oocyte maturation
    • Lutz LB, Cole LM, Gupta MK, Kwist KW, Auchus RJ, Hammes SR. Evidence that androgens are the primary steroids produced by Xenopus laevis ovaries and may signal through the classical androgen receptor to promote oocyte maturation. Proc Natl Acad Sci USA 2001;98 13728-13733.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 13728-13733
    • Lutz, L.B.1    Cole, L.M.2    Gupta, M.K.3    Kwist, K.W.4    Auchus, R.J.5    Hammes, S.R.6
  • 32
    • 0016187921 scopus 로고
    • Evidence from Tfm-O that androgen is inessential for reproduction in female mice
    • Lyon MF, Glenister PH. Evidence from Tfm-O that androgen is inessential for reproduction in female mice. Nature 1974;247:366-367.
    • (1974) Nature , vol.247 , pp. 366-367
    • Lyon, M.F.1    Glenister, P.H.2
  • 34
    • 34548060044 scopus 로고    scopus 로고
    • Are steroids obligatory mediators of luteinizing hormone/human chorionic gonadotropin-triggered resumption of meiosis in mammals?
    • Motola S, Popliker M, Tsafriri A. Are steroids obligatory mediators of luteinizing hormone/human chorionic gonadotropin-triggered resumption of meiosis in mammals? Endocrinology 2007;148:4458-4465.
    • (2007) Endocrinology , vol.148 , pp. 4458-4465
    • Motola, S.1    Popliker, M.2    Tsafriri, A.3
  • 35
    • 0031877054 scopus 로고    scopus 로고
    • Effect of androgens on the development of mouse follicles growing in vitro
    • Murray AA, Gosden RG, Allison V, Spears N. Effect of androgens on the development of mouse follicles growing in vitro. J Reprod Fertil 1998; 113:27-33.
    • (1998) J Reprod Fertil , vol.113 , pp. 27-33
    • Murray, A.A.1    Gosden, R.G.2    Allison, V.3    Spears, N.4
  • 36
    • 0037306812 scopus 로고    scopus 로고
    • Analyses of mitogen-activated protein kinase function in the maturation of porcine oocytes
    • Ohashi S, Naito K, Sugiura K, Iwamori N, Goto S, Naruoka H, Tojo H. Analyses of mitogen-activated protein kinase function in the maturation of porcine oocytes. Biol Reprod 2003;68:604-609.
    • (2003) Biol Reprod , vol.68 , pp. 604-609
    • Ohashi, S.1    Naito, K.2    Sugiura, K.3    Iwamori, N.4    Goto, S.5    Naruoka, H.6    Tojo, H.7
  • 38
    • 0020664908 scopus 로고
    • Regulation of oocyte maturation in the mouse: Possible roles of intercellular communication, cAMP, and testosterone
    • Schultz RM, Montgomery RR, Ward-Bailey PF, Eppig JJ. Regulation of oocyte maturation in the mouse: Possible roles of intercellular communication, cAMP, and testosterone. Dev Biol 1983;95 294-304.
    • (1983) Dev Biol , vol.95 , pp. 294-304
    • Schultz, R.M.1    Montgomery, R.R.2    Ward-Bailey, P.F.3    Eppig, J.J.4
  • 41
    • 0033771003 scopus 로고    scopus 로고
    • Role of aromatase in sex steroid action
    • Simpson ER. Role of aromatase in sex steroid action. J Mol Endocrinol 2000; 25:149-156.
    • (2000) J Mol Endocrinol , vol.25 , pp. 149-156
    • Simpson, E.R.1
  • 42
    • 0035150932 scopus 로고    scopus 로고
    • The expression of androgen receptor, cytochrome P450 aromatase and FSH receptor mRNA in the porcine ovary
    • Slomczynska M, Duda M, Sl zak K. The expression of androgen receptor, cytochrome P450 aromatase and FSH receptor mRNA in the porcine ovary. Folia Histochem Cytobiol 2001;39:9-13.
    • (2001) Folia Histochem Cytobiol , vol.39 , pp. 9-13
    • Slomczynska, M.1    Duda, M.2    Sl zak, K.3
  • 43
    • 0015080763 scopus 로고
    • The interaction of steroids with Rana pipiens oocytes in the induction of maturation
    • Smith LD, Ecker RE. The interaction of steroids with Rana pipiens oocytes in the induction of maturation. Dev Biol 1971;25 232-247.
    • (1971) Dev Biol , vol.25 , pp. 232-247
    • Smith, L.D.1    Ecker, R.E.2
  • 44
    • 0019120937 scopus 로고
    • Effects of steroids on mouse oocyte maturation in vitro
    • Smith DM, Tenney DY. Effects of steroids on mouse oocyte maturation in vitro. J Reprod Fertil 1980;60:331-338.
    • (1980) J Reprod Fertil , vol.60 , pp. 331-338
    • Smith, D.M.1    Tenney, D.Y.2
  • 45
    • 0014297396 scopus 로고
    • In vitro induction of physiological maturation in Rana pipiens oocytes removed from their ovarian follicles
    • Smith LD, Ecker RE, Subtelny S. In vitro induction of physiological maturation in Rana pipiens oocytes removed from their ovarian follicles. Dev Biol 1968;17:627-643.
    • (1968) Dev Biol , vol.17 , pp. 627-643
    • Smith, L.D.1    Ecker, R.E.2    Subtelny, S.3
  • 46
    • 0036090432 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase activity in cumulus cells is essential for gonadotropin-induced oocyte meiotic resumption and cumulus expansion in the mouse
    • Su YQ, Wigglesworth K, Pendola FL, O'Brien MJ, Eppig JJ. Mitogen-activated protein kinase activity in cumulus cells is essential for gonadotropin-induced oocyte meiotic resumption and cumulus expansion in the mouse. Endocrinology 2002;143:2221-2232.
    • (2002) Endocrinology , vol.143 , pp. 2221-2232
    • Su, Y.Q.1    Wigglesworth, K.2    Pendola, F.L.3    O'Brien, M.J.4    Eppig, J.J.5
  • 47
    • 0142042874 scopus 로고    scopus 로고
    • Oocyte-dependent activation of mitogen-activated protein kinase (ERK1/2) in cumulus cells is required for the maturation of the mouse oocyte-cumulus cell complex
    • Su YQ, Denegre JM, Wigglesworth K, Pendola FL, O'Brien MJ, Eppig JJ. Oocyte-dependent activation of mitogen-activated protein kinase (ERK1/2) in cumulus cells is required for the maturation of the mouse oocyte-cumulus cell complex. Dev Biol 2003;263:126-138.
    • (2003) Dev Biol , vol.263 , pp. 126-138
    • Su, Y.Q.1    Denegre, J.M.2    Wigglesworth, K.3    Pendola, F.L.4    O'Brien, M.J.5    Eppig, J.J.6
  • 48
    • 0027977836 scopus 로고
    • Immunohistochemical distribution of progesterone, androgen and oestrogen receptors in the human ovary during the menstrual cycle: Relationship to expression of steroidogenic enzymes
    • Suzuki T, Sasano H, Kimura N, Tamura M, Fukaya T, Yajima A, Nagura H. Immunohistochemical distribution of progesterone, androgen and oestrogen receptors in the human ovary during the menstrual cycle: Relationship to expression of steroidogenic enzymes. Hum Reprod 1994;9 1589-1595.
    • (1994) Hum Reprod , vol.9 , pp. 1589-1595
    • Suzuki, T.1    Sasano, H.2    Kimura, N.3    Tamura, M.4    Fukaya, T.5    Yajima, A.6    Nagura, H.7
  • 49
    • 0029767472 scopus 로고    scopus 로고
    • Androgen receptor gene expression in rat granulosa cells: The role of follicle-stimulating hormone and steroid hormones
    • Tetsuka M, Hillier SG. Androgen receptor gene expression in rat granulosa cells: The role of follicle-stimulating hormone and steroid hormones. Endocrinology 1996;137:4392-4397.
    • (1996) Endocrinology , vol.137 , pp. 4392-4397
    • Tetsuka, M.1    Hillier, S.G.2
  • 51
    • 34948835205 scopus 로고    scopus 로고
    • Are steroids dispensable for meiotic resumption in mammals?
    • Tsafriri A, Motola S. Are steroids dispensable for meiotic resumption in mammals? Trends Endocrinol Metab 2007;18:321-327.
    • (2007) Trends Endocrinol Metab , vol.18 , pp. 321-327
    • Tsafriri, A.1    Motola, S.2
  • 52
    • 0032525901 scopus 로고    scopus 로고
    • Androgens stimulate early stages of follicular growth in the primate ovary
    • Vendola KA, Zhou J, Adesanya OO, Weil SJ, Bondy CA. Androgens stimulate early stages of follicular growth in the primate ovary. J Clin Invest 1998;101:2622-2629.
    • (1998) J Clin Invest , vol.101 , pp. 2622-2629
    • Vendola, K.A.1    Zhou, J.2    Adesanya, O.O.3    Weil, S.J.4    Bondy, C.A.5
  • 53
    • 0016249436 scopus 로고
    • Relationship between maturation division, ovulation and leuteinization in the female rat
    • Vermeiden JP, Zeilmaker GH. Relationship between maturation division, ovulation and leuteinization in the female rat. Endocrinology 1974; 95:341-351.
    • (1974) Endocrinology , vol.95 , pp. 341-351
    • Vermeiden, J.P.1    Zeilmaker, G.H.2
  • 54
    • 34547093857 scopus 로고    scopus 로고
    • Female mice haploinsufficient for an inactivated androgen receptor (AR) exhibit age-dependent defects that resemble the AR null phenotype of dysfunctional late follicle development, ovulation, and fertility
    • Walters KA, Allan CM, Jimenez M, Lim PR, Davey RA, Zajac JD, Illingworth P, Handelsman DJ. Female mice haploinsufficient for an inactivated androgen receptor (AR) exhibit age-dependent defects that resemble the AR null phenotype of dysfunctional late follicle development, ovulation, and fertility. Endocrinology 2007;148:3674-3684.
    • (2007) Endocrinology , vol.148 , pp. 3674-3684
    • Walters, K.A.1    Allan, C.M.2    Jimenez, M.3    Lim, P.R.4    Davey, R.A.5    Zajac, J.D.6    Illingworth, P.7    Handelsman, D.J.8
  • 57
    • 0031757965 scopus 로고    scopus 로고
    • Androgen receptor gene expression in the primate ovary: Cellular localization, regulation, and functional correlations
    • Weil SJ, Vendola K, Zhou J, Adesanya OO, Wang J, Okafor J, Bondy CA. Androgen receptor gene expression in the primate ovary: Cellular localization, regulation, and functional correlations. J Clin Endocrinol Metab 1998;83:2479-2485.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2479-2485
    • Weil, S.J.1    Vendola, K.2    Zhou, J.3    Adesanya, O.O.4    Wang, J.5    Okafor, J.6    Bondy, C.A.7
  • 58
    • 0036288282 scopus 로고    scopus 로고
    • Wood JR, Strauss JF 3rd. Multiple signal transduction pathways regulate ovarian steroidogenesis. Rev Endocr Metab Disord 2002;3 33-46.
    • Wood JR, Strauss JF 3rd. Multiple signal transduction pathways regulate ovarian steroidogenesis. Rev Endocr Metab Disord 2002;3 33-46.
  • 59
    • 33846948960 scopus 로고    scopus 로고
    • Wood JR, Dumesic DA, Abbott DH, Strauss JF 3rd. Molecular abnormalities in oocytes from women with polycystic ovary syndrome revealed by microarray analysis. J Clin Endocrinol Metab 2007;92:705-713.
    • Wood JR, Dumesic DA, Abbott DH, Strauss JF 3rd. Molecular abnormalities in oocytes from women with polycystic ovary syndrome revealed by microarray analysis. J Clin Endocrinol Metab 2007;92:705-713.
  • 60
    • 33751574488 scopus 로고    scopus 로고
    • Testosterone stimulates the primary to secondary follicle transition in bovine follicles in vitro
    • Yang MY, Fortune JE. Testosterone stimulates the primary to secondary follicle transition in bovine follicles in vitro. Biol Reprod 2006; 75:924-932.
    • (2006) Biol Reprod , vol.75 , pp. 924-932
    • Yang, M.Y.1    Fortune, J.E.2
  • 61
    • 0038439208 scopus 로고    scopus 로고
    • Xenopus laevis ovarian CYP17 is a highly potent enzyme expressed exclusively in oocytes. Evidence that oocytes play a critical role in Xenopus ovarian androgen production
    • Yang WH, Lutz LB, Hammes SR. Xenopus laevis ovarian CYP17 is a highly potent enzyme expressed exclusively in oocytes. Evidence that oocytes play a critical role in Xenopus ovarian androgen production. J Biol Chem 2003;278:9552-9559.
    • (2003) J Biol Chem , vol.278 , pp. 9552-9559
    • Yang, W.H.1    Lutz, L.B.2    Hammes, S.R.3
  • 62
    • 0037108766 scopus 로고    scopus 로고
    • Generation and characterization of androgen receptor knockout (ARKO) mice: An in vivo model for the study of androgen functions in selective tissues
    • Yeh S, Tsai MY, Xu Q, Mu XM, Lardy H, Huang KE, Lin H, Yeh SD, Altuwaijri S, Zhou X et al. Generation and characterization of androgen receptor knockout (ARKO) mice: An in vivo model for the study of androgen functions in selective tissues. Proc Natl Acad Sci USA 2002;99:13498-13503.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13498-13503
    • Yeh, S.1    Tsai, M.Y.2    Xu, Q.3    Mu, X.M.4    Lardy, H.5    Huang, K.E.6    Lin, H.7    Yeh, S.D.8    Altuwaijri, S.9    Zhou, X.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.