Structural Basis for the Mutually Exclusive Anchoring of P Body Components EDC3 and Tral to the DEAD Box Protein DDX6/Me31B

Molecular Cell

Volumn 33, Issue 5, 2009, Pages 661-668

  Tritschler, Felix ^a   Braun, Joerg E ^a   Eulalio, Ana ^a   Truffault, Vincent ^a   Izaurralde, Elisa ^a   Weichenrieder, Oliver ^a  

^a MAX PLANCK INSTITUTE FOR DEVELOPMENTAL BIOLOGY   (Germany)

Author keywords

PROTEINS; RNA

Indexed keywords

ADENOSINE TRIPHOSPHATE; DEAD BOX PROTEIN; MESSENGER RNA; PROTEIN DDX6; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DIMERIZATION; DROSOPHILA MELANOGASTER; HUMAN; MUTAGENESIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN STRUCTURE; RNA BINDING; RNA SEQUENCE; RNA TRANSLATION;

ADENOSINE TRIPHOSPHATE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CLONING, MOLECULAR; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DEAD-BOX RNA HELICASES; DROSOPHILA PROTEINS; HUMANS; HYDROLYSIS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; RECOMBINANT PROTEINS; RIBONUCLEOPROTEINS; RIBONUCLEOPROTEINS, SMALL NUCLEAR; RNA, MESSENGER;

EID: 61649102918     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2009.02.014     Document Type: Article

References (26)

1. Albrecht M., and Lengauer T. Novel Sm-like proteins with long C-terminal tails and associated methyltransferases. FEBS Lett. 569 (2004) 18-26
2. Anantharaman V., and Aravind L. Novel conserved domains in proteins with predicted roles in eukaryotic cell-cycle regulation, decapping and RNA stability. BMC Genomics 5 (2004) 45
3. Andersen C.B., Ballut L., Johansen J.S., Chamieh H., Nielsen K.H., Oliveira C.L., Pedersen J.S., Séraphin B., Le Hir H., and Andersen G.R. Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA. Science 313 (2006) 1968-1972
4. Bono F., Ebert J., Lorentzen E., and Conti E. The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA. Cell 126 (2006) 713-725
5. Caruthers J.M., Johnson E.R., and McKay D.B. Crystal structure of yeast initiation factor 4A, a DEAD-box RNA helicase. Proc. Natl. Acad. Sci. USA 97 (2000) 13080-13085
6. Cheng Z., Coller J., Parker R., and Song H. Crystal structure and functional analysis of DEAD-box protein Dhh1p. RNA 11 (2005) 1258-1270
7. Chu C.Y., and Rana T.M. Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54. PLoS Biol. 4 (2006) e210 10.1371/journal.pbio.0040210
8. Coller J., and Parker R. General translational repression by activators of mRNA decapping. Cell 122 (2005) 875-886
9. Coller J.M., Tucker M., Sheth U., Valencia-Sanchez M.A., and Parker R. The DEAD box helicase, Dhh1p, functions in mRNA decapping and interacts with both the decapping and deadenylase complexes. RNA 7 (2001) 1717-1727
10. Decker C.J., Teixeira D., and Parker R. Edc3p and a glutamine/asparagine-rich domain of Lsm4p function in processing body assembly in Saccharomyces cerevisiae. J. Cell Biol. 179 (2007) 437-449
11. Dyson H.J., and Wright P.E. Intrinsically unstructured proteins and their functions. Nat. Rev. Mol. Cell Biol. 6 (2005) 197-208
12. Eulalio A., Rehwinkel J., Stricker M., Huntzinger E., Yang S.-F., Doerks T., Dorner S., Bork P., Boutros M., and Izaurralde E. A target-specific requirement for enhancers of decapping in miRNA-mediated gene silencing. Genes Dev. 21 (2007) 2558-2570
13. Fenger-Grøn M., Fillman C., Norrild B., and Lykke-Andersen J. Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. Mol. Cell 20 (2005) 905-915
14. Högbom M., Collins R., van den Berg S., Jenvert R.M., Karlberg T., Kotenyova T., Flores A., Karlsson Hedestam G.B., and Schiavone L.H. Crystal structure of conserved domains 1 and 2 of the human DEAD-box helicase DDX3X in complex with the mononucleotide AMP. J. Mol. Biol. 372 (2007) 150-159
15. Jankowsky E., and Bowers H. Remodeling of ribonucleoprotein complexes with DExH/D RNA helicases. Nucleic Acids Res. 34 (2006) 4181-4188
16. Linder P., and Lasko P. Bent out of shape: RNA unwinding by the DEAD-box helicase Vasa. Cell 125 (2006) 219-221
17. Ling S.H., Decker C.J., Walsh M.A., She M., Parker R., and Song H. Crystal structure of human Edc3 and its functional implications. Mol. Cell. Biol. 28 (2008) 5965-5976
18. Minshall N., and Standart N. The active form of Xp54 RNA helicase in translational repression is an RNA-mediated oligomer. Nucleic Acids Res. 32 (2004) 1325-1334
19. Minshall N., Thom G., and Standart N. A conserved role of a DEAD box helicase in mRNA masking. RNA 7 (2001) 1728-1742
20. Rehwinkel J., Behm-Ansmant I., Gatfield D., and Izaurralde E. A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing. RNA 11 (2005) 1640-1647
21. Sengoku T., Nureki O., Nakamura A., Kobayashi S., and Yokoyama S. Structural basis for RNA unwinding by the DEAD-box protein Drosophila Vasa. Cell 125 (2006) 287-300
22. Shi H., Cordin O., Minder C.M., Linder P., and Xu R.M. Crystal structure of the human ATP-dependent splicing and export factor UAP56. Proc. Natl. Acad. Sci. USA 101 (2004) 17628-17633
23. Tritschler F., Eulalio A., Truffault V., Hartmann M.D., Helms S., Schmidt S., Coles M., Izaurralde E., and Weichenrieder O. A divergent Sm-fold in EDC3 proteins mediates DCP1-binding and P-body targeting. Mol. Cell. Biol. 27 (2007) 8600-8611
24. Tritschler F., Eulalio A., Helms S., Schmidt S., Coles M., Weichenrieder O., Izaurralde E., and Truffault V. A similar mode of interaction enables Trailer Hitch and EDC3 to associate with DCP1 and Me31B in distinct protein complexes. Mol. Cell. Biol. 28 (2008) 6695-6708
25. Weston A., and Sommerville J. Xp54 and related (DDX6-like) RNA helicases: roles in messenger RNP assembly, translation regulation and RNA degradation. Nucleic Acids Res. 34 (2006) 3082-3094
26. Zhao R., Shen J., Green M.R., MacMorris M., and Blumenthal T. Crystal structure of UAP56, a DExD/H-box protein involved in pre-mRNA splicing and mRNA export. Structure 12 (2004) 1373-1381