Risk of sensitization in healthy adults following repeated administration of rdESAT-6 skin test reagent by the Mantoux injection technique

Tuberculosis

Volumn 89, Issue 2, 2009, Pages 158-162

  Lillebaek, Troels ^a   Bergstedt, Winnie ^a   Tingskov, Pernille N ^b   Thierry Carstensen, Birgit ^b   Aggerbeck, Henrik ^b   Hoff, Soeren T ^b   Weldingh, Karin ^b   Andersen, Peter ^b   Soborg, Bolette ^b   Thomsen, Vibeke O ^b   Andersen, Aase B ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b STATENS SERUM INSTITUT   (Denmark)

Author keywords

ESAT 6; Repeated administration; Safety; Sensitization; Skin test; Tuberculosis

Indexed keywords

BCG VACCINE; EARLY SECRETORY ANTIGENIC TARGET 6; GAMMA INTERFERON; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; ESAT-6 PROTEIN, MYCOBACTERIUM TUBERCULOSIS;

ADULT; ANUS FISSURE; ARTICLE; CAUSAL ATTRIBUTION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; DRUG SAFETY; FATIGUE; FEMALE; FEVER; HAY FEVER; HEADACHE; HUMAN; INJECTION SITE CONTUSION; INJECTION SITE NECROSIS; INJECTION SITE PAIN; INJECTION SITE REACTION; INJECTION SITE SWELLING; INJECTION SITE VESICLE; LYMPHADENITIS; MALE; MOUTH PAIN; MYALGIA; MYCOBACTERIUM TUBERCULOSIS; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RHINITIS; SINUSITIS; SKIN SENSITIZATION; SKIN TEST; SLEEP DISORDER; TUBERCULIN TEST; TUBERCULOSIS; ADOLESCENT; BIOSYNTHESIS; DIAGNOSTIC USE; HYPERSENSITIVITY, DELAYED; IMMUNOLOGY; INTRACUTANEOUS TEST; INTRADERMAL DRUG ADMINISTRATION; MIDDLE AGED; YOUNG ADULT;

ADOLESCENT; ADULT; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; FEMALE; HUMANS; HYPERSENSITIVITY, DELAYED; INJECTIONS, INTRADERMAL; INTERFERON-GAMMA; INTRADERMAL TESTS; MALE; MIDDLE AGED; TUBERCULOSIS; YOUNG ADULT;

EID: 61649098772     PISSN: 14729792     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tube.2008.09.007     Document Type: Article

References (14)

1. Madhukar P., Shriprakash K., and Keertan D. New tools and emerging technologies for the diagnosis of tuberculosis: Part 1. Latent tuberculosis. Expert Rev Mol Diagn 6 3 (2006) 413-422
2. Snider D.E. Tuberculin test. Am Rev Respir Dis 125 (1982) 108-118
3. Huebner R.E., Schein M.F., and Bass J.B. The tuberculin skin test. Clin Infect Dis 17 (1993) 968-975
4. Madhukar P., Riley L.W., and Colford Jr. J.M. Interferon-γ assays in the immunodiagnosis of tuberculosis: a systematic review. Lancet Infect Dis 4 (2004) 761-776
5. Arend S.M., Franken W.P.J., Aggerbeck H., Prins C., van Dissel J.T., Thierry-Carstensen B., et al. Double-blind randomized phase I study comparing rdESAT-6 to tuberculin as skin test reagent in the diagnosis of tuberculosis infection. Tuberculosis 88 (2007) 249-261
6. Ulrichs T., Munk M.E., Mollenkopf H., Behr-Perst S., Colangeli R., Gennaro M.L., et al. Differential T-cell responses to Mycobacterium tuberculosis ESAT-6 in tuberculosis patients and healthy donors. Eur J Immunol 28 (1998) 3949-3958
7. Ravn P., Demissie A., Eguale T., Wondwosson H., Lein D., Amoudy H.A., et al. Human T-cell responses to the ESAT-6 antigen from Mycobacterium tuberculosis. J Infect Dis 179 (1999) 637-645
8. Johnson P.D., Stuart R.L., Grayson M.L., Olden D., Clancy A., Ravn P., et al. Tuberculin-purified protein derivative-, MPT-64-, and ESAT-6-stimulated gamma interferon responses in medical students before and after Mycobacterium bovis BCG vaccination and in patients with tuberculosis. Clin Diagn Lab Immunol 6 (1999) 934-937
9. Lein A.D., von Revn C.F., Ravn P., Horsburgh Jr. C.R., Alexander L.N., and Andersen P. Cellular immune responses to ESAT-6 discriminate between patients with pulmonary disease due to Mycobacterium avium complex and those with pulmonary disease due to Mycobacterium tuberculosis. Clin Diagn Lab Immunol 6 (1999) 606-609
10. Andersen P., Munck M.E., Pollock J.M., and Doherty T.M. Specific immune-based diagnosis of tuberculosis. Lancet 356 (2000) 1099-1104
11. Elhay M.J., Oettinger T., and Andersen P. Delayed type hypersensitivity responses to ESAT-6 and MPT-64 from Mycobacterium tuberculosis in the guinea pig. Infect Immun 66 (1998) 3454-3456
12. Aggerbeck H., and Madsen S.M. Safety of ESAT-6. Tuberculosis 86 (2006) 363-373
13. Andersen P., Andersen A.B., Sorensen A.L., and Nagai S. Recall of long-lived immunity to Mycobacterium tuberculosis infection in mice. J Immunol 154 (1995) 3359-3372
14. Choi J.C., Shin J.W., Kim J.Y., Park I.W., Choi B.W., and Lee M.K. The effect of previous tuberculin skin test on the follow-up examination of whole-blood interferon-gamma assay in the screening for latent tuberculosis infection. Chest 133 6 (2008) 1415-1420