Fibrinogen-γ C-Terminal fragments induce endothelial barrier dysfunction and microvascular leak via integrin-mediated and RhoA-dependent mechanism

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 29, Issue 3, 2009, Pages 394-400

  Guo, Mingzhang ^a   Daines, Dayle ^a   Tang, Jing ^a   Shen, Qiang ^a   Perrin, Rachel M ^a   Takada, Yoshikazu ^a   Yuan, Sarah Y ^a   Wu, Mack H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Fibrinogen degradation products; Microvascular permeability; Rho GTPase; Signal transduction; Thrombosis

Indexed keywords

ALBUMIN; BETA3 INTEGRIN; EPTIFIBATIDE; FIBRINOGEN; FIBRINOGEN GAMMA; MYOSIN LIGHT CHAIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ALBUMINOID; AMIDE; FIBRINOGEN GAMMA (151 411); FIBRINOGEN GAMMA (151-411); PEPTIDE FRAGMENT; PROTEIN KINASE INHIBITOR; PYRIDINE DERIVATIVE; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ELECTRIC RESISTANCE; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVATION; ENZYME INHIBITION; HYDRAULIC CONDUCTIVITY; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IN VIVO STUDY; MICROSCOPY; MICROVASCULARIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRESS FIBER; WATER PERMEABILITY; ANIMAL; C57BL MOUSE; CAPILLARY PERMEABILITY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HUMAN; IMPEDANCE; METABOLISM; MICROCIRCULATION; MOUSE; MOUSE MUTANT; PATHOPHYSIOLOGY; PHOSPHORYLATION; PROTEIN BINDING; RAT; RNA INTERFERENCE; SPLANCHNIC BLOOD FLOW; SPRAGUE DAWLEY RAT; TIME; VASCULAR ENDOTHELIUM;

ALBUMINS; AMIDES; ANIMALS; CAPILLARY PERMEABILITY; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC IMPEDANCE; ENDOTHELIUM, VASCULAR; FIBRINOGEN; HUMANS; INTEGRIN ALPHAVBETA3; INTEGRIN BETA3; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROCIRCULATION; MICROSCOPY, VIDEO; MYOSIN LIGHT CHAINS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; RHOA GTP-BINDING PROTEIN; RNA INTERFERENCE; RNA, SMALL INTERFERING; SPLANCHNIC CIRCULATION; STRESS FIBERS; TIME FACTORS;

EID: 61549138382     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.108.180950     Document Type: Article

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