FR167653 improves renal recovery and decreases inflammation and fibrosis after renal ischemia reperfusion injury

Journal of Vascular Surgery

Volumn 49, Issue 3, 2009, Pages 728-740

  Cau, Jerome ^a,b   Favreau, Frederic ^a   Zhang, Keqiang ^e   Febrer, Guillaume ^a,b   de la Motte, Gilles Regnault ^a,b   Ricco, Jean Baptiste ^e   Goujon, Jean Michel ^a,c   Hauet, Thierry ^a,d  

^a UNIVERSITÉ DE POITIERS   (France)

^b Service de Chirurgie Vasculaire   (France)

^c POITIERS UNIVERSITY HOSPITAL   (France)

^d CEMAGREF   (France)

^e CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [7 (4 FLUOROPHENYL) 1,2,3,4 TETRAHYDRO 8 (4 PYRIDYL)PYRAZOLO[5,1 C][1,2,4]TRIAZIN 2 YL] 2 PHENYLETHANEDIONE; CD3 ANTIGEN; CREATININE; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BLOOD SAMPLING; CELL COUNT; CONTINUOUS INFUSION; CONTROLLED STUDY; CONVALESCENCE; CREATININE BLOOD LEVEL; CREATININE URINE LEVEL; CYTOKINE PRODUCTION; DISEASE MODEL; DRUG EFFECT; HEMINEPHRECTOMY; HISTOPATHOLOGY; INFLAMMATORY CELL; KIDNEY FAILURE; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY ISCHEMIA; KIDNEY PARENCHYMA; MALE; MORTALITY; NEPHRECTOMY; NEPHRITIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEINURIA; REPERFUSION INJURY; SHAM PROCEDURE; SURVIVAL RATE; SWINE; TREATMENT OUTCOME; URINALYSIS; URINE VOLUME;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CONSTRICTION; DISEASE MODELS, ANIMAL; FIBROSIS; INFLAMMATION; INFUSIONS, INTRAVENOUS; INTERLEUKIN-1; KIDNEY; KIDNEY FAILURE; KIDNEY FUNCTION TESTS; MALE; NECROSIS; NEPHRECTOMY; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEINURIA; PYRAZOLES; PYRIDINES; RECOVERY OF FUNCTION; REPERFUSION INJURY; SWINE; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; WARM ISCHEMIA;

EID: 61549123284     PISSN: 07415214     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jvs.2008.09.056     Document Type: Article

References (43)

1. Giulini S.M., Bonardelli S., Portolani N., Giovanetti M., Galvani G., Maffeis R., et al. Suprarenal aortic cross-clamping in elective abdominal aortic aneurysm surgery. Eur J Vasc Endovasc Surg 20 (2000) 286-289
2. Whalber E., Dimuzio P.J., and Stoney R.J. Aortic clamping during elective operations for infrarenal disease (the influence of clamping time on renal function). J Vasc Surg 36 (2002) 13-18
3. Sasaki T., Ohsawa S., Ogawa M., Mukaida M., Nakajima T., Komoda K., et al. Postoperative renal function after and abdominal aortic aneurysm repair requiring suprarenal aortic cross-clamp. Surg Today 30 (2000) 33-36
4. Myers S.I., Wang L., Liu F., and Bartula L.L. Suprarenal aortic clamping and reperfusion decreases medullary and cortical blood flow by decreased endogenous renal nitric oxide and PGE2 synthesis. J Vasc Surg 42 (2005) 524-531
5. Basile D.P., Danohoe D., Roethe K., and Osborn J.L. Renal ischemic injury results in permanent damage to peritubular capillaries and influences long term function. Am J Physiol Renal Physiol 281 (2001) F887-F899
6. Bonventre J.V., and Weinberg J.M. Recent advances in the pathophysiology of ischemic acute renal failure. J Am Soc Nephrol 14 (2003) 2199-2219
7. Nangaku M. Chronic hypoxia and tubulointerstitial injury: A final common pathway to end-stage renal failure. J Am Soc Nephrol 17 (2006) 17-25
8. Basile D.P. Rarefaction of peritubular capillaries following ischemic acute renal failure: A potential factor predisposing to progressive nephropathy. Curr Opin Nephrol Hypertens 13 (2004) 1-7
9. Bonomini V., Stefoni S., and Vagelisat A. Long-term patient and renal prognosis in acute renal failure. Nephron 36 (1984) 169-172
10. Briggs J., Kennedy A., Young L., Luke R., and Gray M. Renal function after acute tubular necrosis. Br Med J 3 (1967) 513-516
11. Lewers D., Mathew T.H., Maher J.F., and Schreiner G. Long-term follow-up of renal function and histology after acute tubular necrosis. Ann Int Med 73 (1970) 523-529
12. Devarajan P. Cellular and molecular derangements in acute tubular necrosis. Curr Opin Pediatr 17 (2005) 193-199
13. Dong X., Swaminathan S., Bachman L.A., Croatt A.J., Nath K.A., and Griffin M.D. Resident dendritic cells are the predominant TNF-secreting cell in early renal ischemia-reperfusion injury. Kidney Int 71 (2007) 619-628
14. Furuichi K., Wada T., Kaneko S., and Murphy P.M. Role of chemokines in renal ischemia/reperfusion injury. Front Biosci 13 (2008) 4021-4028
15. Wang Z., Canagarajah B.J., Boehm J.C., Kassisa S., Cobb M.H., Young P.R., et al. Structural basis of inhibitor selectivity in MAP kinases. Structure 6 (1998) 1117-1128
16. Wilson K.P., Fitzgibbon M.J., Caron P.R., Griffith J.P., Chen W., McCaffrey P.G., et al. Crystal structure of p38 mitogen-activated protein kinase. J Biol Chem 271 (1996) 27696-27700
17. Takahashi S., Keto Y., Fujita T., Uchiyama T., and Yamamoto A. FR167653, a p38 mitogen-activated kinase inhibitor, prevents helicobacter pylori-induced gastritis in mongolian gerbils. J Pharmacol Exp Ther 296 (2001) 48-56
18. Takeyoshi I., Iwanami K., Ohwada S., Kawashima Y., Kawata K., Aiba M., et al. Effect of FR167653 on small bowel ischemia-reperfusion injury in dogs. Dig Dis Sci 44 (1999) 2334-2343
19. Takiguchi M., Totsuka E., Umehara M., Ono H., Nara M., Nozaki T., et al. Attenuation of microirulatory disturbance after live ischemia by newly synthesized inflammatory cytokine suppressor, FR167653. Hepatogastroenterology 50 (2003) 789-793
20. Furuichi K., Wada T., Iwata Y., Sakai N., Yoshimoto K., Kobayasha K., et al. Administration of FR167653, a new anti-inflammatory compound, prevents renal ischemia/reperfusion injury in mice. Nephrol Dial Transplant 17 (2000) 399-407
21. Kitada H., Sugitani A., Yamamoto H., Otomo N., Okabe Y., Inoue S., et al. Attenuation of renal ischemia-reperfusion injury by FR167653 in dogs. Surgery 131 (2002) 654-662
22. Hashimoto N., Takeyoshi I., Yoshinari D., Tsutsumi H., Tokumine M., Totsuka O., et al. Effects of a p38 mitogen activated protein kinase inhibitor as an additive to Euro-Collins solution on reperfusion injury in canine lung transplantation. Transplantation 74 (2002) 320-326
23. Hauet T., Goujon J.M., Baumert H., Petit I., Carretier M., Eugene M., et al. Polyethylene glycol reduces the inflammatory injury due to cold ischemia/reperfusion in autotransplanted pig kidneys. Kidney Int 62 (2002) 654-667
24. Jayle C., Favreau F., Zhang K., Doucet C., Goujon J.M., Hebrard W., et al. Comparison of protective effects of trimetazidine against experimental warm ischemia of different durations: early and long-term effects in a pig kidney model. Am J Physiol Renal Physiol 292 (2007) F1082-F1093
25. Cau J., Favreau F., Tillement J.P., Lerman L.O., Hauet T., and Goujon J.M. Trimetazidine reduces early and long-term effects of experimental renal warm ischemia: a dose effect study. J Vasc Surg 47 (2008) 852-860
26. Zhang K., Desurmont T., Goujon J.M., Favreau F., Cau J., Deretz S., et al. Modulation of peripheral-type benzodiazepine receptor during ischemia reperfusion injury in a pig kidney model: a new partner of leukemia inhibitory factor in tubular regeneration. J Am Coll Surg 203 (2006) 353-364
27. Goujon J.M., Hauet T., Menet E., Levillain P., Babin P., and Carretier M. Histological evaluation of proximal tubule cell injury in isolated perfused pig kidneys exposed to cold ischemia. J Surg Res 82 (1999) 228-233
28. Grimm P.C., Nickerson P., Gough J., McKenna R., Stern E., Jeffery J., et al. Computerized image analysis of Sirius Red-staining renal allograft biopsies as a surrogate marker to predict long-term allograft function. J Am Soc Nephrol 14 (2003) 1662-1668
29. Louapre P., Grongnet J.F., Tanguay R.M., and David J.C. Effect of hypoxia on stress proteins in the piglet heart at birth. Cell Stress Chaperones 10 (2005) 17-23
30. Spurgeon-Pechman K.R., Donohoe D.L., Mattson D.L., Lund H., James L., and Basile D.P. Recovery from acute renal failure predisposes hypertension and secondary renal disease in response to elevated sodium. Am J Physiol Renal Physiol 293 (2007) F269-F278
31. Saikumar P., and Venkatachalam M.A. Role of apoptosis in hypoxic/ischemic damage in the kidney. Semin Nephrol 23 (2003) 511-521
32. Ortiz A., Justo P., Sanz A., Loez C., and Egido J. Targeting apoptosis in acute tubular injury. Biochem Pharmacol 66 (2003) 1589-1594
33. Rosenberger C., Rosen S., Shina A., Bernhardt W., Wiesner M.S., Frei U., et al. Hypoxia-inducible factors and tubular cell survival in isolated perfused kidneys. Kidney Int 70 (2006) 60-70
34. Cruzado J.M., Torras J., Riera M., Herreo I., Hueso M., Espinosa L., et al. Influence of nephron mass in development of chronic renal failure after prolonged warm renal ischemia. Am J Physiol Renal Physiol 279 (2000) F259-F269
35. Humphreys B., Valerius M.T., Kobayashi A., Mugford J.W., Soeung S., Duffield J.S., et al. Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell 6 (2008) 284-291
36. Zoja C., Donadelli R., Calleoni S., Figliuzzi M., Bonazzola S., Morigi M., et al. Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kB activation. Kidney Int 53 (1998) 1608-1615
37. Basile D.P., Donohoe D.L., Roethe K., and Mattson D.L. Chronic renal hypoxia after acute ischemic injury: effects of L-arginine on hypoxia and secondary damage. Am J Physiol Renal Physiol 284 (2003) F338-F348
38. Boros P., and Bromberg J.S. New cellular and molecular immune pathways in ischemia/reperfusion injury. Am J Transplant 6 (2006) 652-658
39. Burne-Taney M.J., Yokota N., and Rabb H. Persistent renal and extrarenal immune changes after severe ischemic injury. Kidney Int 67 (2005) 1002-1009
40. Bonventre J.V. Pathophysiology of acute kidney injury: roles of potential inhibitors of inflammation. Contrib Nephrol 156 (2007) 39-46
41. Takahashi S., Keto Y., Fujita T., Uchiyama T., and Yamamoto A. FR167653, a p38 mitogen-activated kinase inhibitor, prevents helicobacter pylori-induced gastritis in mongolian gerbils. J Pharmacol Exp Ther 296 (2001) 48-56
42. Wang X., and Liu Y. Regulation of innate immune response by MAP kinase phosphatase-1. Cell Signal 19 (2007) 1372-1382
43. Donnahoo K.K., Meldrum D.R., Shenkar R., Chung C.S., Abraham E., and Harken A.H. Early renal ischemia, with or without reperfusion, activates NFkappaB and increases TNF-alpha bioactivity in the kidney. J Urol 163 (2000) 1328-1332