PGE2 signal via EP2 receptors evoked by a selective agonist enhances regeneration of injured articular cartilage

Osteoarthritis and Cartilage

Volumn 17, Issue 4, 2009, Pages 529-538

  Otsuka, S ^a,b   Aoyama, T ^a   Furu, M ^a,c   Ito, K ^a,b   Jin, Y ^a   Nasu, A ^a,c   Fukiage, K ^a,c   Kohno, Y ^a,c   Maruyama, T ^d   Kanaji, T ^d   Nishiura, A ^d   Sugihara, H ^d   Fujimura, S ^d   Otsuka, T ^b   Nakamura, T ^c   Toguchida, J ^a  

^a KYOTO UNIVERSITY   (Japan)

^b NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d ONO PHARMACEUTICAL CO   (Japan)

Author keywords

Agonist; Cartilage; Defect; EP2; Osteoarthritis; PGE2; Repair; Therapeutic drug

Indexed keywords

C REACTIVE PROTEIN; COLLAGEN TYPE 2; CYCLINE; INTERLEUKIN 1BETA; MESSENGER RNA; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E RECEPTOR 2; PROSTAGLANDIN E RECEPTOR 2 STIMULATING AGENT; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR; PROSTAGLANDIN RECEPTOR STIMULATING AGENT; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE INJURY; CHONDROPATHY; CONTROLLED STUDY; ENZYME ACTIVITY; FEMUR; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; KNEE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYNOVIAL FLUID; SYNOVITIS; TISSUE REGENERATION; TISSUE REPAIR; AGONISTS; ANIMAL; ARTICULAR CARTILAGE; CELL PROLIFERATION; DISEASE MODEL; DRUG EFFECTS; DRUG SCREENING; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROCEDURES; RABBIT; REGENERATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNOVIUM;

ANIMALS; C-REACTIVE PROTEIN; CARTILAGE, ARTICULAR; CELL PROLIFERATION; DINOPROSTONE; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; MATRIX METALLOPROTEINASE 3; RABBITS; RECEPTORS, PROSTAGLANDIN E; REGENERATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SYNOVIAL FLUID; SYNOVIAL MEMBRANE; TUMOR NECROSIS FACTOR-ALPHA; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE;

EID: 61549117532     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2008.09.003     Document Type: Article

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