Effect of concomitant administration of meropenem and valproic acid in an elderly chinese patient

American Journal Geriatric Pharmacotherapy

Volumn 7, Issue 1, 2009, Pages 26-33

  Gu, Jie ^a   Huang, Yanyan ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

concomitant; meropenem; seizures; valproic acid

Indexed keywords

CARBAPENEM DERIVATIVE; CEFMETAZOLE; DIAZEPAM; MEROPENEM; PHENOBARBITAL; SULPERAZON; TOPIRAMATE; VALPROIC ACID;

AGED; ARTICLE; BACTERIAL PNEUMONIA; CASE REPORT; CHINESE; DRUG ANTAGONISM; DRUG BLOOD LEVEL; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG SUBSTITUTION; DRUG WITHDRAWAL; EPILEPSY; EVENING DOSAGE; FOCAL EPILEPSY; GERIATRIC PATIENT; HOSPITAL INFECTION; HUMAN; KLEBSIELLA PNEUMONIAE; MALE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SPUTUM CULTURE; TONIC CLONIC SEIZURE;

AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; ANTICONVULSANTS; DRUG ADMINISTRATION SCHEDULE; DRUG INTERACTIONS; DRUG MONITORING; HUMANS; MALE; PNEUMONIA; SEIZURES; THIENAMYCINS; TREATMENT OUTCOME; VALPROIC ACID;

EID: 61549103148     PISSN: 15435946     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjopharm.2009.02.005     Document Type: Article

References (33)

1. Norrby S.R., and Gildon K.M. Safety profile of meropenem: A review of nearly 5,000 patients treated with meropenem. Scand J Infect Dis 31 (1999) 3-10
2. Rimmer E.M., and Richens A. An update on sodium valproate. Pharmacotherapy 5 (1985) 171-184
3. Nagai K., Shimizu T., Togo A., et al. Decrease in serum levels of valproic acid during treatment with a new carbapenem, panipenem/betamipron. J Antimicrob Chemother 39 (1997) 295-296
4. De Turck B.J., Diltoer M.W., Cornelis P.J., et al. Lowering of plasma valproic acid concentrations during concomitant therapy with meropenem and amikacin. J Antimicrob Chemother 42 (1998) 563-564
5. Llinares Tello F., Bosacoma Ros N., Hernández Prats C., et al. Pharmacokinetic interaction between valproic acid and carbapenem-like antibiotics: A discussion of three cases [in Spanish]. Farm Hosp 27 (2003) 258-263
6. Santucci M., Parmeggiani A., and Riva R. Seizure worsening caused by decreased serum valproate during meropenem therapy. J Child Neurol 20 (2005) 456-457
7. Nacarkucuk E., Saglam H., and Okan M. Meropenem decreases serum level of valproic acid. Pediatr Neurol 31 (2004) 232-234
8. Coves-Orts F.J., Borrás-Blasco J., Navarro-Ruiz A., et al. Acute seizures due to a probable interaction between valproic acid and meropenem. Ann Pharmacother 39 (2005) 533-537
9. Lam F. Valproic acid taken with meropenem may result in seizures. Brown Univ Psychopharmacol Update 16 (2005) 2-3
10. Clause D., Decleire P.Y., Vanbinst R., et al. Pharmacokinetic interaction between valproic acid and meropenem. Intensive Care Med 31 (2005) 1293-1294
11. Fudio S., Carcas A., Piñana E., and Ortega R. Epileptic seizures caused by low valproic acid levels from an interaction with meropenem. J Clin Pharm Ther 31 (2006) 393-396
12. Lee S.G., Kim J.H., Joo J.Y., and Kwon O.H. Seven cases of decreased serum valproic acid concentration during concomitant use of carbapenem antibiotics [in Korean]. Korean J Lab Med 27 (2007) 338-343
13. Sprier I., Meersseman W., Troy E.D., et al. Meropenemvalproic acid interaction in patients with cefepimeassociated status epilepticus. Am J Health-Syst Pharm 64 (2007) 54-58
14. Martinez I.S., Gonzalez C.F., Gonzalez A.H., et al. Interaction between valproic acid and meropenem: Description of two pediatric cases. Atencion Farmaceutica 10 (2008) 121-124
15. Moczygemba L.R., Frei C.R., and Burgess D.S. Pharmacodynamic modeling of carbapenems and fluoroquinolones against bacteria that produce extended-spectrum betalactamases. Clin Ther 26 (2004) 1800-1807
16. Naranjo C.A., Busto U., Sellers E.M., et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 30 (1981) 239-245
17. Cunha B.A. Meropenem in elderly and renally inpaired patients [corrected and republished in Int J Antimicrob Agents. 1999;11:167-177]. Int J Antimicrob Agents 10 (1998) 107-117
18. Calandra G., Lydick E., Carrigan J., et al. Factors predisposing to seizures in seriously ill infected patients receiving antibiotics: Experience with imipenem/cilastatin. Am J Med 84 (1988) 911-918
19. Mauna H.J. Drug-associated disease: Cytochrome P450 interactions. Crit Care Clin 22 (2006) 329-345
20. Pisani F. Influence of co-medication on the metabolism of valproate. Pharm Weekbl Sci 14 (1992) 108-113
21. Zaccara G., Messori A., and Moroni F. Clinical pharmacokinetics of valproic acid-1988. Clin Pharmacokinet 15 (1988) 367-389
22. Bax R.P., Bastain W., Featherstone A., et al. The pharmacokinetics of meropenem in volunteers. J Antimicrob Chemother 24 Suppl A (1989) 311-320
23. Urien S., Albengres E., and Tillement J.P. Serum protein binding of valproic acid in healthy subjects and in patients with liver disease. Int J Clin Pharmacol Ther Toxicol 19 (1981) 319-325
24. Keller F., Maiga M., Neumayer H.H., et al. Pharmacokinetic effects of altered plasma protein binding of drugs in renal disease. Eur J Drug Metab Pharmacokinet 9 (1984) 275-282
25. Yokogawa K., Iwashita S., Kubota A., et al. Effect of meropenem on disposition kinetics of valproate and its metabolites in rabbits. Pharm Res 18 (2001) 1320-1326
26. Torii M., Takiguchi Y., Saito F., et al. Inhibition by carbapenem antibiotic imipenem of intestinal absorption of valproic acid in rats. J Pharm Pharmacol 53 (2001) 823-829
27. Nakajima Y., Mizobuchi M., Nakamura M., et al. Mechanism of the drug interaction between valproic acid and carbapenem antibiotics in monkeys and rats. Drug Metab Dispos 32 (2004) 1383-1391
28. Ogawa K., Yumoto R., Hamada N., et al. Interaction of valproic acid and carbapenem antibiotics with multidrug resistance-associated proteins in rat erythrocyte membranes. Epilepsy Res 71 (2006) 76-87
29. Wong V.K., Wright Jr. H.T., Ross L.A., et al. Imipenem/cilastatin treatment of bacterial meningitis in children. Pediatr Infect Dis J 10 (1991) 122-125
30. Abou Khaled K.J., and Hirsch L.J. Advances in the management of seizures and status epilepticus in critically ill patients. Crit Care Clin 22 (2006) 637-659
31. De Sarro A., Ammendola D., Zappala M., et al. Relationship between structure and convulsant properties of some beta-lactam antibiotics following intracerebroventricular microinjection in rats. Antimicrob Agents Chemother 39 (1995) 232-237
32. Sieger B., Berman S.J., Geckler R.W., and Farkes S.A. Empiric treatment of hospital-acquired lower respiratory tract infections with meropenem or ceftazidime with tobramycin: A randomized study. Meropenem Lower Respiratory Infection Group [published correction appears in Crit Care Med. 1997;25:2067]. Crit Care Med 25 (1997) 1663-1670
33. Calandra G., Lydick E., Carrigan J., et al. Factors predisposing to seizures in seriously ill infected patients receiving antibiotics: Experience with imipenem/cilastatin. Am J Med 84 (1988) 911-918