Clarifying allosteric control of flap conformations in the 1TW7 crystal structure of HIV-1 protease

Proteins: Structure, Function and Bioinformatics

Volumn 74, Issue 4, 2009, Pages 872-880

  Lexa, Katrina W ^a   Damm, Kelly L ^a   Quintero, Jerome J ^a   Gestwicki, Jason E ^a   Carlson, Heather A ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

AIDS; Drug design; Ligand binding; Molecular dynamics; Protein flexibility

Indexed keywords

PROTEINASE; P16 PROTEASE, HUMAN IMMUNODEFICIENCY VIRUS 1; PEPTIDE;

ALLOSTERISM; ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; PRIORITY JOURNAL; PROTEIN CONFORMATION; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; PROTEIN FOLDING; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ALLOSTERIC SITE; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; HIV PROTEASE; MODELS, MOLECULAR; PEPTIDES; PROTEIN CONFORMATION; PROTEIN FOLDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 61449265073     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.22195     Document Type: Article

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