Gender issues in acute stroke thrombolysis

Journal of Clinical Neuroscience

Volumn 16, Issue 4, 2009, Pages 501-504

  De Silva, D A ^a   Ebinger, M ^a   Davis, S M ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Acute; Female; Gender; Male; Sex; Stroke; Thrombolysis

Indexed keywords

FIBRINOLYTIC AGENT;

BLOOD CLOT LYSIS; CLINICAL ASSESSMENT; CLINICAL DECISION MAKING; HOSPITAL ADMISSION; HUMAN; POST HOC ANALYSIS; PRIORITY JOURNAL; RECANALIZATION; REVIEW; SEX DIFFERENCE; STROKE; THROMBOSIS; TREATMENT OUTCOME;

FIBRINOLYTIC AGENTS; HUMANS; PATIENT SELECTION; SEX CHARACTERISTICS; STROKE; THROMBOLYTIC THERAPY;

EID: 61449255923     PISSN: 09675868     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jocn.2008.07.068     Document Type: Review

References (48)

1. Pilote L., Dasgupta K., Guru V., et al. A comprehensive view of sex-specific issues related to cardiovascular disease. CMAJ 176 (2007) S1-S44
2. Kinsella K, Gist YJ. Gender and Aging. Mortality and Health. International Brief. US Department of Commerce, Economics and Statistics Administration. Bureau of the Census. Washington DC, US. October 7. 1998.
3. Giampaoli S. Epidemiology of major age-related diseases in women compared to men. Aging (Milano) 12 (2000) 93-105
4. Guralnik J.M., Balfour J.L., and Volpato S. The ratio of older women to men: historical perspectives and cross-national comparisons. Aging (Milano) 12 (2000) 65-76
5. Chen C.I., Iguchi Y., Grotta J.C., et al. Intravenous tPA for very old stroke patients. Eur Neurol 54 (2005) 140-144
6. Wyller T.B. Stroke and gender. J Gend Specif Med 2 (1999) 41-45
7. Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med 1995;333:1581-7.
8. Lisabeth L.D., Brown D.L., and Morgenstern L.B. Barriers to intravenous tissue plasminogen activator for acute stroke therapy in women. Gend Med 3 (2006) 270-278
9. Foerch C., Misselwitz B., Humpich M., et al. Sex disparity in the access of elderly patients to acute stroke care. Stroke 38 (2007) 2123-2126
10. Yamaguchi K., Hori S., Nogawa S., et al. Thrombolysis candidates for the treatment of stroke at an emergency department in Japan. Acad Emerg Med 9 (2002) 754-758
11. Barr J., McKinley S., O'Brien E., et al. Patient recognition of and response to symptoms of TIA or stroke. Neuroepidemiology 26 (2006) 168-175
12. Derex L., Adeleine P., Nighoghossian N., et al. Factors influencing early admission in a French stroke unit. Stroke 33 (2002) 153-159
13. Kapral M.K., Fang J., Hill M.D., et al. Sex differences in stroke care and outcomes: results from the Registry of the Canadian Stroke Network. Stroke 36 (2005) 809-814
14. Reid J.M., Dai D., Gubitz G.J., et al. Gender differences in stroke examined in a 10-year cohort of patients admitted to a Canadian teaching hospital. Stroke 39 (2008) 1090-1095
15. Harraf F., Sharma A.K., Brown M.M., et al. A multicentre observational study of presentation and early assessment of acute stroke. BMJ 325 (2002) 17
16. Morris D.L., Rosamond W., Madden K., et al. Prehospital and emergency department delays after acute stroke: the Genentech Stroke Presentation Survey. Stroke 31 (2000) 2585-2590
17. Goldstein L.B., Edwards M.G., and Wood D.P. Delay between stroke onset and emergency department evaluation. Neuroepidemiology 20 (2001) 196-200
18. Harper G.D., Haigh R.A., Potter J.F., et al. Factors delaying hospital admission after stroke in Leicestershire. Stroke 23 (1992) 835-838
19. Azzimondi G., Bassein L., Fiorani L., et al. Variables associated with hospital arrival time after stroke: effect of delay on the clinical efficiency of early treatment. Stroke 28 (1997) 537-542
20. Chang K.C., Tseng M.C., and Tan T.Y. Prehospital delay after acute stroke in Kaohsiung, Taiwan. Stroke 35 (2004) 700-704
21. De Silva D.A., Ong S.H., Elumbra D., et al. Timing of hospital presentation after acute cerebral infarction and patients' acceptance of intravenous thrombolysis. Ann Acad Med Singapore 36 (2007) 244-246
22. Labiche L.A., Chan W., Saldin K.R., et al. Sex and acute stroke presentation. Ann Emerg Med 40 (2002) 453-460
23. Roquer J., Campello A.R., and Gomis M. Sex differences in first-ever acute stroke. Stroke 34 (2003) 1581-1585
24. Di Carlo A., Lamassa M., Baldereschi M., et al. Sex differences in the clinical presentation, resource use, and 3-month outcome of acute stroke in Europe: data from a multicenter multinational hospital-based registry. Stroke 34 (2003) 1114-1119
25. Engelter S.T., Gostynski M., Papa S., et al. Epidemiology of aphasia attributable to first ischemic stroke: incidence, severity, fluency, etiology, and thrombolysis. Stroke 37 (2006) 1379-1384
26. Barrett K.M., Brott T.G., Brown Jr. R.D., et al. Sex differences in stroke severity, symptoms, and deficits after first-ever ischemic stroke. J Stroke Cerebrovasc Dis 16 (2007) 34-39
27. Schumacher H.C., Bateman B.T., Boden-Albala B., et al. Use of thrombolysis in acute ischemic stroke: analysis of the Nationwide Inpatient Sample 1999 to 2004. Ann Emerg Med 50 (2007) 99-107
28. Reed S.D., Cramer S.C., Blough D.K., et al. Treatment with tissue plasminogen activator and inpatient mortality rates for patients with ischemic stroke treated in community hospitals. Stroke 32 (2001) 1832-1840
29. Deng Y.Z., Reeves M.J., Jacobs B.S., et al. IV tissue plasminogen activator use in acute stroke: experience from a statewide registry. Neurology 66 (2006) 306-312
30. Katzan I.L., Hammer M.D., Hixson E.D., et al. Utilization of intravenous tissue plasminogen activator for acute ischemic stroke. Arch Neurol 61 (2004) 346-350
31. Kapral M.K., Devon J., Winter A.L., et al. Gender differences in stroke care decision-making. Med Care 44 (2006) 70-80
32. Ciccone A., Sterzi R., Crespi V., et al. Thrombolysis for acute ischemic stroke: the patient's point of view. Cerebrovasc Dis 12 (2001) 335-340
33. Kent D.M., Price L.L., Ringleb P., et al. Sex-based differences in response to recombinant tissue plasminogen activator in acute ischemic stroke: a pooled analysis of randomized clinical trials. Stroke 36 (2005) 62-65
34. Niewada M., Kobayashi A., Sandercock P.A., et al. Influence of gender on baseline features and clinical outcomes among 17,370 patients with confirmed ischaemic stroke in the International Stroke Trial. Neuroepidemiology 24 (2005) 123-128
35. Savitz S.I., Schlaug G., Caplan L., et al. Arterial occlusive lesions recanalize more frequently in women than in men after intravenous tissue plasminogen activator administration for acute stroke. Stroke 36 (2005) 1447-1451
36. Elkind M.S., Prabhakaran S., Pittman J., et al. Sex as a predictor of outcomes in patients treated with thrombolysis for acute stroke. Neurology 68 (2007) 842-848
37. Saposnik G., Di Legge S., Webster F., et al. Predictors of major neurologic improvement after thrombolysis in acute stroke. Neurology 65 (2005) 1169-1174
38. Kent DM, Buchan AM, Hill MD. The gender effect in stroke thrombolysis. Of CASES, controls, and treatment-effect modification. Neurology 2008. [Epub ahead of print].
39. Horita K., Eto M., Saito M., et al. Effects of apolipoprotein E polymorphism on plasma lipoprotein(a) levels. Artery 20 (1993) 324-336
40. Hill M.D., Kent D.M., Hinchey J., et al. Sex-based differences in the effect of intra-arterial treatment of stroke: analysis of the PROACT-2 study. Stroke 37 (2006) 2322-2325
41. Sandercock P., and Lewis S. Sex-based differences in the effect of intra-arterial treatment of stroke: a plea to stop torturing the old data and do large trials!. Stroke 37 (2006) 2198
42. Kent D.M., and Hill M.D. Differences in response to reperfusion therapies in acute stroke between men and women: mediated by sex or by chance?. Stroke 37 (2006) 2878-2879
43. Arnold M., Kappeler L., Nedeltchev K., et al. Recanalization and outcome after intra-arterial thrombolysis in middle cerebral artery and internal carotid artery occlusion: does sex matter?. Stroke 38 (2007) 1281-1285
44. Shah S.H., Liebeskind D.S., Saver J.L., et al. Influence of gender on outcomes after intra-arterial thrombolysis for acute ischemic stroke. Neurology 66 (2006) 1745-1746
45. Ezaki Y., Tsutsumi K., Onizuka M., et al. Retrospective analysis of neurological outcome after intra-arterial thrombolysis in basilar artery occlusion. Surg Neurol 60 (2003) 423-430
46. Liebeskind D.S., Laughton A.L., Kim D., et al. Vessel size explains gender differences in response to intravenous thrombolysis for acute stroke. Stroke 37 (2006) 622
47. Buck B.H., Kim D., Saver J.L., et al. The volume of middle cerebral artery thrombi: Assessment by GRE MRI, gender differences, and relation to response to fibrinolytic therapy. Stroke 37 (2006) 648
48. Molina C.A., Montaner J., Arenillas J.F., et al. Differential pattern of tissue plasminogen activator-induced proximal middle cerebral artery recanalization among stroke subtypes. Stroke 35 (2004) 486-490