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Volumn 13, Issue 1, 2009, Pages 49-53

An improved process for the synthesis and isolation of (S)-N-(1- phenylettiyl)hydroxylamine

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EID: 61449246596     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op800230f     Document Type: Article
Times cited : (7)

References (21)
  • 11
    • 0036859486 scopus 로고    scopus 로고
    • For the description of a large-scale preparation of a nitrone via the oxidation of a secondary amine with m-CPBA, see: Stappers, F.; Broeckx, R.; Leurs, S.; Van Den Bergh, L.; Agten, J.; Lambrechts, A.; Van den Heuvel, D.; De Smaele, D. Org. Process. Res. Dev. 2002, 6, 911. It is interesting to note that this oxidation presumably goes via the intermediacy of a hydroxylamine.
    • For the description of a large-scale preparation of a nitrone via the oxidation of a secondary amine with m-CPBA, see: Stappers, F.; Broeckx, R.; Leurs, S.; Van Den Bergh, L.; Agten, J.; Lambrechts, A.; Van den Heuvel, D.; De Smaele, D. Org. Process. Res. Dev. 2002, 6, 911. It is interesting to note that this oxidation presumably goes via the intermediacy of a hydroxylamine.
  • 16
    • 61449172302 scopus 로고    scopus 로고
    • Urben, P. G, Ed, 6th ed; Butterworth-Heinemann: Oxford, UK
    • Urben, P. G., Ed.; Bretherick's Handbook of Reactive Chemical Hazards, 6th ed; Butterworth-Heinemann: Oxford, UK, 1999; Vol. 1, pp 1662-1664.
    • (1999) Bretherick's Handbook of Reactive Chemical Hazards , vol.1 , pp. 1662-1664
  • 17
    • 61449178186 scopus 로고    scopus 로고
    • For an example of a process using m-CPBA in EtOAc for the oxidation of a sulfide to a sulfoxide, see: Milač, N. H, Jereb D, U.S. Patent 6,268,502, 2001
    • For an example of a process using m-CPBA in EtOAc for the oxidation of a sulfide to a sulfoxide, see: Milač, N. H.; Jereb D, U.S. Patent 6,268,502, 2001.
  • 18
    • 0347996091 scopus 로고    scopus 로고
    • For use of m-CPBA as a solution in EtOH and associated discussion, see: Prasad, J. S.; Vu, T.; Totleben, M. J.; Crispino, G. A.; Kacsur, D. J.; Swaminathan, S.; Thornton, J. E.; Fritz, A.; Singh, A. K. Org. Process Res. Dev. 2003, 7, 821.
    • For use of m-CPBA as a solution in EtOH and associated discussion, see: Prasad, J. S.; Vu, T.; Totleben, M. J.; Crispino, G. A.; Kacsur, D. J.; Swaminathan, S.; Thornton, J. E.; Fritz, A.; Singh, A. K. Org. Process Res. Dev. 2003, 7, 821.
  • 20
    • 61449160461 scopus 로고    scopus 로고
    • Proton and carbon NMR analysis after 5 years storage at room temperature showed no discernable degradation.
    • Proton and carbon NMR analysis after 5 years storage at room temperature showed no discernable degradation.
  • 21
    • 61449245825 scopus 로고    scopus 로고
    • Patel, I.; Smith, N.; Tyler, S. N. G. PCT Int. Appl. WO 2008/029090, 2008.
    • Patel, I.; Smith, N.; Tyler, S. N. G. PCT Int. Appl. WO 2008/029090, 2008.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.