Response to dancer's comments on our article "substrate modification approach to achieve efficient resolution: Didesmethylcitalopram: A key intermediate for escitalopram" [Org. Process Res. Dev. 2007, 11, 289-292]

Organic Process Research and Development

Volumn 13, Issue 1, 2009, Pages 34-37

  Elati, Chandrashekar R ^a   Kolla, Naveenkumar ^a   Mathad, Vijayavitthal T ^a  

^a DR REDDY'S LABORATORIES LTD   (India)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 61449244689     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op8002079     Document Type: Article

References (6)

1. Elati, C. R.; Kolla, N.; Vankawala, P. J.; Gangula, S.; Chalamala, S.; Sundaram, V.; Bhattacharya, A.; Vurimidi, H.; Mathad, V. T. Org. Process Res. Dev. 2007, 11, 289-292.
2. Dancer, R. J.; Lopez de Diego, H. Org. Process Res. Dev. 2008, 13, 23-33.
3. Sundaram, V.; Mathad, V. T.; Elati, R. R. C.; Kolla, N.; Vankawala, P. J.; Govindan, S.; Chalamala, S.; Gangula, S. WO Patent 047274; Chem. Abstr. 2005, 142, 481937.
4. Enantiopurity was estimated by chiral HPLC analysis with Chiralcel ODH, 250 mm × 4.6 mm, 5 μ; mobile phase: 2-propanol, n-hexane, and diethylamine in the ratio of 50:950:2.0 (v/v); 0.8 mL/min; 240 nm.
5. Kharasch, M. S.; Fuchs, C. F. J. Org. Chem. 1945, 10, 159-169.
6. Purity of 3 was estimated by HPLC analysis with Inertsil ODS 3V, 250 mm × 4.6 mm, 5 μ; mobile phase A: mixture of buffer and acetonitrile in the ratio of 800:200; mobile phase B: mixture of acetonitrile and buffer in the ratio of 700:300; run time: 60 min, 240 nm. Buffer preparation: to 1000 mL of water was added 0.5 mL of phosphoric acid, and the pH was adjusted to 3.5 with triethylamine.