Substrate modification approach to achieve efficient resolution: Didesmethylcitalopram: A key intermediate for escitalopram

Organic Process Research and Development

Volumn 11, Issue 2, 2007, Pages 289-292

  Elati, Chandrashekar R ^a   Kolla, Naveenkumar ^a   Vankawala, Pravinchandra J ^a   Gangula, Srinivas ^a   Chalamala, Subrahmanyeswarara ^a   Sundaram, Venkatraman ^a   Bhattacharya, Apurba ^a   Vurimidi, Himabindu ^b   Mathad, Vijayavitthal T ^a  

^a DR REDDY'S LABORATORIES LTD   (India)

^b JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 34247251966     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op060175e     Document Type: Article

References (19)

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12. 3a
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15. For this experimental study (+)-4 of 85% chiral purity is employed.
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18. Enantiopurity of (+)-4 was estimated by chiral HPLC analysis with Chiralcel ADH, 5.0 μm, 250 × 4.6 mm; mobile phase: n-hexane, ethanol, diethylamine, and propionic acid in the ratio of 85:15:0.2:2.0 (v/v); 0.8 mL/min; 240 nm.
19. Enantiopurity of 1 was estimated by chiral HPLC analysis with Chiralcel ODH, 250 × 4.6 mm, 5 μm; mobile phase: 2-propanol, n-hexane, and diethylamine in the ratio of 50:950:2.0 (v/v); 0.8 mL/min; 240 nm.