High dose erythropoietin promotes functional recovery of rats following facial nerve crush

Journal of Clinical Neuroscience

Volumn 16, Issue 4, 2009, Pages 554-556

  Zhang, Wei ^a   Sun, Bin ^a   Yu, Ziying ^a   An, Jiping ^a   Liu, Qilin ^a   Ren, Taotao ^a  

^a JILIN UNIVERSITY   (China)

Author keywords

Epo; Erythropoietin; Facial nerve crush; Functional recovery

Indexed keywords

ERYTHROPOIETIN; PLACEBO;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CONVALESCENCE; DRUG EFFECT; DRUG MEGADOSE; EYELID REFLEX; FACIAL NERVE INJURY; NERVE CRUSH; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; WHISKER MOVEMENT;

ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; BLINKING; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ERYTHROPOIETIN; FACIAL NERVE INJURIES; HUMANS; NEUROPROTECTIVE AGENTS; RATS; RATS, WISTAR; RECOVERY OF FUNCTION; TIME FACTORS; VIBRISSAE;

EID: 61449197613     PISSN: 09675868     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jocn.2008.06.013     Document Type: Article

References (30)

1. Sendtner M., Kreutzberg G.W., and Thoenen H. Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy. Nature 345 (1990) 440-441
2. Hughes R.A., Sendtner M., and Thoenen H. Members of several gene families influence survival of rat motoneurons in vitro and in vivo. J Neurosci Res 36 (1993) 663-671
3. Spector J.G., Lee P., Derby A., et al. Rabbit facial nerve regeneration in NGF-containing silastic tubes. Laryngoscope 103 (1993) 548-558
4. Sendtner M., Dittrich F., Hughes R.A., et al. Actions of CNTF and neurotrophins on degenerating motoneurons: preclinical studies and clinical implications. J Neurol Sci 124 Suppl (1994) 77-83
5. Li L., Oppenheim R.W., Lei M., et al. Neurotrophic agents prevent motoneuron death following sciatic nerve section in the neonatal mouse. J Neurobiol 25 (1994) 759-766
6. Kohmura E., Yuguchi T., Yoshimine T., et al. BDNF atelocollagen mini-pellet accelerates facial nerve regeneration. Brain Res 849 (1999) 235-238
7. Mohiuddin L., Delcroix J.D., Fernyhough P., et al. Focally administered nerve growth factor suppresses molecular regenerative responses of axotomized peripheral afferents in rats. Neuroscience 91 (1999) 265-271
8. Genc S., Koroglu T.F., and Genc K. Erythropoietin and the nervous system. Brain Res 1000 (2004) 19-31
9. King C.E., Rodger J., Bartlett C., et al. Erythropoietin is both neuroprotective and neuroregenerative following optic nerve transaction. Exp Neurol 205 (2007) 48-55
10. Keswani S.C., Buldanlioglu U., Fischer A., et al. A novel endogenous erythropoietin mediated pathway prevents axonal degeneration. Ann Neurol 51 (2004) 815-826
11. Allaf M.E., Hoke A., and Burnett A.L. Erythropoietin promotes the recovery of erectile function following cavernous nerve injury. J Urol 174 (2005) 2060-2064
12. Celik M., Gokmen N., Erbayraktar S., et al. Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury. Proc Natl Acad Sci USA 99 (2002) 2258-2263
13. Terao E., Janssens S., van den Bosch de Aguilar S., et al. In vivo expression of the intermediate filament peripherin in rat motoneurons: modulation by inhibitory and stimulatory signals. Neuroscience 101 (2000) 679-688
14. Lykissas M.G., Sakellarious E., Vekris M.D., et al. Axonal regeneration stimulated by erythropoietin: An experimental study in rats. J Neurosci Methods 164 (2007) 107-115
15. Serpe C.J., Tetzlaff J.E., Coers S., et al. Functional recovery after facial nerve crush is delayed in severe combined immunodeficient mice. Brain Behavior Immunity 16 (2002) 808-812
16. Soreide A.J. Variations in the axon reaction in animals of different ages. A light microscopic study on the facial nucleus of the rat. Acta Anat (Basel) 110 (1981) 40-47
17. Casanovas A., Ribera J., Hukkanen M., et al. Prevention by lamotrigine, MK-801 and N omega-nitro-L-arginine methyl ester of motoneuron cell death after neonatal axotomy. Neuroscience 71 (1996) 313-325
18. Hall E.D., Smith S.L., and Oostveen J.A. Inhibition of lipid peroxidation attenuates axotomy-induced apoptotic degeneration of facial motor neurons in neonatal rats. J Neurosci Res 44 (1996) 293-299
19. Nadam J., Navarro F., Sanchez P., et al. Neuroprotective effects of erythropoietin in the rat hippocampus after pilocarpine-induced status epilepticus. Neurobiol Dis 25 (2007) 412-426
20. Keller M., Yang J.L., Griesmaier E., et al. Erythropoietin is neuroprotective against NMDA-receptor-mediated excitotoxic brain injury in newborn mice. Neurobiol Dis 24 (2006) 357-366
21. Grunfeld J.F., Barhum Y., Blondheim N., et al. Erythropoietin delays disease onset in an amyotrophic lateral sclerosis model. Exp Neurology 204 (2007) 260-263
22. McClure M.M., Threlkeld S.W., and Fitch R.H. Auditory processing and learning/memory following erythropoietin administration in neonatally hypoxic-ischemic injured rats. Brain Res 1132 (2007) 203-209
23. Juul S. Erythropoietin in the central nervous system and its use to prevent hypoxic-ischemic brain damage. Acta Paediatr Suppl 91 (2002) 36-42
24. Keswani S.C., Buldanlioglu U., Fischer A., et al. A novel endogenous erythropoietin mediated pathway prevents axonal degeneration. Ann Neurol 56 (2004) 815-826
25. Tsai P.T., Ohab J.J., Kertesz N., et al. A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J Neuroscience 26 (2006) 1269-1274
26. Campana W.M., and Myers R.R. Erythropoietin and erythropoietin receptors in the peripheral nervous system: changes after nerve injury. FASEB J 15 (2001) 1804-1806
27. Brines M.L., Ghezzi P., Keenan S., et al. Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc Natl Acad Sci USA 97 (2000) 10526-10531
28. Ehrenreich H., Degner D., Meller J., et al. Erythropoietin: a candidate compound for neuroprotection in schizophrenia. Mol Psychiatry 9 (2004) 42-54
29. Brines M., and Ceremi A. Emerging biological roles for erythropoietin in the nervous system. Nat Rev Neurosci 6 (2005) 484-494
30. Chen Y.S., Murakami S., Gyo K., et al. Effects of basic fibroblast growth factor (bFGF)-neutralizing antibody and platelet factor 4 on facial nerve regeneration. Exp Neurol 155 (1999) 274-283