From cho-cell to stem-cell biotechnology, oxygenation, and mixing in animal-aell culture: bioreactors, bubbles, and bell injury

Biotechnology and Bioengineering

Volumn 102, Issue 4, 2009, Pages 977-979

  Papoutsakis, E T ^a  

^a University of Delaware   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; BIOREACTOR; BIOTECHNOLOGY; CELL DAMAGE; CHO CELL; SHORT SURVEY; STEM CELL;

ANIMALIA;

EID: 61449195210     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22263     Document Type: Short Survey

References (22)

1. Abranches E, Bekman E, Henrique D, Cabral JMS. 2007. Expansion of mouse embryonic stem cells on microcarriers. Biotechnol Bioeng 96:1211-1221.
2. Bavarian F, Fan LS, Chalmers JJ. 1991. Microscopic visualization of insect cell bubble interactions. 1. Rising bubbles, air medium interface, and the foam layer. Biotechnol Progr 7:140-150.
3. Boultonstone JM, Blake JR. 1993. Gas-bubbles bursting at a free-surface. J Fluid Mech 254:437-466.
4. Chalmers JJ, Bavarian F. 1991. Microscopic visualization of insect cell bubble interactions 2. The bubble film and bubble rupture. Biotechnol Progr 7:151-158.
5. Cherry RS, Papoutsakis ET. 1986. Hydrodynamic effects on cells in agitated tissue-culture reactors. Bioprocess Eng 1:29-41.
6. Cherry RS, Papoutsakis ET. 1988. Physical-mechanisms of cell-damage in microcarrier cell-culture bioreactors. Biotechnol Bioeng 32:1001 -1014.
7. Collins PC, Miller WM, Papoutsakis ET. 1998. Stirred culture of peripheral and cord blood hematopoietic cells offers advantages over traditional static systems for clinically relevant applications. Biotechnol Bioeng 59:534-543.
8. Croughan MS, Hamel JF, Wang DIC. 1987. Hydrodynamic effects on animal-cells grown in microcarrier cultures. Biotechnol Bioeng 29:130-141.
9. Croughan MS, Sayre ES, Wang DIC. 1989. Viscous reduction of turbulent damage in animal-cell culture. Biotechnol Bioeng 33:862-872.
10. Kirouac DC, Zandstra PW. 2008. The systematic production of cells for cell therapies. Cell Stem Cell 3:369-381.
11. Kunas KT, Papoutsakis ET. 1990. Damage mechanisms of suspended animal-cells in agitated bioreactors with and without bubble entrainment. Biotechnol Bioeng 36:476-483.
12. Macintyre F. 1972. Flow patterns in breaking bubbles. J Geophys Res 77: 5211-5228.
13. McDowell CL, Papoutsakis ET. 1998. Increased agitation intensity increases CD13 receptor surface content and mRNA levels, and alters the metabolism of HL60 cells cultured in stirred tank bioreactors. Biotechnol Bioeng 60:239-250.
14. McDowell CL, Carver RT, Papoutsakis ET. 1998. Effects of Methocel A15LV, polyethylene glycol, and polyvinyl alcohol on CD13 and CD33 receptor surface content and metabolism of HL60 cells cultured in stirred tank bioreactors. Biotechnol Bioeng 60:251 -258.
15. Michaels JD, Petersen JF, McIntire LV, Papoutsakis ET. 1991. Protection mechanisms of freely suspended animal-cells (Crl 8018) from fluid- mechanical injury-Viscometric and bioreactor studies using serum, Pluronic F68 and polyethyleneglycol. Biotechnol Bioeng 38:169-180.
16. Michaels JD, Nowak JE, Mallik AK, Koczo K, Wasan DT, Papoutsakis ET. 1995a. Interfacial properties of cell-culture media with cell-protecting additives. Biotechnol Bioeng 47:420-430.
17. Michaels JD, Nowak JE, Mallik AK, Koczo K, Wasan DT, Papoutsakis ET. 1995b. Analysis of cell-to-bubble attachment in sparged bioreactors in the presence of cell-protecting additives. Biotechnol Bioeng 47:407-419.
18. Michaels JD, Mallik AK, Papoutsakis ET. 1996. Sparging and agitation- induced injury of cultured animal cells: Do cell-to-bubble interactions in the bulk liquid injure cells? Biotechnol Bioeng 51:399-409.
19. Papoutsakis ET. 1991a. Fluid-mechanical damage of animal-cells in bioreactors. Trends Biotechnol 9:427-437.
20. Papoutsakis ET. 1991. Media additives for protecting freely suspended animal-cells against agitation and aeration damage. Trends Biotechnol 9:316-324.
21. Tolbert WR, Hitt MM, Feder J. 1980. Cell aggregate suspension-culture for large-scale production of biomolecules. In Vitro J Tissue Culture Assoc 16:486-490.
22. Tolbert WR, Schoenfeld RA, Lewis C, Feder J. 1982. Large-scale mammalian-cell culture-Design and use of an economical batch suspension system. Biotechnol Bioeng 24:1671 -1679.