Genetic variation in SIPA1 in relation to breast cancer risk and survival after breast cancer diagnosis

International Journal of Cancer

Volumn 124, Issue 7, 2009, Pages 1716-1720

  Gaudet, Mia M ^a,e   Hunter, Kent ^a   Pharoah, Paul ^b   Dunning, Alison M ^b   Driver, Kristy ^b   Lissowska, Jolanta ^a,c   Sherman, Mark ^a   Peplonska, Beata ^d   Brinton, Louise A ^a   Chanock, Stephen ^a   Garcia Closas, Montserrat ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c INSTITUTE OF ONCOLOGY   (Poland)

^d NOFER INSTITUTE OF OCCUPATIONAL MEDICINE   (Poland)

^e MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ALLELE; ARTICLE; BREAST CANCER; CANCER MORTALITY; CANCER RISK; CANCER SURVIVAL; CASE CONTROL STUDY; CONTROL GROUP; CONTROLLED STUDY; DISEASE SEVERITY; EXON; FEMALE; FOLLOW UP; GENE; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; METASTASIS; OVERALL SURVIVAL; POLAND; PRIORITY JOURNAL; PROGNOSIS; SIGNAL INDUCED PROLIFERATION ASSOCIATED GENE 1; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR CLASSIFICATION; TUMOR LOCALIZATION; TUMOR VOLUME; UNITED KINGDOM; VITAL STATISTICS; BREAST TUMOR; GENETIC PREDISPOSITION; GENETICS; KAPLAN MEIER METHOD; MIDDLE AGED; MORTALITY; RISK FACTOR;

GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; NUCLEAR PROTEIN; SIPA1 PROTEIN, HUMAN;

ADULT; AGED; BREAST NEOPLASMS; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GTPASE-ACTIVATING PROTEINS; HUMANS; KAPLAN-MEIERS ESTIMATE; MIDDLE AGED; NUCLEAR PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; RISK FACTORS;

EID: 61449175948     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.23919     Document Type: Article

References (17)

1. Threadgill DW. Metastatic potential as a heritable trait. Nat Genet 2005;37:1026-7.
2. Weigelt B, Peterse JL, van 't Veer LJ. Breast cancer metastasis: markers and models. Nat Rev Cancer 2005;5:591-602.
3. Hunter KW, Broman KW, Voyer TL, Lukes L, Cozma D, Debies MT, Rouse J, Welch DR. Predisposition to efficient mammary tumor meta- static progression is linked to the breast cancer metastasis suppressor gene Brmsl. Cancer Res 2001;61:8866-72.
4. Park YG, Zhao X, Lesueur F, Lowy DR, Lancaster M, Pharoah P, Qian X, Hunter KW. Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1. Nat Genet 2005;37:1055-62.
5. Kurachi H, Wada Y, Tsukamoto N, Maeda M, Kubota H, Hattori M, Iwai K, Minato N. Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product. J Biol Chem 1997;272:28081-8.
6. Tsukamoto N, Hattori M, Yang H, Bos JL, Minato N. Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion. J Biol Chem 1999;274:18463-9.
7. Packer BR, Yeager M, Burdett L, Welch R, Beerman M, Qi L, Sicotte, Staats B, Acharya M, Crenshaw A, Eckert A, Puri V, et al. SNP500Cancer: a public resource for sequence validation, assay development, and frequency analysis for genetic variation in candidate genes. Nucleic Acids Res 2006;34:D617-21.
8. Crawford NP, Ziogas A, Peel DJ, Hess J, Anton-Culver H, Hunter KW. Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer. Breast Cancer Res 2006;8:R16.
9. Page DL. Prognosis and breast cancer. Recognition of lethal and favorable prognostic types. Am J Surg Pathol 1991;15:334-49.
10. Platet N, Cathiard AM, Gleizes M, Garcia M. Estrogens and their receptors in breast cancer progression: a dual role in cancer proliferation and invasion. Crit Rev Oncol Hematol 2004;51:55-67.
11. Garcia-Closas M, Brinton LA, Lissowska J, Chatterjee N, Peplonska B, Anderson WF, Szeszenia-Dabrowska N, Bardin-Mikolajczak A, Zatonski W, Blair A, Kalaylioglu Z, Rymkiewicz G, et al. Established breast cancer risk factors by clinically important tumour characteristics. Br J Cancer 2006;95:123-9.
12. Cebrian A, Pharoah PD, Ahmed S, Smith PL, Luccarini C, Luben R, Redman K, Munday H, Easton DF, Dunning AM, Ponder BA. Tagging single-nucleotide polymorphisms in antioxidant defense enzymes and susceptibility to breast cancer. Cancer Res 2006;66:1225-33.
13. Laird NM, Mosteller F. Some statistical methods for combining experimental results. Int J Technol Assess Health Care 1990;6:5-30.
14. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-81.
15. Cox DR. Regression models and life-tables (with discussion). J R Stat Soc Ser C Appl Stat 1972;Series B34:187-220.
16. Schoenfeld D. Partial residuals for the proportional hazards regression odel. Biometrika 1982;69:239-41.
17. Hunter DJ, Kraft P, Jacobs KB, Cox DG, Yeager M, Hankinson SE, Wacholder S, Wang Z, Welch R, Hutchinson A, Wang J, Yu K, et al. A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet 2007;39:870-4.