Vascular endothelial growth factor-C and -D expression correlates with lymph node micrometastasis in pN0 early gastric cancer

Journal of Surgical Oncology

Volumn 99, Issue 3, 2009, Pages 148-153

  Arigami, Takaaki ^a   Natsugoe, Shoji ^a   Uenosono, Yoshikazu ^a   Yanagita, Shigehiro ^a   Ehi, Katsuhiko ^a   Arima, Hideo ^a   Mataki, Yuko ^a   Nakajo, Akihiro ^a   Ishigami, Sumiya ^a   Aikou, Takashi ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

Gastric cancer; Lymph node micrometastasis; Reverse transcription polymerase chain reaction; Vascular endothelial growth factor (VEGF) C; VEGF D

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; EOSIN; HEMATOXYLIN; MESSENGER RNA; POLYCLONAL ANTIBODY; VASCULOTROPIN C; VASCULOTROPIN D; TUMOR MARKER; VEGFC PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CANCER INCIDENCE; CONTROLLED STUDY; EARLY CANCER; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MICROMETASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CANCER; ADENOCARCINOMA; CANCER INVASION; CANCER STAGING; COMPARATIVE STUDY; ENZYME IMMUNOASSAY; GENETICS; LYMPH NODE; METABOLISM; METASTASIS; MIDDLE AGED; PATHOLOGY; PROGNOSIS; STOMACH TUMOR; TUMOR CELL LINE;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CARCINOEMBRYONIC ANTIGEN; CELL LINE, TUMOR; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL; VASCULAR ENDOTHELIAL GROWTH FACTOR C; VASCULAR ENDOTHELIAL GROWTH FACTOR D;

EID: 61449148623     PISSN: 00224790     EISSN: 10969098     Source Type: Journal    
DOI: 10.1002/jso.21228     Document Type: Article

References (33)

1. Matsushita M, Hajiro K, Suzaki T, et al.: Histopathological assessment of lymph node metastasis in patients with gastric cancer. Hepatogastroenterology 1995;42:861-866.
2. Kwon SJ, Kim GS: Prognostic significance of lymph node metastasis in advanced carcinoma of the stomach. Br J Surg 1996;83:1600-1603.
3. Takagane A, Terashima M, Abe K, et al.: Evaluation of the ratio of lymph node metastasis as a prognostic factor in patients with gastric cancer. Gastric Cancer 1999;2:122-128.
4. Kunisaki C, Shimada H, Takahashi M, et al.: Prognostic factors in early gastric cancer. Hepatogastroenterology 2001;48:294-298.
5. Nitti D, Marchet A, Olivieri M, et al.: Ratio between metastatic and examined lymph nodes is an independent prognostic factor after D2 resection for gastric cancer: Analysis of a large European monoinstitutional experience. Ann Surg Oncol 2003;10:1077-1085.
6. Maehara Y, Okuyama T, Moriguchi S, et al.: Prophylactic lymph node dissection in patients with advanced gastric cancer promotes increased survival time. Cancer 1992;15:392-395.
7. Maehara Y, Orita H, Okuyama T, et al.: Predictors of lymph node metastasis in early gastric cancer. Br J Surg 1992;79:245-247.
8. Cai J, Ikeguchi M, Maeta M, et al.: Micrometastasis in lymph nodes and microinvasion of the muscularis propria in primary lesions of submucosal gastric cancer. Surgery 2000;127:32-39.
9. Kim DY, Joo JK, Ryu SY, et al.: Factors related to lymph node metastasis and surgical strategy used to treat early gastric carcinoma. World J Gastroenterol 2004;10:737-740.
10. Takekoshi T, Baba Y, Ota H, et al.: Endoscopic resection of early gastric carcinoma: Results of a retrospective analysis of 308 cases. Endoscopy 1994;26:352-358.
11. Yamao T, Shirao K, Ono H, et al.: Risk factors for lymph node metastasis from intramucosal gastric carcinoma. Cancer 1996;77:602-606.
12. Tsujitani S, Oka S, Saito H, et al.: Less invasive surgery for early gastric cancer based on the low probability of lymph node metastasis. Surgery 1999;125:148-154.
13. Folli S, Morgagni P, Roviello F, et al.: Risk factors for lymph node metastases and their prognostic significance in early gastric cancer (EGC) for the Italian Research Group for Gastric Cancer (IRGGC). Jpn J Clin Oncol 2001;31:495-499.
14. Mori M, Mimori K, Inoue H, et al.: Detection of cancer micrometastases in lymph nodes by reverse transcriptasepolymerase chain reaction. Cancer Res 1995;55:3417-3420.
15. Matsumoto M, Natsugoe S, Ishigami S, et al.: Lymph node micrometastasis and lymphatic mapping determined by reverse transcriptase-polymerase chain reaction in pN0 gastric carcinoma. Surgery 2002;131:630-635.
16. Siewert JR, Kestlmeier R, Busch R, et al.: Benefits of D2 lymph node dissection for patients with gastric cancer and pN0 and pN1 lymph node metastases. Br J Surg 1996;83:1144-1147.
17. Maehara Y, Oshiro T, Endo K, et al.: Clinical significance of occult micrometastasis lymph nodes from patients with early gastric cancer who died of recurrence. Surgery 1996;119:397-402.
18. Ishida K, Katsuyama T, Sugiyama A, et al.: Immunohistochemical evaluation of lymph node micrometastases from gastric carcinomas. Cancer 1997;79:1069-1076.
19. Breiteneder-Geleff S, Soleiman A, Kowalski H, et al.: Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: Podoplanin as a specific marker for lymphatic endothelium. Am J Pathol 1999;154:385-394.
20. Banerji S, Ni J, Wang SX, et al.: LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. J Cell Biol 1999;144:789-801.
21. Wigle JT, Oliver G: Prox1 function is required for the development of the murine lymphatic system. Cell 1999;98:769-778.
22. Joukov V, Pajusola K, Kaipainen A, et al.: A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J 1996;15:290-298.
23. Jeltsch M, Kaipainen A, Joukov V, et al.: Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. Science (Washington, DC) 1997;276:1423-1425.
24. Achen MG, Jeltsch M, Kukk E, et al.: Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). Proc Natl Acad Sci USA 1998;95:548-553.
25. Yonemura Y, Endo Y, Fujita H, et al.: Role of vascular endothelial growth factor C expression in the development of lymph node metastasis in gastric cancer. Clin Cancer Res 1999;5:1823-1829.
26. Kabashima A, Maehara Y, Kakeji Y, et al.: Overexpression of vascular endothelial growth factor C is related to lymphogenous metastasis in early gastric carcinoma. Oncology 2001;60:146-150.
27. Amioka T, Kitadai Y, Tanaka S, et al.: Vascular endothelial growth factor-C expression predicts lymph node metastasis of human gastric carcinomas invading the submucosa. Eur J Cancer 2002;38:1413-1419.
28. Ishikawa M, Kitayama J, Kazama S, et al.: Expression of vascular endothelial growth factor C and D (VEGF-C and -D) is an important risk factor for lymphatic metastasis in undifferentiated early gastric carcinoma. Jpn J Clin Oncol 2003;33:21-27.
29. Kawakami M, Furuhata T, Kimura Y, et al.: Quantification of vascular endothelial growth factor-C and its receptor-3 messenger RNA with real-time quantitative polymerase chain reaction as a predictor of lymph node metastasis in human colorectal cancer. Surgery 2003;133:300-308.
30. Onogawa S, Kitadai Y, Tanaka S, et al.: Expression of VEGF-C and VEGF-D at the invasive edge correlates with lymph node metastasis and prognosis of patients with colorectal carcinoma. Cancer Sci 2004;95:32-39.
31. Japanese Gastric Cancer Association: Japanese Classification of Gastric Carcinoma, 2nd English Edition. Gastric Cancer 1998;1:10-24.
32. Hsu SM, Raine L, Fanger H: Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 1981;29:577-580.
33. Gerhard M, Juhl H, Kalthoff H, et al.: Specific detection of carcinoembryonic antigen-expressing tumor cells in bone marrow aspirates by polymerase chain reaction. J Clin Oncol 1994;12:725-729.