Identification of a process impurity formed during synthesis of a nevirapine analogue HIV NNRT inhibitor using LC/MS and forced degradation studies

Journal of Pharmaceutical and Biomedical Analysis

Volumn 49, Issue 3, 2009, Pages 733-738

  Qiu, Fenghe ^a   Pennino, Scott ^a   Busacca, Carl A ^a   Norwood, Daniel L ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

Forced degradation; LC MS; Mechanism of formation; Oxidative degradation; Process impurity

Indexed keywords

NEVIRAPINE;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; DRUG IMPURITY; DRUG STRUCTURE; DRUG SYNTHESIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; OXIDATIVE STRESS; PHOTOOXIDATION; PRIORITY JOURNAL;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CONTAMINATION; LIGHT; MASS SPECTROMETRY; NEVIRAPINE; OXIDANTS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHOTOCHEMISTRY; REVERSE TRANSCRIPTASE INHIBITORS; SOLUTIONS; SOLVENTS;

EID: 61449121943     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.01.010     Document Type: Article

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