Influence of the solid form of siramesine hydrochloride on its behavior in aqueous environments

Pharmaceutical Research

Volumn 26, Issue 4, 2009, Pages 846-854

  Zimmermann, Anne ^a,c   Tian, Fang ^a   De Diego, Heidi Lopez ^b   Ringkjøbing Elema, Michiel ^b   Rantanen, Jukka ^a   Müllertz, Anette ^a   Hovgaard, Lars ^a,d  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b H LUNDBECK A S   (Denmark)

^c NEUROSEARCH A S   (Denmark)

^d NOVO NORDISK A S   (Denmark)

Author keywords

Dissolution rate; Monohydrate; Solution mediated transformation; Supersaturation; Wet massing

Indexed keywords

ALCOHOL; SIGMA RECEPTOR LIGAND; SIRAMESINE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DRUG SOLUBILITY; MICROSCOPY; PH MEASUREMENT; PRECIPITATION; PRIORITY JOURNAL; SOLID STATE; X RAY POWDER DIFFRACTION;

CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DOSAGE FORMS; ETHANOL; HYDROGEN-ION CONCENTRATION; INDOLES; KINETICS; MICROSCOPY; PHASE TRANSITION; POWDER DIFFRACTION; SOLUBILITY; SOLVENTS; SPECTRUM ANALYSIS, RAMAN; SPIRO COMPOUNDS; TECHNOLOGY, PHARMACEUTICAL; WATER;

EID: 61449120999     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-008-9783-0     Document Type: Article

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