Growth inhibition of hepatocellular carcinoma cells in vitro and in vivo by the 8-methoxy analog of WMC79

Cancer Chemotherapy and Pharmacology

Volumn 63, Issue 5, 2009, Pages 769-778

  Kosakowska Cholody, Teresa ^a   Cholody, Wieslaw M ^a   Hariprakasha, Humcha K ^a   Monks, Anne ^a   Kar, Siddhartha ^b   Wang, Meifang ^c   Michejda, Christopher J ^a   Carr, Brian I ^c  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Anti cancer activity; Cdc6; Cdc7; Hepatocellular carcinoma; Replication arrest

Indexed keywords

5 NITRO 2 [3 [4 [3 (6 OXO 6H 2,10B DIAZAACEANTHRYLEN 5 YLAMINO)PROPYL]PIPERAZIN 1 YL]PROPYL] 2 AZAPHENALENE 1,3 DIONE; 5 NITRO 2 [3 [4 [3 (8 METHOXY 6 OXO 6H 2,10B DIAZAACEANTHRYLEN 5 YLAMINO)PROPYL]PIPERAZIN 1 YL]PROPYL] 2 AZAPHENALENE 1,3 DIONE; ANTINEOPLASTIC AGENT; CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 6; CELL CYCLE PROTEIN 7; CYCLIN A; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; HKH 40 A; NSC 695942; PIPERAZINE DERIVATIVE; PROTEIN P21; PROTEIN P53; RTA 502; UNCLASSIFIED DRUG; WMC 79;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL STRAIN HEPG2; CLONOGENESIS; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG POTENCY; DRUG SAFETY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; UPREGULATION;

ACRIDONES; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; HUMANS; LIVER NEOPLASMS, EXPERIMENTAL; MOLECULAR STRUCTURE; NAPHTHALIMIDES; RATS; RATS, INBRED F344; S PHASE; TUMOR CELLS, CULTURED; TUMOR STEM CELL ASSAY; TUMOR SUPPRESSOR PROTEIN P53;

EID: 61449099538     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-008-0801-z     Document Type: Article

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