-
1
-
-
0023734130
-
Transfer of a functional human immune system to mice with severe combined immunodeficiency
-
Mosier DE, Gulizia RJ, Baird SM, Wilson DB: Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature 1988, 335:256-259.
-
(1988)
Nature
, vol.335
, pp. 256-259
-
-
Mosier, D.E.1
Gulizia, R.J.2
Baird, S.M.3
Wilson, D.B.4
-
2
-
-
7644226722
-
Murine T cells potently restrict human immunodeficiency virus infection
-
Baumann JG, Unutmaz D, Miller MD, et al.: Murine T cells potently restrict human immunodeficiency virus infection. J Virol 2004, 78:12537-12547.
-
(2004)
J Virol
, vol.78
, pp. 12537-12547
-
-
Baumann, J.G.1
Unutmaz, D.2
Miller, M.D.3
-
3
-
-
0025765862
-
The SCID-hu mouse: A small animal model for HIV infection and pathogenesis
-
McCune J, Kaneshima H, Krowka J, et al.: The SCID-hu mouse: a small animal model for HIV infection and pathogenesis. Annu Rev Immunol 1991, 9:399-429.
-
(1991)
Annu Rev Immunol
, vol.9
, pp. 399-429
-
-
McCune, J.1
Kaneshima, H.2
Krowka, J.3
-
5
-
-
33645924682
-
HIV disease: Fallout from a mucosal catastrophe?
-
Brenchley JM, Price DA, Douek DC: HIV disease: fallout from a mucosal catastrophe? Nat Immunol 2006, 7:235-239.
-
(2006)
Nat Immunol
, vol.7
, pp. 235-239
-
-
Brenchley, J.M.1
Price, D.A.2
Douek, D.C.3
-
6
-
-
34147108762
-
Pathogenesis of HIV in the gastrointestinal tract
-
Dandekar S: Pathogenesis of HIV in the gastrointestinal tract. Curr HIV/AIDS Rep 2007, 4:10-15.
-
(2007)
Curr HIV/AIDS Rep
, vol.4
, pp. 10-15
-
-
Dandekar, S.1
-
8
-
-
0031026261
-
Limits of the human-PBL-SCID mice model: Severe restriction of the V beta T-cell repertoire of engrafted human T cells
-
Garcia S, Dadaglio G, Gougeon ML: Limits of the human-PBL-SCID mice model: severe restriction of the V beta T-cell repertoire of engrafted human T cells. Blood 1997, 89:329-336.
-
(1997)
Blood
, vol.89
, pp. 329-336
-
-
Garcia, S.1
Dadaglio, G.2
Gougeon, M.L.3
-
9
-
-
0026082987
-
Limited B cell repertoire in severe combined immunodeficient mice engrafted with peripheral blood mononuclear cells derived from immunodeficient or normal humans
-
Saxon A, Macy E, Denis K, et al.: Limited B cell repertoire in severe combined immunodeficient mice engrafted with peripheral blood mononuclear cells derived from immunodeficient or normal humans. J Clin Invest 1991, 87:658-665.
-
(1991)
J Clin Invest
, vol.87
, pp. 658-665
-
-
Saxon, A.1
Macy, E.2
Denis, K.3
-
10
-
-
0023753744
-
The SCID-hu mouse: Murine model for the analysis of human hematolymphoid differentiation and function
-
McCune JM, Namikawa R, Kaneshima H, et al.: The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science 1988, 241:1632-1639.
-
(1988)
Science
, vol.241
, pp. 1632-1639
-
-
McCune, J.M.1
Namikawa, R.2
Kaneshima, H.3
-
11
-
-
34247120692
-
Limitations of the human-PBL-SCID mouse model for vaginal transmission of HIV-1
-
D'Cruz OJ, Uckun FM: Limitations of the human-PBL-SCID mouse model for vaginal transmission of HIV-1. Am J Reprod Immunol 2007, 57:353-360.
-
(2007)
Am J Reprod Immunol
, vol.57
, pp. 353-360
-
-
D'Cruz, O.J.1
Uckun, F.M.2
-
12
-
-
0042128299
-
Inhibition of vaginal transmission of HIV-1 in hu-SCID mice by the non-nucleoside reverse transcriptase inhibitor TMC120 in a gel formulation
-
Di Fabio S, Van Roey J, Giannini G, et al.: Inhibition of vaginal transmission of HIV-1 in hu-SCID mice by the non-nucleoside reverse transcriptase inhibitor TMC120 in a gel formulation. AIDS 2003, 17:1597-1604.
-
(2003)
AIDS
, vol.17
, pp. 1597-1604
-
-
Di Fabio, S.1
Van Roey, J.2
Giannini, G.3
-
13
-
-
0036150902
-
Vaginal transmission of cell-associated HIV-1 in the mouse is blocked by a topical, membrane-modifying agent
-
Khanna KV, Whaley KJ, Zeitlin L, et al.: Vaginal transmission of cell-associated HIV-1 in the mouse is blocked by a topical, membrane-modifying agent. J Clin Invest 2002, 109:205-211.
-
(2002)
J Clin Invest
, vol.109
, pp. 205-211
-
-
Khanna, K.V.1
Whaley, K.J.2
Zeitlin, L.3
-
14
-
-
33646342770
-
Microbicides and other topical strategies to prevent vaginal transmission of HIV
-
Lederman MM, Offord RE, Hartley O: Microbicides and other topical strategies to prevent vaginal transmission of HIV. Nat Rev Immunol 2006, 6:371-382.
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 371-382
-
-
Lederman, M.M.1
Offord, R.E.2
Hartley, O.3
-
15
-
-
0028970284
-
HIV-1-induced thymocyte depletion is associated with indirect cytopathogenicity and infection of progenitor cells in vivo
-
Su L, Kaneshima H, Bonyhadi M, et al.: HIV-1-induced thymocyte depletion is associated with indirect cytopathogenicity and infection of progenitor cells in vivo. Immunity 1995, 2:25-36.
-
(1995)
Immunity
, vol.2
, pp. 25-36
-
-
Su, L.1
Kaneshima, H.2
Bonyhadi, M.3
-
16
-
-
57749120819
-
Validation of the SCID-hu thy/liv mouse model with four classes of licensed antiretrovirals
-
Stoddart CA, Bales CA, Bare JC, et al.: Validation of the SCID-hu thy/liv mouse model with four classes of licensed antiretrovirals. PLoS ONE 2007, 2: e655.
-
(2007)
PLoS ONE
, vol.2
-
-
Stoddart, C.A.1
Bales, C.A.2
Bare, J.C.3
-
17
-
-
1842588698
-
Development of a human adaptive immune system in cord blood cell-transplanted mice
-
Traggiai E, Chicha L, Mazzucchelli L, et al.: Development of a human adaptive immune system in cord blood cell-transplanted mice. Science 2004, 304:104-107.
-
(2004)
Science
, vol.304
, pp. 104-107
-
-
Traggiai, E.1
Chicha, L.2
Mazzucchelli, L.3
-
18
-
-
34248547056
-
Human-hemato-lymphoid-system mice: Opportunities and challenges
-
Manz MG: Human-hemato-lymphoid-system mice: opportunities and challenges. Immunity 2007, 26:537-541.
-
(2007)
Immunity
, vol.26
, pp. 537-541
-
-
Manz, M.G.1
-
19
-
-
33751003823
-
HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-gamma c-/- (RAG-hu) mouse model
-
Berges BK, Wheat WH, Palmer BE, et al.: HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-gamma c-/- (RAG-hu) mouse model. Retrovirology 2006, 3:76.
-
(2006)
Retrovirology
, vol.3
, pp. 76
-
-
Berges, B.K.1
Wheat, W.H.2
Palmer, B.E.3
-
20
-
-
58149467209
-
Evaluation of safety and efficacy of RNAi against HIV-1 in the human immune system (Rag-2(-/-)(c)(-/-)) mouse model
-
Jul 31 Epub ahead of print
-
Ter Brake O, Legrand N, von Eije KJ, et al.: Evaluation of safety and efficacy of RNAi against HIV-1 in the human immune system (Rag-2(-/-)(c)(-/-)) mouse model. Gene Ther 2008 Jul 31 (Epub ahead of print).
-
(2008)
Gene Ther
-
-
Ter Brake, O.1
Legrand, N.2
von Eije, K.J.3
-
21
-
-
44649186124
-
Effect of transcription peptide inhibitors on HIV-1 replication
-
Van Duyne R, Cardenas J, Easley R, et al.: Effect of transcription peptide inhibitors on HIV-1 replication. Virology 2008, 376:308-322.
-
(2008)
Virology
, vol.376
, pp. 308-322
-
-
Van Duyne, R.1
Cardenas, J.2
Easley, R.3
-
22
-
-
34248335883
-
Use of a novel chimeric mouse model with a functionally active human immune system to study human immunodeficiency virus type 1 infection
-
An DS, Poon B, Ho Tsong, et al.: Use of a novel chimeric mouse model with a functionally active human immune system to study human immunodeficiency virus type 1 infection. Clin Vaccine Immunol 2007, 14:391-396.
-
(2007)
Clin Vaccine Immunol
, vol.14
, pp. 391-396
-
-
An, D.S.1
Poon, B.2
Ho, T.3
-
23
-
-
33750436225
-
-
-/- mice.
-
-/- mice.
-
-
-
-
24
-
-
40849104785
-
-
-/- mice.
-
-/- mice.
-
-
-
-
25
-
-
33947356676
-
Human immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/-gammac-/- mice
-
Gorantla S, Sneller H, Walters L, et al.: Human immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/-gammac-/- mice. J Virol 2007, 81:2700-2712.
-
(2007)
J Virol
, vol.81
, pp. 2700-2712
-
-
Gorantla, S.1
Sneller, H.2
Walters, L.3
-
26
-
-
53449092578
-
-
-/- mice.
-
-/- mice.
-
-
-
-
27
-
-
33947596455
-
HIV-1 infection and pathogenesis in a novel humanized mouse model
-
Zhang L, Kovalev GI, Su L: HIV-1 infection and pathogenesis in a novel humanized mouse model. Blood 2007, 109:2978-2981.
-
(2007)
Blood
, vol.109
, pp. 2978-2981
-
-
Zhang, L.1
Kovalev, G.I.2
Su, L.3
-
28
-
-
0042243661
-
Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammcnull mice model
-
Hiramatsu H, Nishikomori R, Heike T, et al.: Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammcnull mice model. Blood 2003, 102:873-880.
-
(2003)
Blood
, vol.102
, pp. 873-880
-
-
Hiramatsu, H.1
Nishikomori, R.2
Heike, T.3
-
29
-
-
23744474685
-
Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice
-
Ishikawa F, Yasukawa M, Lyons B, et al.: Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice. Blood 2005, 106:1565-1573.
-
(2005)
Blood
, vol.106
, pp. 1565-1573
-
-
Ishikawa, F.1
Yasukawa, M.2
Lyons, B.3
-
30
-
-
36349028152
-
Humanized NOD/SCID/IL2R {gamma}null mice transplanted with hematopoietic stem cells under nonmyeloablative conditions show prolonged life spans and allow detailed analysis of human immunodeficiency virus type 1 pathogenesis
-
Watanabe S, Ohta S, Yajima M, et al.: Humanized NOD/SCID/IL2R {gamma}null mice transplanted with hematopoietic stem cells under nonmyeloablative conditions show prolonged life spans and allow detailed analysis of human immunodeficiency virus type 1 pathogenesis. J Virol 2007, 81:13259-13264.
-
(2007)
J Virol
, vol.81
, pp. 13259-13264
-
-
Watanabe, S.1
Ohta, S.2
Yajima, M.3
-
31
-
-
33846104485
-
-
-/- mice.
-
-/- mice.
-
-
-
-
32
-
-
49549117077
-
T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice
-
Kumar P, Ban HS, Kim SS, et al.: T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell 2008, 134:577-586.
-
(2008)
Cell
, vol.134
, pp. 577-586
-
-
Kumar, P.1
Ban, H.S.2
Kim, S.S.3
-
33
-
-
33750705617
-
-
•• Melkus MW, Estes JD, Padgett-Thomas A, et al.: Humanized mice mount specific adaptive and innate immune response to EBV and TSST-1. Nat Med 2006, 12:1316-1322. This article describes in detail the development of humanized BLT mice demonstrating the bona fide development of functional human T cells in the context of a human thymic microenvironment.
-
•• Melkus MW, Estes JD, Padgett-Thomas A, et al.: Humanized mice mount specific adaptive and innate immune response to EBV and TSST-1. Nat Med 2006, 12:1316-1322. This article describes in detail the development of humanized BLT mice demonstrating the bona fide development of functional human T cells in the context of a human thymic microenvironment.
-
-
-
-
34
-
-
44449141907
-
Functional and phenotypic characterization of the humanized BLT mouse model
-
Wege AK, Melkus MW, Denton PW, et al.: Functional and phenotypic characterization of the humanized BLT mouse model. Curr Top Microbiol Immunol 2008, 324:149-165.
-
(2008)
Curr Top Microbiol Immunol
, vol.324
, pp. 149-165
-
-
Wege, A.K.1
Melkus, M.W.2
Denton, P.W.3
-
35
-
-
43249106514
-
-
•• Tonomura N, Habiro K, Shimizu A, et al.: Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model. Blood 2008, 111:4293-4296. This paper presents evidence of antigen-specific human B-cell responses and T-cell-dependent production of human antibodies in BLT mice.
-
•• Tonomura N, Habiro K, Shimizu A, et al.: Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model. Blood 2008, 111:4293-4296. This paper presents evidence of antigen-specific human B-cell responses and T-cell-dependent production of human antibodies in BLT mice.
-
-
-
-
36
-
-
33745959565
-
Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation
-
Lan P, Tonomura N, Shimizu A, et al.: Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation. Blood 2006, 108:487-492.
-
(2006)
Blood
, vol.108
, pp. 487-492
-
-
Lan, P.1
Tonomura, N.2
Shimizu, A.3
-
37
-
-
42649142919
-
Pig islet xenograft rejection in a mouse model with an established human immune system
-
Tonomura N, Shimizu A, Wang S, et al.: Pig islet xenograft rejection in a mouse model with an established human immune system. Xenotransplantation 2008, 15:129-135.
-
(2008)
Xenotransplantation
, vol.15
, pp. 129-135
-
-
Tonomura, N.1
Shimizu, A.2
Wang, S.3
-
38
-
-
0030199031
-
Bacterial superantigens induce V beta-specific T cell receptor internalization
-
Makida R, Hofer MF, Takase K, et al.: Bacterial superantigens induce V beta-specific T cell receptor internalization. Mol Immunol 1996, 33:891-900.
-
(1996)
Mol Immunol
, vol.33
, pp. 891-900
-
-
Makida, R.1
Hofer, M.F.2
Takase, K.3
-
39
-
-
34247392343
-
-
•• Sun Z, Denton PW, Estes JD, et al.: Intrarectal transmission, systemic infection and CD4+ T cell depletion in humanized mice infected with HIV-1. J Exp Med 2007, 204:705-714. This paper presents the most extensive characterization of the specific human reconstitution of the GALT of BLT mice, the rectal transmission of HIV, and the extensive sequela caused by a highly pathogenic virus.
-
•• Sun Z, Denton PW, Estes JD, et al.: Intrarectal transmission, systemic infection and CD4+ T cell depletion in humanized mice infected with HIV-1. J Exp Med 2007, 204:705-714. This paper presents the most extensive characterization of the specific human reconstitution of the GALT of BLT mice, the rectal transmission of HIV, and the extensive sequela caused by a highly pathogenic virus.
-
-
-
-
40
-
-
4644342929
-
CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract
-
Brenchley JM, Schacker TW, Ruff LE, et al.: CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med 2004, 200:749-759.
-
(2004)
J Exp Med
, vol.200
, pp. 749-759
-
-
Brenchley, J.M.1
Schacker, T.W.2
Ruff, L.E.3
-
41
-
-
0035871634
-
Migration and maturation of human colonic dendritic cells
-
Bell SJ, Rigby R, English N, et al.: Migration and maturation of human colonic dendritic cells. J Immunol 2001, 166:4958-4967.
-
(2001)
J Immunol
, vol.166
, pp. 4958-4967
-
-
Bell, S.J.1
Rigby, R.2
English, N.3
-
42
-
-
0031593661
-
CD4+ CD8+ and CD8alpha+ beta- T lymphocytes in human small intestinal lamina propria
-
Abuzakouk M, Carton J, Feighery C, et al.: CD4+ CD8+ and CD8alpha+ beta- T lymphocytes in human small intestinal lamina propria. Eur J Gastroenterol Hepatol 1998, 10:325-329.
-
(1998)
Eur J Gastroenterol Hepatol
, vol.10
, pp. 325-329
-
-
Abuzakouk, M.1
Carton, J.2
Feighery, C.3
-
43
-
-
6944232241
-
CD4+CD8+ human small intestinal T cells are decreased in coeliac patients, with CD8 expression downregulated on intraepithelial T cells in the active disease
-
Carton J, Byrne B, Madrigal-Estebas L, et al.: CD4+CD8+ human small intestinal T cells are decreased in coeliac patients, with CD8 expression downregulated on intraepithelial T cells in the active disease. Eur J Gastroenterol Hepatol 2004, 16:961-968.
-
(2004)
Eur J Gastroenterol Hepatol
, vol.16
, pp. 961-968
-
-
Carton, J.1
Byrne, B.2
Madrigal-Estebas, L.3
-
44
-
-
0027454365
-
Flow cytometric analysis of intraepithelial lymphocytes from human small intestinal biopsies reveals populations of CD4+CD8+ and CD8[alpha][alpha]+ cells
-
Lynch S, Kelleher D, Feighery C, et al.: Flow cytometric analysis of intraepithelial lymphocytes from human small intestinal biopsies reveals populations of CD4+CD8+ and CD8[alpha][alpha]+ cells. Eur J Gastroenterol Hepatol 1993, 5:907-912.
-
(1993)
Eur J Gastroenterol Hepatol
, vol.5
, pp. 907-912
-
-
Lynch, S.1
Kelleher, D.2
Feighery, C.3
-
45
-
-
38849136442
-
-
•• Denton PW, Estes JD, Sun Z, et al.: Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice. PLoS Med 2008, 5: e16. This article characterized the human reconstitution of the female reproductive tract of BLT mice that facilitates vaginal HIV-1 transmission in BLT mice and demonstrated the protective effect of pre-exposure prophylaxis with antiretroviral drugs.
-
•• Denton PW, Estes JD, Sun Z, et al.: Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice. PLoS Med 2008, 5: e16. This article characterized the human reconstitution of the female reproductive tract of BLT mice that facilitates vaginal HIV-1 transmission in BLT mice and demonstrated the protective effect of pre-exposure prophylaxis with antiretroviral drugs.
-
-
-
-
46
-
-
34250347720
-
Role of Nef in HIV-1 replication and pathogenesis
-
Foster JL, Garcia JV: Role of Nef in HIV-1 replication and pathogenesis. Adv Pharmacol 2007, 55:389-409.
-
(2007)
Adv Pharmacol
, vol.55
, pp. 389-409
-
-
Foster, J.L.1
Garcia, J.V.2
-
47
-
-
33947417697
-
Understanding the failure of CD8+ T-cell vaccination against simian/human immunodeficiency virus
-
De Boer RJ: Understanding the failure of CD8+ T-cell vaccination against simian/human immunodeficiency virus. J Virol 2007, 81:2838-2848.
-
(2007)
J Virol
, vol.81
, pp. 2838-2848
-
-
De Boer, R.J.1
-
48
-
-
29244474887
-
HIV vaccine design: Insights from live attenuated SIV vaccines
-
Koff WC, Johnson PR, Watkins DI, et al.: HIV vaccine design: insights from live attenuated SIV vaccines. Nat Immunol 2006, 7:19-23.
-
(2006)
Nat Immunol
, vol.7
, pp. 19-23
-
-
Koff, W.C.1
Johnson, P.R.2
Watkins, D.I.3
-
49
-
-
0038638590
-
HIV vaccines 1983-2003
-
McMichael AJ, Hanke T: HIV vaccines 1983-2003. Nat Med 2003, 9:874-880.
-
(2003)
Nat Med
, vol.9
, pp. 874-880
-
-
McMichael, A.J.1
Hanke, T.2
-
50
-
-
57349129555
-
RAG2-/-gamma(c)-/- mice transplanted with CD34+ cells from human cord blood show low levels of intestinal engraftment and are resistant to rectal transmission of human immunodeficiency virus
-
Hofer U, Baenziger S, Heikenwalder M, et al.: RAG2-/-gamma(c)-/- mice transplanted with CD34+ cells from human cord blood show low levels of intestinal engraftment and are resistant to rectal transmission of human immunodeficiency virus. J Virol 2008, 82:12145-12153.
-
(2008)
J Virol
, vol.82
, pp. 12145-12153
-
-
Hofer, U.1
Baenziger, S.2
Heikenwalder, M.3
|