Stability evaluation and sensitive determination of antiviral drug, valacyclovir and its metabolite acyclovir in human plasma by a rapid liquid chromatography-tandem mass spectrometry method

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 8-9, 2009, Pages 680-688

  Yadav, Manish ^a,b   Upadhyay, Vivek ^a   Singhal, Puran ^a   Goswami, Sailendra ^a   Shrivastav, Pranav S ^b  

^a Veeda Clinical Research India   (India)

^b GUJARAT UNIVERSITY   (India)

Author keywords

Acyclovir; Bench top stability; High throughput; LC ESI MS MS; Solid phase extraction; Valacyclovir

Indexed keywords

CHROMATOGRAPHIC ANALYSIS; ELECTROSPRAY IONIZATION; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; METHANOL; ORGANIC ACIDS; PLASMA (HUMAN); PLASMAS; SPECTRUM ANALYSIS; THROUGHPUT;

ACYCLOVIR; BENCH TOP STABILITY; HIGH THROUGHPUT; LC-ESI-MS/MS; SOLID PHASE EXTRACTION; VALACYCLOVIR;

PLASMA STABILITY;

ACICLOVIR; ANTIVIRUS AGENT; DRUG METABOLITE; FLUCONAZOLE; FORMIC ACID; KETOCONAZOLE; METHANOL; MYCOPHENOLIC ACID; VALACICLOVIR;

ACCURACY; ADULT; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PLASMA; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SINGLE DRUG DOSE; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; VALIDITY;

ACYCLOVIR; ADULT; CHROMATOGRAPHY, LIQUID; HUMANS; MALE; MIDDLE AGED; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; VALINE; YOUNG ADULT;

EID: 61349201634     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.01.042     Document Type: Article

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