Caloric restriction does not offset age-associated changes in the biophysical properties of motoneurons

Journal of Neurophysiology

Volumn 101, Issue 2, 2009, Pages 548-557

  Kalmar, Jayne M ^a   Button, Duane C ^a   Gardiner, Kalan ^a   Cahill, Farrell ^a   Gardiner, Phillip F ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AFTERHYPERPOLARIZATION; AGING; ANIMAL EXPERIMENT; ARTICLE; BIOPHYSICS; CALORIC RESTRICTION; CONTROLLED STUDY; FEMALE; MOTONEURON; NONHUMAN; PRIORITY JOURNAL; RAT; SPIKE WAVE; STEADY STATE;

AGING; ANALYSIS OF VARIANCE; ANIMALS; BIOPHYSICAL PROCESSES; CALORIC RESTRICTION; CHI-SQUARE DISTRIBUTION; ELECTRIC CONDUCTIVITY; ELECTRIC STIMULATION; FEMALE; MEMBRANE POTENTIALS; MOTOR NEURONS; RATS; RATS, INBRED STRAINS; SPINAL CORD;

EID: 61349185119     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.90617.2008     Document Type: Article

References (49)

1. Adams MM, Shi L, Linville MC, Forbes ME, Long AB, Bennett C, Newton IG, Carter CS, Sonntag WE, Riddle DR, Brunso-Bechtold JK. Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning ability. Exp Neurol 1: 141-149, 2008.
2. Alshuaib WB, Hasan SM, Cherian SP, Mathew MV, Hasan MY, Fahim MA. Reduced potassium currents in old rat CA1 hippocampal neurons. J Neurosci Res 63: 176-184, 2001.
3. Bassey EJ, Harries UJ. Normal values for handgrip strength in 920 men and women aged over 65 years, and longitudinal changes over 4 years in 620 survivors. Clin Sci 84: 331-337, 1993.
4. Baudry S, Klass M, Pasquet B, Duchateau J. Age-related fatigability of the ankle dorsiflexor muscles during concentric and eccentric contractions. Eur J Appl Physiol 100: 515-525, 2007.
5. Beckman KB, Ames BN. The free radical theory of aging matures. Physiol Rev 78: 547-581, 1998.
6. Bennett DJ, Li Y, Siu M. Plateau potentials in sacrocaudal motoneurons of chronic spinal rats, recorded in vitro. J Neurophysiol 86: 1955-1971, 2001.
7. Butterfield DA, Howard BJ, LaFontaine MA. Brain oxidative stress in animal models of accelerated aging and the age-related neurodegenerative disorders, Alzheimer's disease and Huntington's disease. Curr Med Chem 8: 815-828, 2001.
8. Button DC, Gardiner K, Marqueste T, Gardiner PF. Frequency-current relationships of rat hindlimb alpha-motoneurons. J Physiol 573: 663-677, 2006.
9. Button DC, Kalmar JM, Gardiner K, Cahill F, Gardiner PF. Spike frequency adaptation of rat hindlimb motoneurons. J Appl Physiol 102: 1041-1050, 2007.
10. Button DC, Kalmar JM, Gardiner K, Marqueste T, Zhong H, Roy RR, Edgerton VR, Gardiner PF. Does elimination of afferent input modify the changes in rat motoneuron properties that occur following chronic spinal cord transection? J Physiol 586: 529-544, 2008.
11. Chung YH, Joo KM, Kim MJ, Cha CI. Age-related changes in the distribution of Na(v)1.1 and Na(v)1.2 in rat cerebellum. Neuroreport 14: 841-845, 2003.
12. Chung YH, Shin CM, Kim MJ, Lee BK, Cha CI. Age-related changes in the distribution of Kv1.1 and Kv1.2 channel subunits in the rat cerebellum. Brain Res 897: 193-198, 2001a.
13. Chung YH, Shin CM, Kim MJ, Shin DH, Yoo YB, Cha CI. Differential alterations in the distribution of voltage-gated calcium channels in aged rat cerebellum. Brain Res 903: 247-252, 2001b.
14. Colavitti R, Finkel T. Reactive oxygen species as mediators of cellular senescence. IUBMB Life 57: 277-281, 2005.
15. Cormery B, Beaumont E, Csukly K, Gardiner P. Hindlimb unweighting for 2 weeks alters physiological properties of rat hindlimb motoneurons. J Physiol 568: 841-850, 2005.
16. Cunningham DA, Morrison D, Rice CL, Cooke C. Aging and isokinetic plantar flexion. Eur J Appl Physiol Occup Physiol 56: 24-29, 1987.
17. Diao LH, Bickford PC, Stevens JO, Cline EJ, Gerhardt GA. Caloric restriction enhances evoked DA overflow in striatum and nucleus accumbens of aged Fischer 344 rats. Brain Res 763: 276-280, 1997.
18. Eckles-Smith K, Clayton D, Bickford P, Browning MD. Caloric restriction prevents age-related deficits in LTP and in NMDA receptor expression. Brain Res Mol Brain Res 78: 154-162, 2000.
19. Fontan-Lozano A, Saez-Cassanelli JL, Inda MC, los Santos-Arteaga M, Sierra-Dominguez SA, Lopez-Lluch G, Delgado-Garcia JM, Carrion AM. Caloric restriction increases learning consolidation and facilitates synaptic plasticity through mechanisms dependent on NR2B subunits of the NMDA receptor. J Neurosci 27: 10185-10195, 2007.
20. Gardiner P, Dai Y, Heckman CJ. Effects of exercise training on alpha-motoneurons. J Appl Physiol 101: 1228-1236, 2006.
21. Grimby G, Danneskiold-Samsoe B, Hvid K, Saltin B. Morphology and enzymatic capacity in arm and leg muscles in 78-81 year old men and women. Acta Physiol Scand 115: 125-134, 1982.
22. Harvey PJ, Li X, Li Y, Bennett DJ. 5-ht2 receptor activation facilitates a persistent sodium current and repetitive firing in spinal motoneurons of rats with and without chronic spinal cord injury. J Neurophysiol 96: 1158-1170, 2006a.
23. Harvey PJ, Li X, Li Y, Bennett DJ. Endogenous monoamine receptor activation is essential for enabling persistent sodium currents and repetitive firing in rat spinal motoneurons. J Neurophysiol 96: 1171-1186, 2006b.
24. Harvey PJ, Li Y, Li X, Bennett DJ. Persistent sodium currents and repetitive firing in motoneurons of the sacrocaudal spinal cord of adult rats. J Neurophysiol 96: 1141-1157, 2006c.
25. Heckmann CJ, Gorassini MA, Bennett DJ. Persistent inward currents in motoneuron dendrites: implications for motor output. Muscle Nerve 31: 135-156, 2005.
26. Hiona A, Leeuwenburgh C. Effects of age and caloric restriction on brain neuronal cell death/survival. Ann NY Acad Sci 1019: 96-105, 2004.
27. Jakobsson F, Borg K, Edstrom L, Grimby L. Use of motor units in relation to muscle fiber type and size in man. Muscle Nerve 11: 1211-1218, 1988.
28. Johnson H, Ulfhake B, Dagerlind A, Bennett GW, Fone KC, Hokfelt T. The serotoninergic bulbospinal system and brain stem-spinal cord content of serotonin-, TRH-, and substance P-like immunoreactivity in the aged rat with special reference to the spinal cord motor nucleus. Synapse 15: 63-89, 1993.
29. Kanda K. Effects of food restriction on motoneuronal loss with advancing age in the rat. Microsc Res Tech 59: 301-305, 2002.
30. Kanda K, Hashizume K. Changes in properties of the medial gastrocnemius motor units in aging rats. J Neurophysiol 61: 737-746, 1989.
31. Kanda K, Hashizume K, Nomoto E, Asaki S. The effects of aging on physiological properties of fast and slow twitch motor units in the rat gastrocnemius. Neurosci Res 3: 242-246, 1986.
32. Klein CS, Rice CL, Ivanova TD, Garland SJ. Changes in motor unit discharge rate are not associated with the amount of twitch potentiation in old men. J Appl Physiol 93: 1616-1621, 2002.
33. Larsson L. Histochemical characteristics of human skeletal muscle during aging. Acta Physiol Scand 117: 469-471, 1983.
34. Larsson L, Karlsson J. Isometric and dynamic endurance as a function of age and skeletal muscle characteristics. Acta Physiol Scand 104: 129-136, 1978.
35. Lee RH, Heckman CJ. Bistability in spinal motoneurons in vivo: systematic variations in rhythmic firing patterns. J Neurophysiol 80: 572-582, 1998.
36. Lexell J, Henriksson-Larsen K, Winblad B, Sjostrom M. Distribution of different fiber types in human skeletal muscles: effects of aging studied in whole muscle cross sections. Muscle Nerve 6: 588-595, 1983.
37. Lexell J, Taylor CC, Sjostrom M. What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men. J Neurol Sci 84: 275-294, 1988.
38. Li X, Murray K, Harvey PJ, Ballou EW, Bennett DJ. Serotonin facilitates a persistent calcium current in motoneurons of rats with and without chronic spinal cord injury. J Neurophysiol 97: 1236-1246, 2007.
39. Martin I, Grotewiel MS. Oxidative damage and age-related functional declines. Mechan Aging Dev 127: 411-423, 2006.
40. Morales FR, Boxer PA, Fung SJ, Chase MH. Basic electrophysiological properties of spinal cord motoneurons during old age in the cat. J Neurophysiol 58: 180-194, 1987.
41. Morrison JH, Hof PR. Life and death of neurons in the aging brain. Science 278: 412-419, 1997.
42. Okada M, Nakanishi H, Amamoto T, Urae R, Ando S, Yazawa K, Fujiwara M. How does prolonged caloric restriction ameliorate age-related impairment of long-term potentiation in the hippocampus? Mol Brain Res 111: 175-181, 2003.
43. Poulin MJ, Vandervoort AA, Paterson DH, Kramer JF, Cunningham DA. Eccentric and concentric torques of knee and elbow extension in young and older men. Can J Sport Sci 17: 3-7, 1992.
44. Ranson RN, Dodds AL, Smith MJ, Santer RM, Watson AH. Age-associated changes in the monoaminergic innervation of rat lumbosacral spinal cord. Brain Res 972: 149-158, 2003.
45. Turturro A, Witt WW, Lewis S, Hass BS, Lipman RD, Hart RW. Growth curves and survival characteristics of the animals used in the Biomarkers of Aging Program. J Gerontol A Biol Sci Med Sci 54: B492-B501, 1999.
46. Vandervoort AA, Kramer JF, Wharram ER. Eccentric knee strength of elderly females. J Gerontol 45: B125-B128, 1990.
47. Vandervoort AA, McComas AJ. Contractile changes in opposing muscles of the human ankle joint with aging. J Appl Physiol 61: 361-367, 1986.
48. Yoon T, De Lap BS, Griffith EE, Hunter SK. Age-related muscle fatigue after a low-force fatiguing contraction is explained by central fatigue. Muscle Nerve 37: 457-466, 2008.
49. Young A, Stokes M, Crowe M. The size and strength of the quadriceps muscles of old and young men. Clin Physiol 5: 145-154, 1985.